Anti-Inflammatory/Anti-Aging Strategies
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What is the Role of Inflammation?
When the body is injured or recognizes the presence of pathogens such as bacteria, viruses, molds, parasites or cancerous cells, its immune system is triggered to respond with inflammation to “burn” the threat out of the body.

Balance is Essential
Once the challenge has been met, a person in immune balance, homeostasis, will reduce the amount of inflammation that they are producing to “normal” levels. Uncontrolled, run-away  inflammation leads to autoimmune diseases (against oneself) in which its own tissues and organs are attacked.

Lupus
Systemic lupus erythematosus (SLE), lupus, is a complicated autoimmune condition affecting virtually every organ in the human body. Because of the wide-range of symptoms experienced, the disease is often difficult to diagnose. Common symptoms are extreme fatigue, swollen and/or painful joints, muscle pain, low-grade fever, thinning or loss of hair, butter-fly shaped rash across the nose and cheeks, chest pain when taking a deep breath, kidney and heart problems.

Butterfly rash

“Butterfly Rash” often associated with SLE
(
emedicine.medscape.com)

 

Females make up 80-90% of people with lupus and despite treatment, many individuals will experience flares and remissions (symptoms come and go) their entire lives.

Lupus and Inflammation
The hallmark of lupus is over-activity of the immune system and inflammation. Imbalances of inflammatory immune factors, cytokines, are significantly higher in lupus patients compared to people without lupus. These immune molecules promote inflammation and damage tissues.  High levels of these inflammatory factors are associated with the severity of disease but decrease as individuals are successfully treated.

Anti-malaria medications originally used to prevent or treat malaria has been used to treat lupus.It was not understood why these medicines were somewhat effective against SLE, but a recent study suggests that these medications inhibit inflammation.

Physical Activity
Every time a muscle contracts, it releases anti-inflammatory molecules that helps the body balance the amount of overall inflammation produced.

As would be predicted, weekly physical activity improves fatigue, depression and increases the quality of life of most individuals. Even moderate exercise, 3 days a week for 20 minutes, has been shown to make a major difference in the amount of energy and feelings of well-being experienced by lupus patients.

If  You Have Lupus
Frequent physical activity, eating in a healthful manner and daily consumption of an excellent immune balancing supplement helps the body control inflammation and achieve immune homeostasis (immune balance).

Dr.Hellen is passionate about helping people enjoy life at its fullest. She may be contacted by using this form, contacting her at: drhellen@drhellengreenblatt.info or feel free to call her at:  302.265.3870 (ET, USA).
www.niams.nih.gov/health_info/lupus/lupus_ff.asp
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An article in a recent trade publication opened with the following: “Charles couldn’t believe the intensity of the pain – and he had been shot during a tour in Iraq with the Marines. “I was lying in my sleeper and my big toe just went on fire. It was like nothing I had ever experienced. I thought I was going to pass out from the pain,” Charles explained. “My big toe was red, swollen and when I touched it, even a little, it hurt like hell”. Charles’ problem is that he suffers from gout.

 Gout is a type of arthritis that seems to run in families and results from the presence of crystals that form in the body. For example, during digestion and metabolism, the body produces uric acid which is eliminated via urine. Any uric acid that the body cannot excrete accumulates in the blood. For reasons not understood, about 30% of people with high levels of uric acid in their blood form needle-like, sharp urate crystals that end up in their joints and/or other parts of the body.

 Herbert Baraf, MD, Chevy Chase, MD, has a great analogy: “Imagine pouring packets of sugar into a glass of tea; can only hold so much in solution. And sooner or later, the sugar is going to start accumulating on the bottom of the glass.

 People with gout may go weeks or months without an attack, but when it flares up it can be excruciating and last for days. Over time, repeated attacks can eat into bone and cartilage, causing permanent damage to affected joints.

Inflammation

The presence of crystals triggers an intense inflammatory response and painful swelling the result of the body’s attempt to break down the crystals. Typically the crystals end up in joint cartilage, and for unknown reasons, especially the big toe.

gouty toe

In others, crystals settle in kidneys or the urinary tract, impairing their function or forming stones. White blood cells migrate into the joint spaces and fluids and the lubricating membranes that line the joints, the synovial membranes trying to eliminate the crystals. The immune cells attracted to the area release biological factors, cytokines and chemokines, into the surrounding area. This attracts more inflammatory cells with a result of redness, swelling and debilitating pain.

Certain immune factors are typically only in small amount in normal uninflamed joint fluids, but in individuals undergoing a gout attack (flare) the levels of the factors are significantly increased.

 Since inflammation is associated with many diseases, such as cancer, diabetes, obesity and cardiovascular health, it is not surprising to find that patients with gout are at higher risk of these diseases when compared to the general population.

 Summary:

Gout is caused by an overactive immune system using inflammation unsuccessfully to get rid of the crystals that are causing the discomfort.

Returning the immune system to balance, immune homeostasis, can result in a higher level of quality of life (QOL) for people with gout.

For years I have helped people promote  joint, digestive, energy and overall health.   Feel free to contact me DrHellen@DrHellenGreenblatt.info, use the form, or give me a call at 302.265.3870 (ET) and let us talk. Let me help you help yourself, it is  time!

www.nature.com/icb/journal/v88/n1/full/icb200999a.html
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www.hindawi.com/journals/mi/2015/680853/

 

Given all the current social, political and economic uncertainties, the holidays this year may be even more anxiety-producing and stressful than in the past. Past surveys have shown that 30-50% of people (and because of all of their responsibilities, especially women) experience heightened stresses during the holidays.

STRESS AND INFLAMMATION

Stress alters immune responses affecting our ability to fight infection and heal after injury. Inflammation is a necessary part of the immune response and is stimulated when the body is injured or exposed to pathogens or mutated cancer cells.

Short term stress stimulates the immune system by preparing it for a “flight vs. fight” response, but over a longer period of time stress results in negative imbalances of the immune system and increased inflammation. This becomes even a larger problem for people who are already in poor health or struggling with disease.

Poorly regulated  inflammation results in chronic diseases such as diabetes, arthritis, coronary heart disease, Alzheimer’s disease, dementia and even cancers, so it is important that the body carefully regulate the amount of inflammation produced.

Inflammation is a two-way street. Stress causes inflammation and inflammation causes stress.  And when the holidays or daily activities increase stress, the amount of inflammation produced by the body increases as well.

stress-and-inflammation

There are biological markers in the blood that track differences in immune responses.   The longer and greater the stress, the more likely the body is to switch from a healthy, controlled inflammatory response to one that affects its ability to fight disease and healing processes.

CONTROLLING INFLAMMATION AND STRESS 

The net effect of an inflammatory response is determined by the body balancing its inflammatory and its resulting anti-inflammatory responses.

Especially during the holidays, the four best ways to help the body balance are:

Be physically active for at least of 2.5 hours total per week.

  1. Incorporate a daily immune balancing supplement into your diet.
  2. Eat a smart, healthful diet.
  3. Keep your weight under control.

Remember:  The better you take care of your immune system, the better it will take care of you.

Graphic adapted from: Johanna Bendell, MD, with thanks.
www.psychcentral.com/holidays/
www.mayoclinic.org/healthy-lifestyle/stress-management/in-depth/stress/art-20047544
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www.ncbi.nlm.nih.gov/pubmed/27862176

 

Last week I talked with a young local Asian-American business owner who shared with me that he was “a little fatigued and stressed out”. I suggested that if he took steps to getting his immune system in balance, that since our physical and emotional well-being is dependent on homeostasis, he would feel much better.

He basically replied that, “he spends half the year in Florida, has a lot of friends that are “into” nutrition, he exercises and that he didn’t need any more information, thank you”.

Nothing like a person with an open mind, but unfortunately too many people think in this narrow way.  We all know individuals that eat nutritiously, exercise 5-7 days a week and watch their weight but they still do feel “off”.  Their fingers, elbows or knees hurt, they can’t eat everything they would like, or they have other health issues despite their “great” life style.

Nutritional Recommendations:

The evidence is strong that due to the hundreds of phytonutrients, plant nutrients, in fruits, vegetables, nuts, beans, whole grains and olive oil, that plant-based foods are important for our health. A broad variety of these phytonutrients are suggested since they appear to affect a wide-spectrum of biological functions. The consumption of plant-based foods influences the health of cells, blood pressure, risk of certain cancers, immune, dental, urinary, liver and gut health.

An additional dietary recommendation is to consume fish or fish oil 2-3 times a week for their omega-3 fatty acids. This “good” fat has multiple uses in our body, but the body cannot produced these fats by itself; we need an outside source.

Studies involving hundreds of thousands of people suggest that omega-3s reduce the risk of fatal heart disease, improve the flexibility of blood vessels, lower blood pressure and reduce immune inflammation. [Note: It is controversial whether omega-3 supplements are as beneficial as eating fish; in fact, they may cause certain health issues.]

Role of the Immune System

When the body is threatened by pathogens or cancer cells, or has been injured, the body responds with short-term inflammatory responses, acute inflammation.

Immune cells flood the area to destroy invading foreign organisms or cancer cells, or to start the healing process after trauma. If the body cannot get rid itself of the infection, or if it over-responds with excessive levels of inflammation, the immune response may become chronic, or long-term.

Chronic inflammation is abnormal and damages previously healthy tissues and organs. This sort of unlimited inflammation results in autoimmune diseases, diseases in which the body’s immune system turns on the body.  Conditions such as arthritis, diabetes, lupus, multiple sclerosis, Crohn’s disease, ulcerative colitis, celiac disease, hepatitis and asthma can result from such run-away inflammatory responses.

Knowledgeable individuals know that nutrition plays only an initial role in staying healthy. Good nutrition is the foundation upon which to build health, but it is NOT ENOUGH; it is the immune system that governs one’s health and must be optimized.

The Importance of a Balanced Immune System

Immune balance, immune homeostasis, is tightly regulated by the body. It allows the organism to respond to infection, cancer cells and injury with the right amount of inflammation.  Any imbalances, either too much stimulation, or too little, results in immune disorders and health issues.

The key to good health and healthy aging is keeping the immune system in balance.

    Scales Immune Reponses Partial

Dr.Hellen’s major passion is helping people to enjoy life at its fullest. She may be contacted by using this form, at: drhellen@drhellengreenblatt.info or feel free to call:  302.265.3870 (ET, USA).

  

nutrition.ucdavis.edu/content/infosheets/fact-pro-phytochemical.pdf
www.hsph.harvard.edu/nutritionsource/fish
www.harvardprostateknowledge.org/high-intake-of-omega-3-fats-linked-to-increased-prostate-cancer-risk
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Her dear friend’s last words to her were:

“This is horrible, I can’t breathe, I don’t want to suffer like this”.  She went on to say: “If you smoke and have COPD, let me describe to you what it’s like to live with COPD” [chronic obstructive pulmonary disease].”
  
“Pinch your nose, and put a bar straw, in your mouth. That’s one of the tiny straws they give you to stir a mixed drink. Now pinch your nose and only breathe in an out through the straw. Don’t cheat.”
 
“NOW, walk up and down the stairs about 3 or for times, Walk up and down a driveway, remember breathe only through the tiny straw. That’s what moving around and breathing is like for someone with COPD. It’s living hell! Supplemental oxygen doesn’t help much, and the medications only work during the early stages.”
 
“I have lived eleven years breathing like this. NO, I never thought this would happen to me, but it did, and it WILL probably happen to you too if you continue to smoke. SO IF YOU SMOKE STOP, do whatever you can to STOP, just STOP.

Although I have taken the liberty of modifying my friend’s statements slightly, sharing her personal comments hopefully brings a greater appreciation of the seriousness of having chronic obstructive pulmonary disease (a condition which most often the result of smoking and/or exposure to air-borne chemicals).

Internationally, chronic obstructive pulmonary disease (COPD) is the one of the leading cause of death (vying with HIV) and it is the third leading cause of death in the United States. There was a time that individuals were not aware of the dangers of smoking and as these people age, their rates of death from COPD are on the increase. Additionally, people are living longer, so more patients experience physical declines leading to disability and often, premature death.

Chronic obstructive pulmonary disease is the result of the walls of the alveoli, the balloon-like air sacks of the lungs becoming stiff and losing the ability to transfer oxygen from the lungs to the blood stream.  Also inflammatory mucus is produced in large amounts which blocks air from moving through the lung’s air passages.

Until recently, pulmonologists (lung doctors), did not recognize COPD as being caused by inflammation.  They are now convinced thatparticulates in cigarette smoke and other airborne chemicals trigger immune, inflammatory cells to “clean-up” the toxic materials. [Please see previous article on smoking.]

Over time, the inflammatory responses of the body destroy healthy lung tissue resulting in labored breathing, along with a greater susceptibility to frequent respiratory infections.

Unfortunately people with COPD treated with inhaled steroids are at greater risk of getting pneumonia and other respiratory diseases.  Additionally, individuals with HIV have greater decreases in lung function than individuals without COPD.

When a person has chronic obstructive pulmonary disease, their lungs suffer from unchecked inflammation. Control the amount of inflammation being produced, and their quality of life will change for the better.

If you want to change how you feel, contact Dr. Hellen. There are no fees for the first 30 minutes of consultation. She may be  contacted by using this form or calling:  302.265.3870 (ET, USA).

 

 http://www.ncbi.nlm.nih.gov/pubmed/23603459
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As of this writing, the Centers for Disease Control (CDC) in Atlanta is strongly recommending that pregnant woman postpone travel to many countries across the world, including the popular Caribbean islands.  The CDC is taking these steps due to the possibility that these women may become are infected with a mosquito borne virus called Zika.  The World Health Organization (WHO) Director General Dr Margaret Chan, has said that Zika had gone “from a mild threat to one of alarming proportions” and expects the virus to spread through the Americas and affect between three million and four million people.

Eighty percent of individuals who are infected with Zika do not show symptoms.  However, when symptoms do occur, they can last up to a week or so and include fever, rash, pink eye, and joint pain. Some clinicians suggest that Zika virus infection may result in the autoimmune [against oneself] condition,  Guillain-Barre syndrome (GBS).  This is rare disorder where too much inflammation damages the nerve cells, causing muscle weakness and may lead to paralysis.

The greatest concern however right now is that health agencies “strongly suspect” that when a pregnant women is bitten by a mosquito that is carring the virus, that even if she does not experience symptoms, that her offspring may develop brain malformations.

This latest outbreak adds to concerns that infectious diseases are one of the top threats challenging our world—a major topic on the agenda of last week’s World Economic Forum world leader attendees.  Until vaccines or treatments are developed, viral infections such as Zika, Ebola, SARS (severe acute respiratory syndrome), and MERS (Middle East Respiratory Syndrome) remain a threat to the world’s population.

Currently, there are no commercially available vaccines or treatments for Zika.  Until recently the cost to develop a successful vaccine was far greater than what the manufacturers would recoup in vaccine sales.  However, development of a vaccine for Zika will likely now escalate since Zika has spread so widely, infecting over 1.5 million individuals and its being linked to neurological problems, especially in newborns.

In addition to a lack of vaccines and treatments for a multitude of viral diseases, another significant health-care crisis we are facing is treatment of infection by anti-microbial-resistant pathogens. As Dr. Keiji Fukudaof the World Health Organization has stated:  “We really hope to pull the world back from the brink where antibiotics don’t work anymore”.

When bacteria are stressed, for example by a killer antibiotic, their genetic material may change, mutate, so that they can tolerate and become resistant to such compounds.  The bacteria can then replicate easily and outgrow bacterial strains that were not resistant to the antibiotic.

Fifty percent of antibiotic prescriptions written by U.S. physicians are of no benefit to the patient, and when used to fatten livestock and poultry it gives bacteria even more opportunity to acquire antibiotic tolerance.

It is our immune systems that identify, destroy, and remove invading pathogens.   When our body recognizes that it has been invaded by foreign agents, a strong inflammatory responses is triggered to meet the onslaught of the pathogens.  White blood cells accumulate in the area to combat the invaders.  These immune cells release cytokines and other immune messages  recruiting more white blood cells in an attempt to “burn out” the infection. Without a powerful inflammatory response, we cannot limit or survive infections.

In the absence of drugs or treatments that prevent and control the growth of viruses and other microorganism the immune system must be optimized to protect the body against them.

 

www.cdc.gov/mmwr/index.html
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One of the major complaints that people have is that “they are always tired”. “They just do not care anymore, they are just too tired.” [Kindly view a post that is relevant to this subject: Depression, Anhedonia and Run-Away Inflammation.]

In the past, scientists thought that there was a blood-brain barrier that “isolated” the brain from the actions of the immune system. They labeled the brain “immune privileged”; because studies suggested that a healthy brain had few, if any inflammatory cells in it. Only when there was a brain infection did scientists think that immune cells migrated into the brain.

Researchers failed to take into account that chronic inflammatory diseases are associated the brain. For example conditions such as inflammatory bowel disease, psoriasis, liver disease, and rheumatoid arthritis may result in a lack of social interest, feelings of being unwell and unremitting fatigue—all which are governed by brain function.

Inflammation is activated when the body encounters pathogens and cancerous cells. The inflammatory response is a primary means by which the body will destroy these threats. Inflammation is basically a controlled “burn”.  Firefighters will often have a “controlled burn” in a forest to get rid of dead trees and limbs.  They strive to keep the fire limited to a specific area.  Sometimes however firefighters are unable to control the fire and acres of forest are burned in error.

Similarly, once immune cells have taken care of a threat to the body, for example cancer cells, pathogens, etc., it is essential that the immune system “turn” down the inflammatory “flame”. Chronic, unnecessary inflammation leads to many autoimmune diseases that destroy their own organs, such as diabetes, Crohn’s bowel disease, multiple sclerosis, and lupus

Inflammation is all about location, location, location. If one has inflammation in the insulin-producing cells that control blood sugar, the person may get diabetes. If their intestines are inflamed they may suffer from Crohn’s.  If there is too much destruction and inflammation of nerve cells, they may suffer from multiple sclerosis.

Let us hypothesize that an individual has two trillion immune white blood cells and that half of these cells are out of control and producing too strong an inflammatory response. This inflammation is destroying previously healthy tissues and organs.  Since the body is always striving to balance inflammation, the other half a trillion of cells are working towards lowering the amount of inflammation and destruction that is going on in the body

Each of these cells is expending a trivial amount of energy trying to accomplish its task, but a tiny amount of energy multiplied by two trillion cells is a great deal of “wasted energy”. Is it any wonder why these people complain of being tired?

Individuals who have been diagnosed with autoimmune conditions have higher levels of inflammatory cytokines, immune messages, than people without disease. In heart failure patients, significant fatigue is associated with poor recovery and a higher risk of death. Patients with high levels of anti-inflammatory cytokines, molecules that decrease inflammation, recover more fully and rapidly than patients with high amounts of inflammatory cytokines. When patients are treated for their heart problems, their cytokine levels begin to resemble the cytokine ratios of healthy individuals, and their energy returns.

In mice with liver inflammation, immune cells from the liver travel to the brain and trigger other specialized immune cells called microglia releasing a biochemical that attracts more inflammatory cells into the brain, which in turn produces more inflammation.

In individuals with multiple sclerosis, a nervous system disease with a major inflammatory component, patients had less fatigue when they took anti-inflammatory medications.

The association of appropriate levels of inflammation with a healthy brain and high energy reserves is clear; the key is being in immunological balance. Once individuals balance inflammatory and anti-inflammatory cells they typically regain their energy and focus.

Aren’t you tired of being tired all the time? Don’t wait any longer. Contact Dr. Hellen to talk bout enhancing your quality of life.  There is no fee for consulting with her for the first 30 minutes.  She may be contacted by using this form or at: 302.265.3870 (ET, USA).

http://www.ncbi.nlm.nih.gov/pubmed/25905315
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Asthma: An Inflammatory Syndrome

Posted on Wednesday, October, 28th, 2015 by Dr. Hellen in Allergies | Chronic Disease | Inflammation

Asthma is an inflammatory condition which affects the lungs in negative ways. It is not a single disease, but a group of symptoms that arise from the abnormal immune responses to environmental triggers.

Asthmatics suffer from limited air flow, difficulties in breathing, heightened sensitivity to particles or toxins in the air, wheezing, coughing, and tightness of the throat and chest.

Asthma can be triggered by allergens, air-borne pollutants, upper respiratory infections (like a cold or the flu), exercise, and nonsteroidal anti-inflammatory drugs, such as acetaminophen.

The cells that line the airways, the epithelium, are the first point of contact when particles are inhaled. Until recently, scientists were unaware that these cells contribute to inflammatory responses within the lungs.

Scientists are busily trying to clarify the role of over 50 different cytokines that are involved in regulating the amount of lung inflammation that asthmatics experience. When challenged with antigens, lung cells produce great numbers of inflammatory cytokines, immune messages. These immune factors regulate the activity of genes that result in inflammation and the body’s efforts to control inflammation.  Inflammatory cytokines increase the levels of inflammation to help the body remove the antigens, while other cytokines dampen excessive immune responses, trying to bring inflammatory responses back to balance.

Structural changes in the airways result from the actions of different classes of inflammatory cells and their immune proteins and biologically active molecules. Lung cells can also release molecules that cause the muscles and blood vessels in the airways to become stiff and narrow.

The lungs become overly sensitive to environmental stimuli triggering the production of excessive levels of mucus, perhaps to help dilute and wash antigens out. These fluids can clog the airways of the lungs making it even more difficult to breathe. The hypersensitivity of the lungs results in a vicious cycle of over-active immune reactions, inflammation, and more mucus production.

10.28.15 Ashma PNG grpahic

 

As always the key to healthy immune support is balance. The body needs to produce enough inflammation to help us heal and protect us from external and internal challenges, but the inflammatory response must be well balanced and controlled.

Dr. Hellen’s major passion in life is helping people get more energy, become more productive, and enjoy life at its fullest. She may be contacted by using this form, drhellen@drhellengreenblatt.info, or at: 302.265.3870 (ET, USA).

www.gluegrant.org/inflammation-asthma.htm
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For over two decades I have noticed that individuals in immune homeostasis, immune balance, are on fewer medications or no medications than their cohorts, and the majority of them look and feel 10 years younger than other people their age. Comparing photos of how these individuals look now with photos as how they looked 10-20 years ago, it is amazing how great they look! Their youthfulness is especially apparent when I compare these photos to those of individuals that have not made the effort to control inflammation.

Too many older individuals suffer from chronic inflammatory diseases such as arthritis, diabetes, cognition deficits, Parkinson’s disease, lung, kidney, and bladder problems. Over the years there have been numerous studies associating chronic (long-term) inflammation with the development of mutating cells and cancers. However because of the time it takes to do longevity studies it is difficult to prove that limiting inflammation makes a difference in how well people age.

Just this month, a team of scientists from Keio University School of Medicine, Tokyo, Japan and the Newcastle University’s Institute for Ageing in the UK published a study of the immune status of over 1500 individuals ranging in age from 100-115 years.

The study group was divided into two: centenarians, 100-104 years of age, and semi-supercentenarians aged 105 and above. The result was that these long-lived individuals had lower levels of inflammation as compared to the general public.  

Dr. von Zglinicki, one of the investigators, said, “Centenarians and supercentenarians are different – put simply, they age slower. They can ward off diseases for much longer than the general population… it’s only recently we could mechanistically prove that inflammation actually causes accelerated ageing in mice…This study, showing for the first time that inflammation levels predict successful ageing even in the extreme old….”

Dr. Yasumichi Arai, the first author on the study said, “Our results suggest that suppression of chronic inflammation might help people to age more slowly…However, presently available potent anti-inflammatories [medications] are not suited for long-term treatment of chronic inflammation because of their strong side-effects. Safer alternatives could make a large difference for the quality of life of older people.

As I have pointed out for decades, controlling the delicate balance of inflammatory responses, i.e., achieving immune homeostasis, makes all the difference in one’s youthfulness and quality of life.

P.S.  My post of May 20, 2013 also discusses the role of inflammation in longevity.

Please contact me directly if you would like to learn simple approaches to making a difference in your health.
http://www.ncl.ac.uk/press.office/press.release/item/scientists-crack-the-secret-of-the-centenarians
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Idiopathic pulmonary fibrosis (IPF) is a disease in which the tiny air sacs or “alveoli” that make up the lungs become inflamed and are gradually replaced by scar tissue (fibrosis).  As the amount of scar tissue increases, the lungs stiffen and are unable to transfer oxygen from the lungs to the blood stream. This results in the brain and other organs becoming oxygen deprived.

As  IPF progresses, day-to-day activities such as walking short distances, climbing stairs, dressing, or even talking on the phone become a problem because the person cannot catch their breath (dyspnea).  The person feels as if they are suffocating and may require supplemental oxygen.

Advanced idiopathic pulmonary fibrosis makes people more susceptible to getting and fighting infections.

The term “ idiopathic” suggests that clinicians do not know what causes the disease.  Lung inflammation may be triggered by infection with pathogens, airborne hazards, or certain types of medical treatments.  Exposed to these types of challenges, the immune system boosts its inflammatory response to attack the pathogens and remove hazards or damaged tissues.  In a vicious cycle, the uncontrolled inflammation results in greater lung damage.

Idiopathic pulmonary fibrosis may be considered an inflammatory autoimmune disease.  Autoimmune (meaning against oneself) conditions result from the body’s overactive, defensive, inflammatory reactions to an immune challenge.  The  body’s own immune cells mistakenly attack and destroy previously healthy by-stander tissues or organs, very much like a forest fire damages healthy trees.

The body responds to injury by forming scar tissue, made mainly of the key protein collagen. Pulmonary fibrosis results in inflammation and scarring that occurs again and again.  It is an imbalance between the build-up of scars, and the breakdown of collagen that is needed for tissue repair.  In IPF, lungs with old scar tissue is found layered over old damage, while fresh scarring is seen over more recent damage.

 Lung damage in IPF patients is due to imbalances between inflammatory and anti-inflammatory cytokines, immune messengers generated in response to substances or circumstances that initiated the lung damage in the first place.  Imbalances of cytokines results in more and more fibrosis.

Individuals with IPF may find that if they are able to control the amount of inflammation produced by their immune systems, if they can stay in homeostasis, balance,  their quality of life may change for the better.

Please contact Dr. Hellen if you wish her assistance in changing your quality of life. There is no fee for her services.  She may be contacted by using this form or at: 302.265.3870 (ET, USA).

 

www.coalitionforpf.org/cytokine-functions/
www.nhlbi.nih.gov/health/health-topics/topics/ipf
www.ncbi.nlm.nih.gov/pubmed/26132817
www.immuneworks.com/autoimmune-lung-diseases/idiopathic-pulmonary-fibrosis-ipf-treatments
www.ncbi.nlm.nih.gov/pubmed/26150910
faculty.ksu.edu.sa/hadilalotair/Chests%20Library/IPF.pdf

 

 

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