Anti-Inflammatory/Anti-Aging Strategies
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From the time of the ancient Greeks, it has been clear that the mind-gut-body connection influences one’s health; however, only during the last century have we begun to understand why this is the case.

With new tools, scientists can show that there is cross-talk between the brain, the gut and the immune system.  Immune molecules from white blood cells send messages to the brain and the gut and in turn, these organs signal back to the immune system, up-regulating (increase) or down-regulating (decrease) inflammation.

 Image stress stomach immune system brain

©2017 Dr. H. C. Greenblatt

Chronic, long-term stress, affects immune cells by changing their gene activity.  This prepares them to fight infection or trauma and increases inflammation. More immune cells are then enlisted for the fight, resulting in increased inflammation.

Inflammation is necessary for survival, but too much inflammation is linked to heart and autoimmune disease, diabetes, depression, and cancer.  This is why it is essential to maintain the right balance of signals.

Stress responses are part of a vicious cycle in which stress triggers inflammation and inflammation triggers additional stress.

In stressed mice, there are four times the numbers of immune cells than found in non-stressed mice.  Additionally in mice that are stressed 1100 genes are responsible for increasing (up-regulating) inflammation.  These genes in non-stressed mice are not activated.

Similar outcomes are seen in humans under chronic stress. For weeks and months following natural disasters such as earthquakes and hurricanes,  individuals, especially those who have suffered great personal loss, have imbalances of the immune system that affects them both physically and emotionally.

The immune system and its inflammatory responses are in exquisite balance (homeostasis).  The body expands much of its energy maintaining its balance in a steady state.  This may be the reason that people who are stressed out tend to be “tired a lot of the time”.

Let us say that your immune system consists of 30 billion cells and that 15 billion of these cells are in the attack mode with excessive inflammation (up-regulation).  Let us propose that another 15 billion cells are trying to limit the inflammatory response (down-regulation).

A total of 30 billion cells expending a “trivial” amount of energy is a great deal of wasted energy. No wonder people become exhausted when they are not in homeostasis, balance.

CONCLUSION:

The key to reducing stress  is to help the immune system return to homeostasis, to its natural balance.

To better manage stress especially during the holidays:  incorporate an immune support supplement into your daily diet, be physically active 2-2.5 hours/week, spend time outdoors, eat smart, stay within healthy weight limits and remember that you are only one person—be kind to yourself; give yourself a break.

Achieving immune homeostasis will make all the difference in the quality of your emotional and physical well-being. 

Contact Dr. Hellen at: DrHellen@DrHellenGreenblatt.info, use the form or give her a call at 302.265.3870 (ET, USA) at no charge to you. 



http://www.uppitysciencechick.com/glaser_stress_immune_dysfunction.pdf
www.ncbi.nlm.nih.gov/pubmed/29064542
www.ncbi.nlm.nih.gov/pubmed/27319971
www.ncbi.nlm.nih.gov/pubmed/24608036
www.ncbi.nlm.nih.gov/pubmed/22790082

What is the Role of Inflammation?
When the body is injured or recognizes the presence of pathogens such as bacteria, viruses, molds, parasites or cancerous cells, its immune system is triggered to respond with inflammation to “burn” the threat out of the body.

Balance is Essential
Once the challenge has been met, a person in immune balance, homeostasis, will reduce the amount of inflammation that they are producing to “normal” levels. Uncontrolled, run-away  inflammation leads to autoimmune diseases (against oneself) in which its own tissues and organs are attacked.

Lupus
Systemic lupus erythematosus (SLE), lupus, is a complicated autoimmune condition affecting virtually every organ in the human body. Because of the wide-range of symptoms experienced, the disease is often difficult to diagnose. Common symptoms are extreme fatigue, swollen and/or painful joints, muscle pain, low-grade fever, thinning or loss of hair, butter-fly shaped rash across the nose and cheeks, chest pain when taking a deep breath, kidney and heart problems.

Butterfly rash

“Butterfly Rash” often associated with SLE
(
emedicine.medscape.com)

 

Females make up 80-90% of people with lupus and despite treatment, many individuals will experience flares and remissions (symptoms come and go) their entire lives.

Lupus and Inflammation
The hallmark of lupus is over-activity of the immune system and inflammation. Imbalances of inflammatory immune factors, cytokines, are significantly higher in lupus patients compared to people without lupus. These immune molecules promote inflammation and damage tissues.  High levels of these inflammatory factors are associated with the severity of disease but decrease as individuals are successfully treated.

Anti-malaria medications originally used to prevent or treat malaria has been used to treat lupus.It was not understood why these medicines were somewhat effective against SLE, but a recent study suggests that these medications inhibit inflammation.

Physical Activity
Every time a muscle contracts, it releases anti-inflammatory molecules that helps the body balance the amount of overall inflammation produced.

As would be predicted, weekly physical activity improves fatigue, depression and increases the quality of life of most individuals. Even moderate exercise, 3 days a week for 20 minutes, has been shown to make a major difference in the amount of energy and feelings of well-being experienced by lupus patients.

If  You Have Lupus
Frequent physical activity, eating in a healthful manner and daily consumption of an excellent immune balancing supplement helps the body control inflammation and achieve immune homeostasis (immune balance).

Dr.Hellen is passionate about helping people enjoy life at its fullest. She may be contacted by using this form, contacting her at: drhellen@drhellengreenblatt.info or feel free to call her at:  302.265.3870 (ET, USA).
www.niams.nih.gov/health_info/lupus/lupus_ff.asp
www.hindawi.com/journals/bmri/2011/432595/
www.ncbi.nlm.nih.gov/pmc/articles/PMC3320801/
www.ncbi.nlm.nih.gov/pubmed/28507328
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www.ncbi.nlm.nih.gov/pubmed/28521867
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www.ncbi.nlm.nih.gov/pubmed/28432856

 

Given all the current social, political and economic uncertainties, the holidays this year may be even more anxiety-producing and stressful than in the past. Past surveys have shown that 30-50% of people (and because of all of their responsibilities, especially women) experience heightened stresses during the holidays.

STRESS AND INFLAMMATION

Stress alters immune responses affecting our ability to fight infection and heal after injury. Inflammation is a necessary part of the immune response and is stimulated when the body is injured or exposed to pathogens or mutated cancer cells.

Short term stress stimulates the immune system by preparing it for a “flight vs. fight” response, but over a longer period of time stress results in negative imbalances of the immune system and increased inflammation. This becomes even a larger problem for people who are already in poor health or struggling with disease.

Poorly regulated  inflammation results in chronic diseases such as diabetes, arthritis, coronary heart disease, Alzheimer’s disease, dementia and even cancers, so it is important that the body carefully regulate the amount of inflammation produced.

Inflammation is a two-way street. Stress causes inflammation and inflammation causes stress.  And when the holidays or daily activities increase stress, the amount of inflammation produced by the body increases as well.

stress-and-inflammation

There are biological markers in the blood that track differences in immune responses.   The longer and greater the stress, the more likely the body is to switch from a healthy, controlled inflammatory response to one that affects its ability to fight disease and healing processes.

CONTROLLING INFLAMMATION AND STRESS 

The net effect of an inflammatory response is determined by the body balancing its inflammatory and its resulting anti-inflammatory responses.

Especially during the holidays, the four best ways to help the body balance are:

Be physically active for at least of 2.5 hours total per week.

  1. Incorporate a daily immune balancing supplement into your diet.
  2. Eat a smart, healthful diet.
  3. Keep your weight under control.

Remember:  The better you take care of your immune system, the better it will take care of you.

Graphic adapted from: Johanna Bendell, MD, with thanks.
www.psychcentral.com/holidays/
www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress/art-20047544
www.apa.org/news/press/releases/2006/12/women-stress.aspx
www.ncbi.nlm.nih.gov/pubmed/27859423
www.jci.org/articles/view/25102
www.ncbi.nlm.nih.gov/pubmed/12480495
www.ncbi.nlm.nih.gov/pubmed/24062448
www.ncbi.nlm.nih.gov/pubmed/27862176

 

Parkinson’s is a disease of the nervous system that affects mobility, memory, and cognition.  Individuals may eventually experience rigid muscles, tremors of the limbs and head, loss of muscle control, monotonous speech levels, and a slow, shuffling gait.

Individuals tend to develop the disease as they age. Having a close relative with Parkinson’s disease (PD) increases the likelihood of developing Parkinson’s, with men more than 1.5 times more likely to develop the disease than females.

Although the causes of Parkinson’s disease are not clear, a recent study suggests that individuals with a specific gene are at a higher risk of getting Parkinson’s disease if they were exposed to pyrethroids, a class of chemicals found in the majority of household insecticides.  Exposure of individuals to these pesticides may result in brain tissue inflammation.

Inflammation and Autoimmune Responses

In Parkinson’s disease, the body mounts an inflammatory response against its own brain cells, its dopaminergic neurons. (An immune response against oneself is called an autoimmune response.)

These specialized brain cells produce a biochemical called dopamine with many functions including controlling bodily movements, memory, ability to think, mood, and learning.  The body’s long-lasting inflammatory response against its own nervous cells gradually destroys the dopaminergic neurons resulting in abnormal dopamine levels and brain activity, symptoms associated with Parkinson’s disease.

Microglial cells are specialized immune cells located in the brain. They are considered the “canary in the mine”.  When microglial cells sense a threat, they become “activated” and release immune factors that may, depending on the types and amounts of these molecules, be beneficial or cause damage to nerve cells.

Activated microglial cells are found in large numbers in the brains of Parkinson’s patients, along with high levels of cytokines, biochemical molecules responsible for inflammation.

The brain and spine of the nervous system are cushioned by cerebrospinal fluid. This fluid helps to provide nutrients to the nervous system and removes waste products from the brain.

Individuals with Parkinson’s disease have high levels of immune inflammatory molecules in their spinal fluid.  The more concentrated the molecules, the more likely the person is to severe fatigue, depression, and cognitive impairment.

Summary

Certain genes that control immune system responses are also strongly linked with the development of Parkinson’s disease.

Increasingly, scientific studies suggest that inflammation and autoimmune responses result in Parkinson’s disease.

Helping the body limit out-of-control inflammation, and achieving a more homeostatic, more balanced immune response, may go a long way towards changing the quality of life in individuals with Parkinson’s.

Feel free to contact Dr. Hellen. There is no fee for speaking with her. Dr. Hellen may be contacted by using this form or at: 302.265.3870 (ET).

 www.nature.com/npjparkd/
www.sciencedirect.com/science/article/pii/S1357272504003711
physrev.physiology.org/content/91/2/461
www.ncbi.nlm.nih.gov/pubmed/25757798
www.ncbi.nlm.nih.gov/pubmed/25769314
www.ncbi.nlm.nih.gov/pubmed/22166438
www.ncbi.nlm.nih.gov/pubmed/25215472
www.ncbi.nlm.nih.gov/pubmed/22814707
www.medicalnewstoday.com/articles/265378.php

This month was the 13th anniversary of the haunting September 11 event that has changed us, our Nation, and the world we thought we knew. It seems like yesterday that these events happened.

Three years ago, I posted my frustration of my inability to get First Responders, and/or their health practitioners, to consider addressing the issue of immune homeostasis, immune balance, to enhance the quality of life of individuals that had put themselves at risk to save others.

 Exposure to Air-Borne Particles

The World Trade Center Health Registry estimates about 410,000 people were exposed to air-borne particles and toxins attempting to rescue survivors and recover the dead, clearing the site, or cleaning the surrounding buildings.

 Despite the fact that early in the World Trade Center (WTC)’ construction, builders abandoned asbestos as a fireproofing material, over 400 tons of asbestos were used in the building of the World Trade Center (WTC). Additionally ”mineral wool”, minerals that were melted and spun into fibers and bound together by cement like components was used in construction.

 Massive amounts of hazardous fiber, asbestos, glass, gypsum, and cement were pulverized into ultra-fine particles when the Towers imploded and collapsed on September 11. Virtually every surface was covered with a fine, white particulate dust, and downwind from the complex, the fine particulate matter settled to a depth of 3 inches or more.

Affected groups of Responders include firefighters, police, health professionals, clean-up crews, construction workers, truck drivers, transit workers, lower Manhattan residents, and office workers.

 Increase Risk of Cancer

Responders were exposed to hundreds, if not thousands, of toxic particulates, dust, and gases at Ground Zero. As many of these are known to be potential carcinogens, it is not surprising that two years ago, 58 different types of cancers were added to a list of diseases with which many World Trade Center responders suffer.

 Overall, First Responders at Ground Zero have a 15% increased cancer risk with a 239% higher risk for thyroid cancers. However, unfortunately, asbestos-related lung cancers such as malignant mesothelioma may not appear for 20-40 more years.

 Signature Illness: PSTD and Respiratory Illness

If having a significant increase in cancer risk was not enough, according to the findings of the Stony Brook [NY] Medicine’s World Trade Center Health Program, as many as 60% of 9/11 World Trade Center responders continue to experience “clinically significant symptoms of post-traumatic stress disorder (PTSD) and … respiratory illness”.

Coughing and breathing problems have been a major issue, even in Responders that were only “moderately” exposed. Additionally individuals with the most exposure were more likely to find that their asthma symptoms became worse.

Benjamin Luft, MD, Medical Director of the Stony Brook Program is of the opinion that “a signature illness” of a WTC Responder is having both PTSD and respiratory problems at the same time.

 Respiratory Difficulties and Inflammation

Inflammatory biomarkers have been monitored in those exposed to WTC dust and smoke. Elevated levels soon after exposure were associated with increased risk of difficulty breathing in the years that followed.

 PTSD and Inflammatory Responses

A few months ago I stated “Clinical studies suggest that individuals with post-traumatic stress disorders suffer from chronic low-level inflammation. This is reflected in their greater propensity to have inflammation-associated diseases such as autoimmune, cardiovascular, gastrointestinal, musculoskeletal, and respiratory diseases.”

 “…individuals with PTSD are more likely to have significantly higher amounts of circulating CRP [an inflammatory marker] than those not diagnosed with PTSD.”

 The Combination of PTSD and Respiratory Issues

To repeat from my previous post,“The immune system mounts an immune, inflammatory response when the body is exposed to pathogens, pollutants, or toxins. The inflammatory cells release immune factors, such as cytokines, cellular messages, that are involved in cell-to-cell communication with the “purpose” of recruiting more inflammatory cells into an area to help eliminate a perceived threat.”

 “Pollutants and chemicals … trigger airway inflammation and increase mucous production. Other immune molecules cause narrowing of airways resulting in the contraction of the muscles lining the airways. The combination of inflammation and increased mucous makes it difficult for air to enter or leave the lungs and can result in breathing issues.”

“Additionally, lungs that do not function properly, are ideal for the multiplication of molds, bacteria, and viruses. The lungs continue their struggle to eliminate pollutants and pathogens, resulting in a chronic, persistent, dry cough and worsened lung function.”

 A Plea to Readers

I am convinced that immune inflammatory imbalances contribute in large portion to the reason that that First Responders experience so many health challenges.

 It is my heart-felt hope and expectation that helping individuals return to immune homeostasis, immune balance, may be the key to changing their quality of life. Despite numerous attempts and avenues, I have been unable to make reliable contact with decision makers or Responders.   I hope that you will forward my note to individuals that are still suffering the consequences of serving others.

 I can be reached at: DrHellen@DrHellenGreenblatt.info or at 302.265.3870. Thank you.

www.asbestos.com/world-trade-center/
sb.cc.stonybrook.edu/news/general/140910wtc.php
911research.wtc7.net/wtc/evidence/dust.html
www.sciencedaily.com/releases/2014/09/140910185910.htm
www.health.ny.gov/environmental/investigations/wtc/health_studies/responders.htm
www.cnn.com/2013/09/11/health/911-cancer-treatment/
www.thelancet.com/themed-911
www.mesothelioma.com/blog/authors/barbara/help-running-out-for-911-first-responders.htm
www.ncbi.nlm.nih.gov/pubmed/21998260

Exposure to chronic constant emotional or physical stress triggers a vicious cycle of inflammation. The stress increases the amount of inflammation that the body generates, and the additional inflammation “feeds” more stress.

Depressed individuals report that they experience high levels of tension and anxiety, fatigue, muscle discomfort, and/or gastrointestinal problems. Often they have a feeling that “something is very wrong”, but they cannot pinpoint what is bothering them.

Individuals suffering from depression often start by visiting physicians that specialize in specific organ systems of the body. For example a neurologist (specialty in the nerves), a gastroenterologist (digestive system), or a psychiatrist (medical doctor) or a psychologist, practitioners specializing in mental disorders. Unfortunately, most of these experts tend to focus on a single part of the body.

Since the human body is a single organism, and all the organ systems are integrated, it might be useful to realize that there is substantial and constant cross talk between all the organ systems of the body. Affect one part of the body and it has a ripple effect on all the other parts of the body.

As an example, when individuals are depressed, their immune cells produce large amounts of inflammatory molecules, pro-inflammatory cytokines, which circulate throughout the body. Since cytokines act in a hormone-like fashion, they affect all parts of the body and the brain.

Treatment Resistant Depression
Over seven million individuals with depression find little or no relief that prescribed antidepressant medications. A significant number of these patients have high levels of inflammatory cytokines, immune messages that result in inflammation. These inflammatory cytokines can interfere with the actions of medications.
Lifestyle Changes.

Too many individuals are convinced that only prescription medications can make a difference in their depression and anxiety. However, there are certain life style changes that may help them, with their clinician’s approval, decrease their medication.*

(*Note: The following lifestyle changes should only be incorporated after consultation with a qualified health practitioner. If you are on prescription medications, especially for depression or anxiety, DO NOT REDUCE OR STOP ANY MEDICATIONS without consulting with the prescribing health practitioner.)

Some naturally oriented steps that one can take are:

EXERCISE:
Researchers at Duke University Medical Center, Durham, NC, found that a brisk 30-minute walk or jog three times a week may be just as effective in relieving major depression as are antidepressant prescription medications. Patients were assigned to three groups: antidepressant medications only, exercise only, or a combination of both medication and exercise. The scientists found that the exercise by itself was just as effective as medication and “was equally effective in reducing depression…” as were antidepressants.

One reason exercise may be so effective in reducing the inflammatory-depression cycle is that every time a muscle contracts, it releases anti-inflammatory immune cytokines that reduce inflammation and a help to decrease anxiety, and improve mood.
SUNSHINE AND FRESH AIR:
The amount of time subjects are exposed to sunlight is directly related to the amount of a specific inflammatory cytokine they produce, and depressed individuals show differing levels of the cytokine when exposed to light for varying amounts of time.
Moderate exposure to sunshine and fresh air may contribute greatly to feeling less depressed. This may “simply” be because when one is exposed to sunlight, vitamin D is produced by the body.

Vitamin D is more like a “hormone” than a purely nutritional element, since it affects hundreds of genes and is a powerful immune system regulator. Although still not definitively proven, individuals living in temperate areas may find that taking vitamin D3 supplements may prove helpful.

EAT SMARTER:
Increase the amount of fresh and colorful fruits and vegetables, beans, fish, and chicken. Limit non-nutritious “foods”, especially fried foods, sweets, sodas (diet or regular!), white rice, and pasta. Eating in a nutritional manner may help the body regulate its daily inflammatory responses.

CONTROL YOUR WEIGHT:
Fat cells, adipose cells, especially those around abdomen produce a wide range of inflammatory cytokines. As the size of the cells decrease, the amount of inflammation that the body produces decreases. Lowering inflammation helps an individual to return to their natural immune homeostasis, their natural immune balance.

OMEGA-3 FATTY ACIDS FROM FISH OILS:
Studies suggest that daily consumption of omega-3 fatty acids from fish makes a difference in depression. In a recent randomized double-blind placebo-controlled study of shift workers, supplementation with omega-3 was associated with a reduction in high sensitivity C-reactive protein (an inflammatory marker) and depression. In another study of women, the highest intake of omega-3 was associated with a 49% decrease in symptoms of depression. In the latter study, investigators suggested that omega-3 was triggering the production of anti-inflammatory compounds.

RETURN THE BODY TO IMMUNE BALANCE, IMMUNE HOMEOSTASIS:
Inflammation in the body is a normal and desired process that is part of the healing cycle and it is the primary method by which the body defends itself from pathogens. The key to good health is to help the body achieve the right level of inflammation, immune homeostasis. We want the body to produce enough of an inflammatory response to defend itself from pathogens and cancerous cells, but not so much inflammation that healthy tissues are damaged.

Hyperimmune egg has been shown to help the body return to immune homeostasis, immune balance. In a university, double-blind placebo-controlled trial (the gold standard of human trials), subjects consuming hyperimmune egg reported lower levels of moodiness, anger, and hostility. [Med Sci Sports Exer 2009 5:228].

SUMMARY
Chronic inflammation, brought about by an over-expression or lack of control of the normal protective mechanisms of the body, has been linked to range of conditions including depression.
Individuals who control inflammatory responses will have a much higher emotional and physical quality of life.

www.ncbi.nlm.nih.gov/pubmed/15694227
www.ncbi.nlm.nih.gov/pubmed/23873713
www.karger.com/Article/Fulltext/51732
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bit.ly/1enpcdi
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www.psychiatrictimes.com/depression/inflammation-and-treatment-resistance-major-depression-perfect-storm

Endometriosis* is a painful, hormonal and immune system disease in which tissues similar to the mucous membranes lining the uterus (endometrium), end up in “strange” locations, places that these sorts of tissues are not typically found. The pockets of tissue react to monthly surges of estrogen and progesterone just like the uterus. These cells can be found, for example, outside the uterus, around the ovaries, fallopian tubes, the abdominal cavity, bladder, cervix, or bowels, and can become irritated and inflamed during the reproductive cycle. Eventually the condition may result in scarring and adhesions, abnormal tissue that binds organs together like a spider web.

Autoimmune Contribution?
Some scientists suggest that in endometriosis the immune cells of the woman are unable to recognize the presence of these “displaced” tissues and that the cells are not destroyed as they normally would be. Women with endometriosis, besides having greater inflammatory responses, often produce autoantibodies (antibodies against healthy tissue) and immune factors that lead to inflammatory conditions.

Endometriosis is a complex disease in which many factors, including genetic, one’s anatomy, and one’s environment all contribute to the problem. Endometriosis is associated with a disrupted inflammatory and hormonal environment in which growth factors and immune factors, such as cytokines, exist at increased levels. Women with endometriosis may exhibit excessive growth of blood vessels and nerve cells in their pelvis, which may “feed” the pain.

Symptoms
Endometriosis may be accompanied by heavy bleeding at anytime during the menstrual cycle, with severe pain becoming especially acute during menstruation. Pain and cramping may begin before, and extend several days into a women’s menses, and she may experience lower back and abdominal pain, bloating, diarrhea, fatigue, and malaise. Pain may be present during or after sex, and with urination, or bowel movements.

The severity of the pain experienced is an unreliable indicator of the extent of the condition. For example, women with mild endometriosis may have extensive pain, while others with advanced endometriosis may experience little or no pain.
Endometriosis can develop in girls as young as eight, or years after the onset of menstruation. While many women find that symptoms of endometriosis temporarily stop during their pregnancy, and/or completely with menopause, this is not always the case.

The main complication of endometriosis, besides excruciating pain, is infertility. Thirty to fifty percent of women suffering with endometriosis have difficulty getting pregnant.

Inflammation
Endometriosis is associated with an inflammatory environment of the pelvis. Different types of cytokines, immune factors, and growth factors are elevated in these individuals. For example, IL-8 is an inflammatory cytokine associated with inflammatory responses. The amount of Il-8 present in the body is strongly correlated with the severity of the disease, and contributes to the formation of adhesions.

Lean vs. Obese Women
In a study of younger women, the risk of endometriosis later in life was 40% lower in morbidly obese women as compared to lean women. The latter group had a nearly 3-fold greater risk of developing endometriosis than the obese women. This finding is contrary to expectations, since typically, obese women are at greater risk of inflammatory-mediated diseases than leaner women, and therefore would be expected to be at greater risk of developing endometriosis.

 [As an aside, heavy women that engage in regular, moderate to vigorous physical activity, lower their risk for endometrial cancer and other diseases. This result is expected, since every time muscle cells contract, they release potent anti-inflammatory molecules which balance the amount of inflammation generated by fat cells.]

Toxic Chemical Exposure
Dioxin is a toxic byproduct of industrial and consumer processes that involve chlorine or incineration of chlorine-containing substances, such as PVC, polyvinyl chloride, commonly known as “vinyl” plastics.

Exposure to dioxin and dioxin-like compounds have been shown to disrupt immune and hormonal balance and such chemicals have been implicated in the development of endometriosis and other diseases.

Non-Clinical Approaches
Physicians commonly recommend surgery and pharmaceutical approaches for endometriosis, but “alternative” approaches have been found to be helpful to others. For example acupuncture has been shown to be an effective pain treatment for some individuals. Additionally, eating a healthful diet, regular exercise, and certain amino acids may prove helpful.

Personal Note
I would be negligent if I did not mention that over a decade ago, a young researcher from West Virginia reported to me that a large number of women in a West Virginia community had been diagnosed with endometriosis. She was researching this problem, and unfortunately, she herself had endometriosis. I suggested a gradual introduction of a daily administration of 9-12 grams of polyvalent hyperimmune egg, a whole-egg protein from specially treated hens.

After a number of weeks the researcher reported back to me that her quality of life had improved dramatically. Unfortunately, I have lost contact with the investigator, so cannot report further on any changes she may have experienced.

Importance of Immune Homeostasis, Immune Balance
The key to endometriosis, as with most disease, is run-away inflammation. Therefore, achieving immune, inflammatory, homeostasis (balance) in individuals with endometriosis, may result in major differences in their quality of life.

Dr. Hellen can be contacted at: http://drhellengreenblatt.info/contact-dr-hellen/ or 1.302-265.3870 [USA, ET].

*Interested parties may contact support@endometriosisassn.org for a free information packet on endometriosis.

www.nmihi.com/e/endometriosis.htm
www.ncbi.nlm.nih.gov/pubmed/21054165
www.ncbi.nlm.nih.gov/pubmed/11949939
http://humrep.oxfordjournals.org/content/28/7/1783Share
www.endometriosisassn.org/environment.html
http://toxsci.oxfordjournals.org/content/70/2/161.full

 

TheseI grew up in a poor neighborhood in Brooklyn, NY. During the summers I spent most of my days sitting on the stoop, the front steps, reading piles of books that I carried home weekly from my local library, and watched people go by.

It hurt me, even at a young age, to see how hard it was for some people to get around. It broke my heart watching them as they struggled to get across the street. It seemed that everyone was in a hurry, beeping their horns, and telling them to “come on already!”. No respect for people who had dedicated their lives to working and bringing up children.

My father was known as the “Mayor” of Hopkinson Avenue, because if anyone needed his help, he was there. He was kind to people and animals. So perhaps this is why watching the older folks, I promised myself that I would make a difference in the lives of others.  This goal, of being of service to others, has governed my life.

I was lucky that The College of the City of New York, CCNY, had low tuition rates. Working during school breaks for the money I needed, I became the first person in my family to graduate from College, and staying within public education systems, eventually went on to get a PhD in the sciences from SUNY Downstate Medical Center in Brooklyn, NY.

My reasoning in becoming a scientist, rather than a medical physician, was that as the former, I might only affect the life of a patient one at a time, but as a scientist, my findings might help hundreds or thousands with a single approach.  And my hopes panned out, since I have been fortunate to help thousands change their quality of life.

To see comments of some folks for whom I have made a difference, please see http://drhellengreenblatt.info/notes . Some that I am reminded of:

A physician in Manhattan, NY had such significant fatigue and joint discomfort that she was forced to stop her practice and ended up in a wheelchair. Visits to other physicians, physical therapists, massage therapists, and other allopathic and complementary health practitioners did not change her quality of life. After our discussions about a protocol she might follow, she’s back in practice.

There’s Shirley F. who owns a charming restaurant on a scenic part of the Bay. Shirley does most of the preparation and cooking for her guests, but was finding it increasingly difficult to work in the kitchen. Chopping and cutting vegetables, fish, and meats was especially becoming harder and harder. Her fingers had become misshapen as well. Standing and walking around the kitchen and restaurant wasn’t becoming any easier either. After following my suggestions, Shirley found that she no longer had thoughts of giving up on her restaurant .

There’s Candy A. who had suffered from extreme gastrointestinal discomfort for years; nothing she tried made a difference. Within10 days of following my suggestion, Candy found that she was a new person.

These are just a few people who I have helped. You too deserve to feel better. It doesn’t cost you anything to talk with me. My passion is helping people improve their quality of life, naturally, and I would be delighted to help you as well. Feel free to contact me via phone 302.265.3870 (ET) or email me @ DrHellen@DrHellenGreenblatt.info.

Gut-associated lymphoid tissues are found in the walls of the intestine and contain billions of immune cells.  The white blood cells control the levels and types of bacteria that naturally populate the intestines.  The bacteria help to digest food that provides energy to the body,  and are part of the immune/bacterial ecosystem of the intestine.

 Interestingly, both immune cells and bacteria, protect the intestines from attack by pathogenic microorganisms, and cancer cells, and help heal the intestines when they are damaged.  Cross talk between the bacteria, and immune cells help the intestines maintain homeostasis, balance.  Each keeps the other in check.

 CELIAC DISEASE
Celiac disease is an intestinal, inflammatory, autoimmune (against oneself) disorder.  Individuals with celiac disease suffer from a wide-range of symptoms including diarrhea, fatigue, weight loss, inability to focus, skin and neurological issues, constipation, a feeling of being “bloated”, gas, anemia, headaches, osteoporosis (loss of bone density), and depression. 

 Ingesting grains, such as wheat, rye, and barley, which contain a component of protein called gluten, reportedly stimulate celiac disease.

 The presence of gluten stimulates sensitive immune cells to produce proinflammatory cytokines.  These immune messages drive inflammation, resulting in the destruction of the intestinal wall and symptoms.   Genetic, environmental, dietary, neuroendocrine, and immunological factors all contribute to disease progression.

 Currently, the primary guidance that celiacs get, is to go on a “gluten-free” diet.  Although it may be effective for some people,  such diets are restrictive, expensive, and do not work well for everyone.  In one study, every patient, 100% of those surveyed, in a cohort of 300 individuals, hoped for another option.

 OTHER APPROACHES
I often hear from people with autoimmune challenges such as celiac disease, “it’s genetic”.  Fine, so your genes are partially to blame. Meanwhile, what will you do? Continue to be uncomfortable?  So I ask those with inflammatory issues, why not consider short-term approaches until researchers discover longer-term solutions?  In three words: limit excessive inflammation.

 I like to describe inflammation as a way that the body “burns” out pathogenic microorganisms and cancer cells. The body must produce enough inflammation to protect itself from disease, and help the healing process, but not so much that healthy tissue, for example the intestinal lining, is damaged.

 Nutritional Approaches
Vitamin C and omega-3 fatty acids, from fish oil, inhibit the production of proinflammatory cytokines. (There is however,  evidence that vitamin A increases inflammatory processes.).

 Medical Approaches
Antibodies against specific inflammatory cytokines reduce intestinal injury in celiac disease, and the administration of corticosteroids, along with a gluten-free diet, was reported, in a small clinical trial, to provide benefit to celiac patients.

 Immunological Homeostasis/Balance
Hyperimmune egg, an ingredient that helps the body return to immunological balance, helps to support gastrointestinal health.  Many individuals with digestive issues report daily consumption of hyperimmune egg leads to major differences in their quality of life.

 LIMIT INFLAMMATION FOR BETTER HEALTH
The key to a higher level of quality of life in celiac and other autoimmune and autoinflammatory conditions, is to help the body limit its excessive inflammatory responses.  Removing gluten from one’s diet, using vitamin C, omega-3, corticosteroids, and hyperimmune egg, may contribute to helping the body regulate run-away inflammation.

Feel free to contact Dr. Hellen at DrHellen@DrHellenGreenblatt.info with questions or to consult with her. A message may also be left at: 1.302-265.3870 or click on: http://drhellengreenblatt.info/contact-dr-hellen/.


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Through the years, I have spoken with many individuals, usually, women, who have now been diagnosed with fibromyalgia.  Fibromyalgia is a condition in which individuals suffer from chronic pain, and have tenderness in about a dozen different spots in the body, and have “brain fog”.   They suffer from unremitting fatigue, bowel problems, difficulty in sleeping through the night, and waking up unrefreshed.  As would be expected, they are depressed and anxious as well.

 There are some physicians, even now, that think fibromyalgia “is all in the minds” of their patients.  Some studies have shown, that compared to the general population, individuals with fibromyalgia have significantly higher levels of depression and anxiety.  [Now why someone who is in pain and tired much of the time, would be depressed is beyond me.]

 I once spoke to a male physician who said that he always thought that fibromyalgia was “just” a psychological problem, having nothing to do with biology.  I asked him why he used the past tense, and he said to me, “because I got it!”. 

 Now that the pharmaceutical industry has come out with at least three FDA-approved medications for fibromyalgia, it evidently means that fibromyalgia can now be classified as a disease, and many clinicians treat it as such.  

Many patients have differing success when using these prescription medications.  The three pharmaceuticals reduced pain symptoms by only 30%.  Some of the medications made a difference in fatigue, but not in sleep patterns.  Many of these medications result in side effects ranging from insomnia (which they were trying to combat in the beginning!), nausea, and diarrhea.  Unfortunately for individuals suffering with fibromyalgia, many patients find that if the medication does work for them, too often it is for only a short-period of time, for as little as six months total.

Most clinicians state that the cause of fibromyalgia is unknown, but that “painful tissues” are not associated with inflammation. 

I respectfully suggest that inflammatory responses are major contributors to the pain and discomfort those individuals with fibromyalgia experience.  Indeed, I cannot imagine that a person can feel pain, in the absence of inflammation.

Increasingly, the literature suggests that fibromyalgia, and other neuromuscular conditions are characterized by low-grade inflammation.  Inflammatory cytokines such as tumor necrosis factor-alpha and IL-1, and other immunological factors, have been found to be at higher levels than “normals” and may be resulting in the fatigue and flu-like illness experienced by individuals with fibromyalgia.

Controlling run-away inflammation by returning to immune homeostasis, immune balance, has, in my experience, resulted in dramatic differences in the quality of life of individuals suffering with fibromyalgia.  These individuals have tried other approaches with only limited success, so why not support balanced immune responses?

Medscape Family Medicine 2012 WebMD, LLC
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