Anti-Inflammatory/Anti-Aging Strategies
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Author Archives: Dr. Hellen

During a recent 5-day cancer conference in Washington, D.C. additional evidence was presented about the fact that inflammation produced by fat cells (adipose tissue) contributes to the growth and spread of tumors.

Dr. M.Kolonin of the University of Texas Health Science Center in Texas has been quoted as saying: “Obesity is the leading preventable cause of cancer in the U.S. Extra body fat not only increases one’s risk of developing cancer, it is also associated with poorer prognosis [outcomes]”… “Ten percent to fifteen percent of cancer deaths may be attributed to obesity”.

Exactly how body fat influences cancer development is still under investigation, but the key appears to be the inflammatory responses of the body to cancer cells and vice versa. Macrophages are one of the major classes of white blood cells responsible for starting the inflammatory response when the body is threatened by cancer cells, and  reducing inflammation when the challenge is over.

Typically, the breast tissue of overweight and obese young women is more inflamed, and has more immune cells, such as macrophages compared to women of healthy weight.  Also cancer in obese women is more difficult to treat than in women at healthier weight.

Metabolic syndrome is associated with a group of factors that puts one at greater risk of having heart disease,diabetes and stroke. If a person has three of the following factors, or are on medication for them, it is called having a metabolic syndrome.  These factors are: excess stomach fat, high blood pressure and triglycerides. low levels of “good” cholesterol (HDL), and high blood sugar.

Image Fat cancer inflammation

In one study of 100 women, half of the women with inflammation of their breasts and early-stage breast cancer also had metabolic syndrome. 

Since obesity contributes to growth of tumors, investigators wondered whether weight loss might reverse the tendency to grow tumors.  In mice, tumors grew more slowly in obese mice that had previously lost weight.   

The body tightly regulates its inflammatory responses by balancing the amount of inflammatory and anti-inflammatory immune factors it produces. Fat cells naturally produce inflammatory molecules.  High amounts of body fat encourages growth of cancer cells.`

Note:

Controlling one’s weight at healthy levels, being physically active for 2.5 hours/week, getting outside every day for a few minutes and using a superior immune-balancing supplement will go a long ways toward helping the body stay in immune balance, stay in immune homeostasis,

Dr.Hellen is available to help you enhance your quality of life to its maximum.  She can be contacted by using this form, contacting her at: drhellen@drhellengreenblatt.info or feel free to call her at:  302.265.3870 (ET, USA).

 

https://meyercancer.weill.cornell.edu/how_obesity_fuels_cancer
www.the-scientist.com/?articles.view/articleNo/49051/title/Fat-s-Influence-on-Cancer/
www.springer.com/us/book/9781461468189
clincancerres.aacrjournals.org/content/early/2016/02/14/1078-0432.CCR-15-2239
www.nhlbi.nih.gov/health/health-topics/topics/ms
journal.frontiersin.org/article/10.3389/fonc.2014.00175/full
www.ncbi.nlm.nih.gov/pubmed/27617172
  

What is the Role of Inflammation?
When the body is injured or recognizes the presence of pathogens such as bacteria, viruses, molds, parasites or cancerous cells, its immune system is triggered to respond with inflammation to “burn” the threat out of the body.

Balance is Essential
Once the challenge has been met, a person in immune balance, homeostasis, will reduce the amount of inflammation that they are producing to “normal” levels. Uncontrolled, run-away  inflammation leads to autoimmune diseases (against oneself) in which its own tissues and organs are attacked.

Lupus
Systemic lupus erythematosus (SLE), lupus, is a complicated autoimmune condition affecting virtually every organ in the human body. Because of the wide-range of symptoms experienced, the disease is often difficult to diagnose. Common symptoms are extreme fatigue, swollen and/or painful joints, muscle pain, low-grade fever, thinning or loss of hair, butter-fly shaped rash across the nose and cheeks, chest pain when taking a deep breath, kidney and heart problems.

Butterfly rash

“Butterfly Rash” often associated with SLE
(
emedicine.medscape.com)

 

Females make up 80-90% of people with lupus and despite treatment, many individuals will experience flares and remissions (symptoms come and go) their entire lives.

Lupus and Inflammation
The hallmark of lupus is over-activity of the immune system and inflammation. Imbalances of inflammatory immune factors, cytokines, are significantly higher in lupus patients compared to people without lupus. These immune molecules promote inflammation and damage tissues.  High levels of these inflammatory factors are associated with the severity of disease but decrease as individuals are successfully treated.

Anti-malaria medications originally used to prevent or treat malaria has been used to treat lupus.It was not understood why these medicines were somewhat effective against SLE, but a recent study suggests that these medications inhibit inflammation.

Physical Activity
Every time a muscle contracts, it releases anti-inflammatory molecules that helps the body balance the amount of overall inflammation produced.

As would be predicted, weekly physical activity improves fatigue, depression and increases the quality of life of most individuals. Even moderate exercise, 3 days a week for 20 minutes, has been shown to make a major difference in the amount of energy and feelings of well-being experienced by lupus patients.

If  You Have Lupus
Frequent physical activity, eating in a healthful manner and daily consumption of an excellent immune balancing supplement helps the body control inflammation and achieve immune homeostasis (immune balance).

Dr.Hellen is passionate about helping people enjoy life at its fullest. She may be contacted by using this form, contacting her at: drhellen@drhellengreenblatt.info or feel free to call her at:  302.265.3870 (ET, USA).
www.niams.nih.gov/health_info/lupus/lupus_ff.asp
www.hindawi.com/journals/bmri/2011/432595/
www.ncbi.nlm.nih.gov/pmc/articles/PMC3320801/
www.ncbi.nlm.nih.gov/pubmed/28507328
www.hopkinslupus.org/lupus-treatment/lupus-medications/antimalarial-drugs/
www.ncbi.nlm.nih.gov/pubmed/28521867
www.ncbi.nlm.nih.gov/pubmed/28491039
www.ncbi.nlm.nih.gov/pubmed/28477898
www.ncbi.nlm.nih.gov/pubmed/28432856

 

The second leading cause of death for people under the age of 44 years is suicide. Overall, it is the the tenth leading cause of death in the United States, with veterans comprising 22.2% of this statistic.  Women are three times more likely to attempt suicide, but for every woman who takes her own life, four men will die from their attempt.

Although older adults make up only 12% of the population in the States, they account for 18% of all suicides. These fatal events in the elderly are probably under-reported by 40% with “silent suicides”, dehydration, “accidents”, medication over doses, etc. ending in death.  Additionally, double suicides involving spouses or partners occur most frequently in this population. Since the elderly are the fastest growing segment of the population, these later-life deaths are predicted to result in suicide becoming a major public health issue in the too-near future.

Inflammation and Suicide

C-reactive protein (CRP) is associated with high levels of inflammation found in people with inflammatory disorders, burn and trauma victims, in obese individuals, in people with infections or with cardiovascular disease. People with suicidal thoughts (known as suicidal ideation) or attempts, also exhibit high levels of C-reactive protein compared to people without such behaviors.

Inflammatory factors are triggered during stress and are associated with depression.

image

When compared to patients being treated for psychiatric disorders who are not suicidal, individuals who have contemplated or attempted suicide have increased levels of inflammatory cytokines, immune cell molecules in their blood and/or brain.

The ratio of inflammatory molecules to anti-inflammatory molecules in the body either promotes inflammation or limits it.  A healthy immune system constantly strives to maintain these factors in a delicate balance, in immune homeostasis. 

Importance of Balancing Immune Factors

Imbalances in immune regulators are harmful and lead to disease. Taking the following steps should make a major difference in helping the body and mind return to homeostasis, to its natural, healthy balance:

  • Engage in physical activity at least 30 minutes a day 5 days/week.
  • Add one or more daily servings of a superior immune support supplement to your diet.
  • Maintain a healthy weight.
  • Eat a wide variety of colorful fruits and vegetables.
  • Spend some time outdoors.

For decades I have helped people enhance their quality of life.  I can be contacted at: DrHellen@DrHellenGreenblatt.info, use this form or give me a call at 302.265.3870 (ET USA) and let us talk. Your first 30 minutes are on me!  You’ve tried everyone and everything else, let me help you feel good again, you deserve it!

 
afsp.org/wp-content/uploads/2016/06/2016-National-Facts-Figures.pdf

www.sciencedirect.com/science/article/pii/S1043466615300090

www.ncbi.nlm.nih.gov/pubmed/28211584

www.ncbi.nlm.nih.gov/pubmed/28135675

www.ncbi.nlm.nih.gov/pubmed/27824355

www.biologicalpsychiatryjournal.com/article/S0006-3223(14)00794-X/fulltext

An article in a recent trade publication opened with the following: “Charles couldn’t believe the intensity of the pain – and he had been shot during a tour in Iraq with the Marines. “I was lying in my sleeper and my big toe just went on fire. It was like nothing I had ever experienced. I thought I was going to pass out from the pain,” Charles explained. “My big toe was red, swollen and when I touched it, even a little, it hurt like hell”. Charles’ problem is that he suffers from gout.

 Gout is a type of arthritis that seems to run in families and results from the presence of crystals that form in the body. For example, during digestion and metabolism, the body produces uric acid which is eliminated via urine. Any uric acid that the body cannot excrete accumulates in the blood. For reasons not understood, about 30% of people with high levels of uric acid in their blood form needle-like, sharp urate crystals that end up in their joints and/or other parts of the body.

 Herbert Baraf, MD, Chevy Chase, MD, has a great analogy: “Imagine pouring packets of sugar into a glass of tea; can only hold so much in solution. And sooner or later, the sugar is going to start accumulating on the bottom of the glass.

 People with gout may go weeks or months without an attack, but when it flares up it can be excruciating and last for days. Over time, repeated attacks can eat into bone and cartilage, causing permanent damage to affected joints.

Inflammation

The presence of crystals triggers an intense inflammatory response and painful swelling the result of the body’s attempt to break down the crystals. Typically the crystals end up in joint cartilage, and for unknown reasons, especially the big toe.

gouty toe

In others, crystals settle in kidneys or the urinary tract, impairing their function or forming stones. White blood cells migrate into the joint spaces and fluids and the lubricating membranes that line the joints, the synovial membranes trying to eliminate the crystals. The immune cells attracted to the area release biological factors, cytokines and chemokines, into the surrounding area. This attracts more inflammatory cells with a result of redness, swelling and debilitating pain.

Certain immune factors are typically only in small amount in normal uninflamed joint fluids, but in individuals undergoing a gout attack (flare) the levels of the factors are significantly increased.

 Since inflammation is associated with many diseases, such as cancer, diabetes, obesity and cardiovascular health, it is not surprising to find that patients with gout are at higher risk of these diseases when compared to the general population.

 Summary:

Gout is caused by an overactive immune system using inflammation unsuccessfully to get rid of the crystals that are causing the discomfort.

Returning the immune system to balance, immune homeostasis, can result in a higher level of quality of life (QOL) for people with gout.

For years I have helped people promote  joint, digestive, energy and overall health.   Feel free to contact me DrHellen@DrHellenGreenblatt.info, use the form, or give me a call at 302.265.3870 (ET) and let us talk. Let me help you help yourself, it is  time!

www.nature.com/icb/journal/v88/n1/full/icb200999a.html
fleetowner.com/driver-management-resource-center/truck-drivers-crosshairs-gout
www.nytimes.com/2013/04/27/booming/why-do-i-have-gout.html
rheumatology.oxfordjournals.org/content/44/9/1090.short
www.hopkinsarthritis.org/ask-the-expert/heredity-and-gout/
www.uptodate.com/contents/gout-beyond-the-basics
www.internationaljournalofcardiology.com/article/S0167-5273(15)30342-9/abstract?cc=y=
www.ncbi.nlm.nih.gov/pubmed/28093417
www.ncbi.nlm.nih.gov/pubmed/25332119
www.hindawi.com/journals/mi/2015/680853/

 

Given all the current social, political and economic uncertainties, the holidays this year may be even more anxiety-producing and stressful than in the past. Past surveys have shown that 30-50% of people (and because of all of their responsibilities, especially women) experience heightened stresses during the holidays.

STRESS AND INFLAMMATION

Stress alters immune responses affecting our ability to fight infection and heal after injury. Inflammation is a necessary part of the immune response and is stimulated when the body is injured or exposed to pathogens or mutated cancer cells.

Short term stress stimulates the immune system by preparing it for a “flight vs. fight” response, but over a longer period of time stress results in negative imbalances of the immune system and increased inflammation. This becomes even a larger problem for people who are already in poor health or struggling with disease.

Poorly regulated  inflammation results in chronic diseases such as diabetes, arthritis, coronary heart disease, Alzheimer’s disease, dementia and even cancers, so it is important that the body carefully regulate the amount of inflammation produced.

Inflammation is a two-way street. Stress causes inflammation and inflammation causes stress.  And when the holidays or daily activities increase stress, the amount of inflammation produced by the body increases as well.

stress-and-inflammation

There are biological markers in the blood that track differences in immune responses.   The longer and greater the stress, the more likely the body is to switch from a healthy, controlled inflammatory response to one that affects its ability to fight disease and healing processes.

CONTROLLING INFLAMMATION AND STRESS 

The net effect of an inflammatory response is determined by the body balancing its inflammatory and its resulting anti-inflammatory responses.

Especially during the holidays, the four best ways to help the body balance are:

Be physically active for at least of 2.5 hours total per week.

  1. Incorporate a daily immune balancing supplement into your diet.
  2. Eat a smart, healthful diet.
  3. Keep your weight under control.

Remember:  The better you take care of your immune system, the better it will take care of you.

Graphic adapted from: Johanna Bendell, MD, with thanks.
www.psychcentral.com/holidays/
www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress/art-20047544
www.apa.org/news/press/releases/2006/12/women-stress.aspx
www.ncbi.nlm.nih.gov/pubmed/27859423
www.jci.org/articles/view/25102
www.ncbi.nlm.nih.gov/pubmed/12480495
www.ncbi.nlm.nih.gov/pubmed/24062448
www.ncbi.nlm.nih.gov/pubmed/27862176

 

Our heart is “simply” a large muscle that continuously pumps oxygen-rich blood throughout the body supplying cells, tissues and organs with life-giving oxygen and nutrients. The cells of the body release carbon dioxide and other gases as a by-product of producing energy. These gases are removed from the blood as it circulates through the lungs.

A heart attack results when blood is blocked from getting into the arteries that feed the heart. If not treated rapidly, parts of the heart muscle may die from lack of oxygen. After a heart attack, danger signals released by dying cells trigger inflammation which in turn attracts immune cells into the area to clear dead cells and tissue debris.

The high numbers of inflammatory immune cells stick to the plaque, increasing the risk for another heart attack. The body tries to heal itself by transforming the damaged heart muscle cells into scar tissue. Because scar tissue is hard and not flexible, a badly scarred heart cannot pump blood efficiently.

For any sort of healing, the body has to produce the right amount of inflammation. There has to be sufficient inflammation for the healing process, but not so much that excessive scarring occurs. Depending on how much scar tissue forms, congestive  heart failure may result due to the inability of the heart to pump normally.

Our cells produce cholesterol which is essential for a wide range of biological functions. The body has to manufacture the right amount of cholesterol and which has to go to specific parts of the body.   If too much cholesterol is produced over many years, cholesterol plaque builds up in the arteries resulting in atherosclerosis. Atherosclerosis is triggered by lifestyle issues that cause uncontrolled inflammation such as high blood pressure, smoking, poor dietary choices and excessive weight.

Plaque deposits narrow the passageways of arteries and block the flow of blood in vessels that feed the heart itself. The plaque may eventually harden, burst and release blood platelets that form clots in an attempt to stop the bleeding. The blood clots may cause even more blockages in the arteries, obstructing blood and oxygen flow and causing more heart damage. An artery to the heart which is blocked may result in a heart attack; a blocked artery in or leading to the brain results in a stroke.

 What is a Heart Attack?

 

In Summary:

1) Acting fast at the first sign of heart attack symptoms can save lives and limit damage to the heart. Heart attack treatment works best when it’s given right after symptoms occur. If you think you, or someone else is having a heart attack, even if you’re not sure, call emergency services immediately.

2) Current therapies for atherosclerosis and cardiovascular disease do not target inflammatory cells. Maintaining the body in immune homeostasis, immune balance, may help the body support healthy heart and cardiovascular function.

www.nhlbi.nih.gov/health/health-topics/topics/heartattack
www.heart.org/HEARTORG/Conditions/Inflammation-and-Heart-Disease_UCM_432150_Article.jsp#.V7un7mf6vcs
www.pnas.org/content/113/29/8212
www.ncbi.nlm.nih.gov/pubmed/27619160
www.ncbi.nlm.nih.gov/pmc/articles/PMC3375712
www.ncbi.nlm.nih.gov/pubmed/27515051
stm.sciencemag.org/content/8/342/342ra80www.ncbi.nlm.nih.gov/pubmed/27542099

 

 

Last week I talked with a young local Asian-American business owner who shared with me that he was “a little fatigued and stressed out”. I suggested that if he took steps to getting his immune system in balance, that since our physical and emotional well-being is dependent on homeostasis, he would feel much better.

He basically replied that, “he spends half the year in Florida, has a lot of friends that are “into” nutrition, he exercises and that he didn’t need any more information, thank you”.

Nothing like a person with an open mind, but unfortunately too many people think in this narrow way.  We all know individuals that eat nutritiously, exercise 5-7 days a week and watch their weight but they still do feel “off”.  Their fingers, elbows or knees hurt, they can’t eat everything they would like, or they have other health issues despite their “great” life style.

Nutritional Recommendations:

The evidence is strong that due to the hundreds of phytonutrients, plant nutrients, in fruits, vegetables, nuts, beans, whole grains and olive oil, that plant-based foods are important for our health. A broad variety of these phytonutrients are suggested since they appear to affect a wide-spectrum of biological functions. The consumption of plant-based foods influences the health of cells, blood pressure, risk of certain cancers, immune, dental, urinary, liver and gut health.

An additional dietary recommendation is to consume fish or fish oil 2-3 times a week for their omega-3 fatty acids. This “good” fat has multiple uses in our body, but the body cannot produced these fats by itself; we need an outside source.

Studies involving hundreds of thousands of people suggest that omega-3s reduce the risk of fatal heart disease, improve the flexibility of blood vessels, lower blood pressure and reduce immune inflammation. [Note: It is controversial whether omega-3 supplements are as beneficial as eating fish; in fact, they may cause certain health issues.]

Role of the Immune System

When the body is threatened by pathogens or cancer cells, or has been injured, the body responds with short-term inflammatory responses, acute inflammation.

Immune cells flood the area to destroy invading foreign organisms or cancer cells, or to start the healing process after trauma. If the body cannot get rid itself of the infection, or if it over-responds with excessive levels of inflammation, the immune response may become chronic, or long-term.

Chronic inflammation is abnormal and damages previously healthy tissues and organs. This sort of unlimited inflammation results in autoimmune diseases, diseases in which the body’s immune system turns on the body.  Conditions such as arthritis, diabetes, lupus, multiple sclerosis, Crohn’s disease, ulcerative colitis, celiac disease, hepatitis and asthma can result from such run-away inflammatory responses.

Knowledgeable individuals know that nutrition plays only an initial role in staying healthy. Good nutrition is the foundation upon which to build health, but it is NOT ENOUGH; it is the immune system that governs one’s health and must be optimized.

The Importance of a Balanced Immune System

Immune balance, immune homeostasis, is tightly regulated by the body. It allows the organism to respond to infection, cancer cells and injury with the right amount of inflammation.  Any imbalances, either too much stimulation, or too little, results in immune disorders and health issues.

The key to good health and healthy aging is keeping the immune system in balance.

    Scales Immune Reponses Partial

Dr.Hellen’s major passion is helping people to enjoy life at its fullest. She may be contacted by using this form, at: drhellen@drhellengreenblatt.info or feel free to call:  302.265.3870 (ET, USA).

  

nutrition.ucdavis.edu/content/infosheets/fact-pro-phytochemical.pdf
www.hsph.harvard.edu/nutritionsource/fish
www.harvardprostateknowledge.org/high-intake-of-omega-3-fats-linked-to-increased-prostate-cancer-risk
www.ncbi.nlm.nih.gov/pubmed/17047219?dopt=Citation
www.ncbi.nlm.nih.gov/pubmed/22893204
www.ncbi.nlm.nih.gov/pubmed/22122770
www.ncbi.nlm.nih.gov/pubmed/27357102

 

STROKE IS AN EMERGENCY- CALL 911

Posted on Monday, May, 30th, 2016 by Dr. Hellen in Immune Homeostasis (Immune Balance) | Inflammation | Stroke

Strokes are the third leading cause of death in the United States with a person dying every four minutes.  Strokes happen at any age, but the risk of having one doubles each decade after the age of 55.  Additionally 53% of stroke survivors may end up permanently disabled.

Active neurons, brain cells, require a constant flow of oxygen and nutrients which are supplied by blood vessels. A mere 60 second interruption of blood flow may result in the death of two million brain cells. Such events probably account for the significant number of disabilities experienced by stroke victims.

What Exactly is a Stroke?

87% of all strokes occur when blood flow is blocked by a blood clot in an artery in the brain. This type of “brain attack” is termed an ischemic stroke and if blood flow is not restored quickly enough may lead to significant damage or death of brain cells.

A second type of stroke, the hemorrhagic stroke, results from the rupture or leakage of weakened blood vessels in the brain. Blood spills into and around the brain triggering significant inflammatory and other immune responses as the body tries to “clean up” the blood. Even though only 15% of all strokes are hemorrhagic, they are responsible for about 40% of all stroke fatalities.

[Some individuals experience a quick, temporary blockage of blood flow to the brain, a “mini-stroke”. These transient [momentary] ischemic attacks, TIAs, result in no permanent injury to the brain, yet should serve as a warning of a possible future stroke.]

Identify a Stroke and Save a Life.

Identifying quickly whether a person is having a stroke can save their life or prevent them from a lifetime of disabilities.  Stroke is largely treatable – but time matters. Every second counts in getting help. The faster people are treated, the more likely they are to recover without permanent disability.

The symptoms to look for make up the letters B_E_ F_A_S_T. *

BALANCE:   Is the person experiencing a loss of balance?

EYES:         Has the person lost full or partial vision in one or both eyes? Is their vision blurry or double?

FACE:         Ask the person to smile. Does one side of the face droop?

ARMS:        Have the person raise both arms up — does one arm drift downward?

Are they experiencing weakness in one or both arms?

SPEECH:   Is the person’s speech slurred or having difficulty finding words?

Can they repeat a simple phrase without sounding slurred or  strange?

TIME:     Time is of the essence! Getting help fast is key to preventing brain loss or death.

If they have any of these symptoms, call 911 immediately, even if the symptoms disappear. The faster a stroke victim gets to the hospital, the better the chance of a successful recovery without life-limiting or even fatal results.

(The American Heart Association advises the public to NOT take aspirin during a stroke, since ruptured blood vessels may bleed even more.)

 Stroke and Inflammation

When stroke occurs, the nerve cells in the affected part of the brain die and immune cells rush into the area to clean up the dead cells.

This inflammatory response is essential to forming new nerve cells and for repair and healing, but uncontrolled inflammation can lead to further damage to the brain. As is always the case, immune homeostasis, the right balance of inflammatory responses, is needed for a rapid and complete recovery.

 

A Personal Note:

Through the years, many whom I have advised to balance their immunological responses, have recovered at a significant level after their stroke. Of course, their recoveries may have been coincidental to immune re-balancing, but it certainly is prudent to strive for immune homeostasis, immune balance, when healing.

 

Dr. Hellen is available at 302.265.3870 (EST, USA) for discussions as to the role of immune homeostasis for optimum health.  There is no charge for the first 30 minutes of the consult.  She may be contacted at: drhellen@drhellengreenblatt.info, or use the contact form. 

 * Thanks to nyp.org
www.ncbi.nlm.nih.gov/pmc/articles/PMC2858674/
www.ncbi.nlm.nih.gov/pmc/articles/PMC1868538/
stroke.ahajournals.org/content/44/6_suppl_1/S74.full
www.heart.org
www.stroke.org/understand-stroke/what-stroke/ischemic-stroke
www.ncbi.nlm.nih.gov/pubmed/27076418
www.nhlbi.nih.gov/research/reports/2005-cvd-events/howard
www.nih.gov/news-events/news-releases/scientists-identify-main-component-brain-repair-after-stroke
www.nature.com/neuro/journal/v18/n12/abs/nn.4146.html
www.telegraph.co.uk/science/2016/04/15/stroke-treatment-to-fight-inflammation-could-harm-recovery

Her dear friend’s last words to her were:

“This is horrible, I can’t breathe, I don’t want to suffer like this”.  She went on to say: “If you smoke and have COPD, let me describe to you what it’s like to live with COPD” [chronic obstructive pulmonary disease].”
  
“Pinch your nose, and put a bar straw, in your mouth. That’s one of the tiny straws they give you to stir a mixed drink. Now pinch your nose and only breathe in an out through the straw. Don’t cheat.”
 
“NOW, walk up and down the stairs about 3 or for times, Walk up and down a driveway, remember breathe only through the tiny straw. That’s what moving around and breathing is like for someone with COPD. It’s living hell! Supplemental oxygen doesn’t help much, and the medications only work during the early stages.”
 
“I have lived eleven years breathing like this. NO, I never thought this would happen to me, but it did, and it WILL probably happen to you too if you continue to smoke. SO IF YOU SMOKE STOP, do whatever you can to STOP, just STOP.

Although I have taken the liberty of modifying my friend’s statements slightly, sharing her personal comments hopefully brings a greater appreciation of the seriousness of having chronic obstructive pulmonary disease (a condition which most often the result of smoking and/or exposure to air-borne chemicals).

Internationally, chronic obstructive pulmonary disease (COPD) is the one of the leading cause of death (vying with HIV) and it is the third leading cause of death in the United States. There was a time that individuals were not aware of the dangers of smoking and as these people age, their rates of death from COPD are on the increase. Additionally, people are living longer, so more patients experience physical declines leading to disability and often, premature death.

Chronic obstructive pulmonary disease is the result of the walls of the alveoli, the balloon-like air sacks of the lungs becoming stiff and losing the ability to transfer oxygen from the lungs to the blood stream.  Also inflammatory mucus is produced in large amounts which blocks air from moving through the lung’s air passages.

Until recently, pulmonologists (lung doctors), did not recognize COPD as being caused by inflammation.  They are now convinced thatparticulates in cigarette smoke and other airborne chemicals trigger immune, inflammatory cells to “clean-up” the toxic materials. [Please see previous article on smoking.]

Over time, the inflammatory responses of the body destroy healthy lung tissue resulting in labored breathing, along with a greater susceptibility to frequent respiratory infections.

Unfortunately people with COPD treated with inhaled steroids are at greater risk of getting pneumonia and other respiratory diseases.  Additionally, individuals with HIV have greater decreases in lung function than individuals without COPD.

When a person has chronic obstructive pulmonary disease, their lungs suffer from unchecked inflammation. Control the amount of inflammation being produced, and their quality of life will change for the better.

If you want to change how you feel, contact Dr. Hellen. There are no fees for the first 30 minutes of consultation. She may be  contacted by using this form or calling:  302.265.3870 (ET, USA).

 

 http://www.ncbi.nlm.nih.gov/pubmed/23603459
http://www.betterhealth.vic.gov.au/health/conditionsandtreatments/lung-conditions-chronic-obstructive-pulmonary-disease-copd
www.ncbi.nlm.nih.gov/pubmed/27019597
www.ncbi.nlm.nih.gov/pubmed/20513910
www.nature.com/articles/nrdp201576
www.ncbi.nlm.nih.gov/pubmed/26974304

As of this writing, the Centers for Disease Control (CDC) in Atlanta is strongly recommending that pregnant woman postpone travel to many countries across the world, including the popular Caribbean islands.  The CDC is taking these steps due to the possibility that these women may become are infected with a mosquito borne virus called Zika.  The World Health Organization (WHO) Director General Dr Margaret Chan, has said that Zika had gone “from a mild threat to one of alarming proportions” and expects the virus to spread through the Americas and affect between three million and four million people.

Eighty percent of individuals who are infected with Zika do not show symptoms.  However, when symptoms do occur, they can last up to a week or so and include fever, rash, pink eye, and joint pain. Some clinicians suggest that Zika virus infection may result in the autoimmune [against oneself] condition,  Guillain-Barre syndrome (GBS).  This is rare disorder where too much inflammation damages the nerve cells, causing muscle weakness and may lead to paralysis.

The greatest concern however right now is that health agencies “strongly suspect” that when a pregnant women is bitten by a mosquito that is carring the virus, that even if she does not experience symptoms, that her offspring may develop brain malformations.

This latest outbreak adds to concerns that infectious diseases are one of the top threats challenging our world—a major topic on the agenda of last week’s World Economic Forum world leader attendees.  Until vaccines or treatments are developed, viral infections such as Zika, Ebola, SARS (severe acute respiratory syndrome), and MERS (Middle East Respiratory Syndrome) remain a threat to the world’s population.

Currently, there are no commercially available vaccines or treatments for Zika.  Until recently the cost to develop a successful vaccine was far greater than what the manufacturers would recoup in vaccine sales.  However, development of a vaccine for Zika will likely now escalate since Zika has spread so widely, infecting over 1.5 million individuals and its being linked to neurological problems, especially in newborns.

In addition to a lack of vaccines and treatments for a multitude of viral diseases, another significant health-care crisis we are facing is treatment of infection by anti-microbial-resistant pathogens. As Dr. Keiji Fukudaof the World Health Organization has stated:  “We really hope to pull the world back from the brink where antibiotics don’t work anymore”.

When bacteria are stressed, for example by a killer antibiotic, their genetic material may change, mutate, so that they can tolerate and become resistant to such compounds.  The bacteria can then replicate easily and outgrow bacterial strains that were not resistant to the antibiotic.

Fifty percent of antibiotic prescriptions written by U.S. physicians are of no benefit to the patient, and when used to fatten livestock and poultry it gives bacteria even more opportunity to acquire antibiotic tolerance.

It is our immune systems that identify, destroy, and remove invading pathogens.   When our body recognizes that it has been invaded by foreign agents, a strong inflammatory responses is triggered to meet the onslaught of the pathogens.  White blood cells accumulate in the area to combat the invaders.  These immune cells release cytokines and other immune messages  recruiting more white blood cells in an attempt to “burn out” the infection. Without a powerful inflammatory response, we cannot limit or survive infections.

In the absence of drugs or treatments that prevent and control the growth of viruses and other microorganism the immune system must be optimized to protect the body against them.

 

www.cdc.gov/mmwr/index.html
www.scientificamerican.com/article/who-extremely-alarmed-by-zika-cases-could-reach-4-million/?WT.mc_id=SA_DD_20160128
www.wsj.com/articles/health-threats-spur-vaccine-hunt-1453337493
ecdc.europa.eu/en/healthtopics/zika_virus_infection/factsheet-health-professionals/Pages/factsheet_health_professionals.aspx
www.vox.com/2016/1/20/10795562/zika-virus-cdc-mosquitoes-birth-defects
www.wsj.com/articles/SB105768561135341800
www.cdc.gov/features/antibioticresistancethreats/
www.cdc.gov/media/dpk/2013/images/untreatable/img2_sm.jpg
www.bbc.com/news/health-35427493
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