Anti-Inflammatory Strategies–Achieving Homeostasis
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According to the Centers for Disease Control and Prevention (CDC), this flu season is an unusually severe outbreak with wide-spread instances of disease in 49 States with many schools being closed. The season started earlier than usual, which is never a good sign.   CDC Deputy Director Anne Schuchat has said “This year’s influenza season is proving particularly difficult”. Hospitals do not have enough beds and the prevalence of the flu has led to shortages of anti-viral medications that if prescribed in the first 48 hours may shorten symptoms by a day or so.

This season’s primary virus strain is H3N2, a deadly type of influenza A that tends to result in more severe illness and higher numbers of hospitalizations and deaths than other strains. H3N2 is especially dangerous for the frail elderly and children, although people between the ages of 50 and 64 are being hospitalized at alarming rates, second only to the elderly.  As of this post, almost 100 children have already died from the flu.

Since vaccination may lessen the severity of the illness and there are  few other options, the CDC recommends people be vaccinated with the current flu vaccine, even though it may only be 30% -40% effective. [Antibiotics are useless against viruses since they only kill bacteria.]

Although some people view the flu as “merely” annoying and inconvenient, those suffering from influenza along with COPD (chronic obstructive pulmonary disease), asthma, emphysema, diabetes and other pre-existing conditions are at a higher risk of hospitalization or death, especially if they contract a secondary bacterial infection.

The influenza virus is difficult for the body to protect itself from, because it is able to mutate rapidly and frequently. This forces the immune system to constantly change its tactics to combat the latest version of the flu.

Infection by influenza triggers an intense immune inflammatory response in the lungs in the body’s attempt to stop the virus from multiplying. The lungs’ immune cells release cytokines, small molecules that signal and recruit other cells into the lungs to increase or decrease their immune and inflammatory responses.

Lisa Brown JPEG

But such a response can be a double edged sword. Too much inflammation causes lung damage on top of the damage already caused by the virus and secondary bacterial infections such as pneumonia. Additionally, although rare, if the balance of cytokines is significantly upset, the normal level of inflammatory cytokines may become too high, resulting in a cytokine storm (or cytokine cascade) that can kill a previously healthy individual in hours.

A properly balanced immune system, one in homeostasis, is more fully prepared to defend us against invasion by foreign agents, and is ready to help us combat an infection if we get one.

Following the following steps will help keep your immune system functioning at optimum levels:

  1. Eat healthful meals with an emphasis on whole grains and plenty of colorful vegetables and fruits.
  2. Be physical active to help keep the immune system in balance; incorporate it into your daily life.
  3. Get adequate amounts of rest and avoid fatigue.
  4. Drink plenty of fluids to keep membranes moist and more resistant to invasion.
  5. Wash your hands frequently and try to keep them away from your face.
  6. Stop, or at least cut down, on your smoking—your lungs are struggling enough.
  7. Consume a superior immune support supplement to help your immune system balance.
Dr. Hellen’s passion is helping people have a better quality of life. Contact her by using this form,, or calling at: 302.265.3870 (ET, USA).

From the time of the ancient Greeks, it has been clear that the mind-gut-body connection influences one’s health; however, only during the last century have we begun to understand why this is the case.

With new tools, scientists can show that there is cross-talk between the brain, the gut and the immune system.  Immune molecules from white blood cells send messages to the brain and the gut and in turn, these organs signal back to the immune system, up-regulating (increase) or down-regulating (decrease) inflammation.

 Image stress stomach immune system brain

©2017 Dr. H. C. Greenblatt

Chronic, long-term stress, affects immune cells by changing their gene activity.  This prepares them to fight infection or trauma and increases inflammation. More immune cells are then enlisted for the fight, resulting in increased inflammation.

Inflammation is necessary for survival, but too much inflammation is linked to heart and autoimmune disease, diabetes, depression, and cancer.  This is why it is essential to maintain the right balance of signals.

Stress responses are part of a vicious cycle in which stress triggers inflammation and inflammation triggers additional stress.

In stressed mice, there are four times the numbers of immune cells than found in non-stressed mice.  Additionally in mice that are stressed 1100 genes are responsible for increasing (up-regulating) inflammation.  These genes in non-stressed mice are not activated.

Similar outcomes are seen in humans under chronic stress. For weeks and months following natural disasters such as earthquakes and hurricanes,  individuals, especially those who have suffered great personal loss, have imbalances of the immune system that affects them both physically and emotionally.

The immune system and its inflammatory responses are in exquisite balance (homeostasis).  The body expands much of its energy maintaining its balance in a steady state.  This may be the reason that people who are stressed out tend to be “tired a lot of the time”.

Let us say that your immune system consists of 30 billion cells and that 15 billion of these cells are in the attack mode with excessive inflammation (up-regulation).  Let us propose that another 15 billion cells are trying to limit the inflammatory response (down-regulation).

A total of 30 billion cells expending a “trivial” amount of energy is a great deal of wasted energy. No wonder people become exhausted when they are not in homeostasis, balance.


The key to reducing stress  is to help the immune system return to homeostasis, to its natural balance.

To better manage stress especially during the holidays:  incorporate an immune support supplement into your daily diet, be physically active 2-2.5 hours/week, spend time outdoors, eat smart, stay within healthy weight limits and remember that you are only one person—be kind to yourself; give yourself a break.

Achieving immune homeostasis will make all the difference in the quality of your emotional and physical well-being. 

Contact Dr. Hellen at:, use the form or give her a call at 302.265.3870 (ET, USA) at no charge to you.

What is the Role of Inflammation?
When the body is injured or recognizes the presence of pathogens such as bacteria, viruses, molds, parasites or cancerous cells, its immune system is triggered to respond with inflammation to “burn” the threat out of the body.

Balance is Essential
Once the challenge has been met, a person in immune balance, homeostasis, will reduce the amount of inflammation that they are producing to “normal” levels. Uncontrolled, run-away  inflammation leads to autoimmune diseases (against oneself) in which its own tissues and organs are attacked.

Systemic lupus erythematosus (SLE), lupus, is a complicated autoimmune condition affecting virtually every organ in the human body. Because of the wide-range of symptoms experienced, the disease is often difficult to diagnose. Common symptoms are extreme fatigue, swollen and/or painful joints, muscle pain, low-grade fever, thinning or loss of hair, butter-fly shaped rash across the nose and cheeks, chest pain when taking a deep breath, kidney and heart problems.

Butterfly rash

“Butterfly Rash” often associated with SLE


Females make up 80-90% of people with lupus and despite treatment, many individuals will experience flares and remissions (symptoms come and go) their entire lives.

Lupus and Inflammation
The hallmark of lupus is over-activity of the immune system and inflammation. Imbalances of inflammatory immune factors, cytokines, are significantly higher in lupus patients compared to people without lupus. These immune molecules promote inflammation and damage tissues.  High levels of these inflammatory factors are associated with the severity of disease but decrease as individuals are successfully treated.

Anti-malaria medications originally used to prevent or treat malaria has been used to treat lupus.It was not understood why these medicines were somewhat effective against SLE, but a recent study suggests that these medications inhibit inflammation.

Physical Activity
Every time a muscle contracts, it releases anti-inflammatory molecules that helps the body balance the amount of overall inflammation produced.

As would be predicted, weekly physical activity improves fatigue, depression and increases the quality of life of most individuals. Even moderate exercise, 3 days a week for 20 minutes, has been shown to make a major difference in the amount of energy and feelings of well-being experienced by lupus patients.

If  You Have Lupus
Frequent physical activity, eating in a healthful manner and daily consumption of an excellent immune balancing supplement helps the body control inflammation and achieve immune homeostasis (immune balance).

Dr.Hellen is passionate about helping people enjoy life at its fullest. She may be contacted by using this form, contacting her at: or feel free to call her at:  302.265.3870 (ET, USA).


The second leading cause of death for people under the age of 44 years is suicide. Overall, it is the the tenth leading cause of death in the United States, with veterans comprising 22.2% of this statistic.  Women are three times more likely to attempt suicide, but for every woman who takes her own life, four men will die from their attempt.

Although older adults make up only 12% of the population in the States, they account for 18% of all suicides. These fatal events in the elderly are probably under-reported by 40% with “silent suicides”, dehydration, “accidents”, medication over doses, etc. ending in death.  Additionally, double suicides involving spouses or partners occur most frequently in this population. Since the elderly are the fastest growing segment of the population, these later-life deaths are predicted to result in suicide becoming a major public health issue in the too-near future.

Inflammation and Suicide

C-reactive protein (CRP) is associated with high levels of inflammation found in people with inflammatory disorders, burn and trauma victims, in obese individuals, in people with infections or with cardiovascular disease. People with suicidal thoughts (known as suicidal ideation) or attempts, also exhibit high levels of C-reactive protein compared to people without such behaviors.

Inflammatory factors are triggered during stress and are associated with depression.


When compared to patients being treated for psychiatric disorders who are not suicidal, individuals who have contemplated or attempted suicide have increased levels of inflammatory cytokines, immune cell molecules in their blood and/or brain.

The ratio of inflammatory molecules to anti-inflammatory molecules in the body either promotes inflammation or limits it.  A healthy immune system constantly strives to maintain these factors in a delicate balance, in immune homeostasis. 

Importance of Balancing Immune Factors

Imbalances in immune regulators are harmful and lead to disease. Taking the following steps should make a major difference in helping the body and mind return to homeostasis, to its natural, healthy balance:

  • Engage in physical activity at least 30 minutes a day 5 days/week.
  • Add one or more daily servings of a superior immune support supplement to your diet.
  • Maintain a healthy weight.
  • Eat a wide variety of colorful fruits and vegetables.
  • Spend some time outdoors.

For decades I have helped people enhance their quality of life.  I can be contacted at:, use this form or give me a call at 302.265.3870 (ET USA) and let us talk. Your first 30 minutes are on me!  You’ve tried everyone and everything else, let me help you feel good again, you deserve it!

An article in a recent trade publication opened with the following: “Charles couldn’t believe the intensity of the pain – and he had been shot during a tour in Iraq with the Marines. “I was lying in my sleeper and my big toe just went on fire. It was like nothing I had ever experienced. I thought I was going to pass out from the pain,” Charles explained. “My big toe was red, swollen and when I touched it, even a little, it hurt like hell”. Charles’ problem is that he suffers from gout.

 Gout is a type of arthritis that seems to run in families and results from the presence of crystals that form in the body. For example, during digestion and metabolism, the body produces uric acid which is eliminated via urine. Any uric acid that the body cannot excrete accumulates in the blood. For reasons not understood, about 30% of people with high levels of uric acid in their blood form needle-like, sharp urate crystals that end up in their joints and/or other parts of the body.

 Herbert Baraf, MD, Chevy Chase, MD, has a great analogy: “Imagine pouring packets of sugar into a glass of tea; can only hold so much in solution. And sooner or later, the sugar is going to start accumulating on the bottom of the glass.

 People with gout may go weeks or months without an attack, but when it flares up it can be excruciating and last for days. Over time, repeated attacks can eat into bone and cartilage, causing permanent damage to affected joints.


The presence of crystals triggers an intense inflammatory response and painful swelling the result of the body’s attempt to break down the crystals. Typically the crystals end up in joint cartilage, and for unknown reasons, especially the big toe.

gouty toe

In others, crystals settle in kidneys or the urinary tract, impairing their function or forming stones. White blood cells migrate into the joint spaces and fluids and the lubricating membranes that line the joints, the synovial membranes trying to eliminate the crystals. The immune cells attracted to the area release biological factors, cytokines and chemokines, into the surrounding area. This attracts more inflammatory cells with a result of redness, swelling and debilitating pain.

Certain immune factors are typically only in small amount in normal uninflamed joint fluids, but in individuals undergoing a gout attack (flare) the levels of the factors are significantly increased.

 Since inflammation is associated with many diseases, such as cancer, diabetes, obesity and cardiovascular health, it is not surprising to find that patients with gout are at higher risk of these diseases when compared to the general population.


Gout is caused by an overactive immune system using inflammation unsuccessfully to get rid of the crystals that are causing the discomfort.

Returning the immune system to balance, immune homeostasis, can result in a higher level of quality of life (QOL) for people with gout.

For years I have helped people promote  joint, digestive, energy and overall health.   Feel free to contact me, use the form, or give me a call at 302.265.3870 (ET) and let us talk. Let me help you help yourself, it is  time!


Asthma: An Inflammatory Syndrome

Posted on Wednesday, October, 28th, 2015 by Dr. Hellen in Allergies | Chronic Disease | Inflammation

Asthma is an inflammatory condition which affects the lungs in negative ways. It is not a single disease, but a group of symptoms that arise from the abnormal immune responses to environmental triggers.

Asthmatics suffer from limited air flow, difficulties in breathing, heightened sensitivity to particles or toxins in the air, wheezing, coughing, and tightness of the throat and chest.

Asthma can be triggered by allergens, air-borne pollutants, upper respiratory infections (like a cold or the flu), exercise, and nonsteroidal anti-inflammatory drugs, such as acetaminophen.

The cells that line the airways, the epithelium, are the first point of contact when particles are inhaled. Until recently, scientists were unaware that these cells contribute to inflammatory responses within the lungs.

Scientists are busily trying to clarify the role of over 50 different cytokines that are involved in regulating the amount of lung inflammation that asthmatics experience. When challenged with antigens, lung cells produce great numbers of inflammatory cytokines, immune messages. These immune factors regulate the activity of genes that result in inflammation and the body’s efforts to control inflammation.  Inflammatory cytokines increase the levels of inflammation to help the body remove the antigens, while other cytokines dampen excessive immune responses, trying to bring inflammatory responses back to balance.

Structural changes in the airways result from the actions of different classes of inflammatory cells and their immune proteins and biologically active molecules. Lung cells can also release molecules that cause the muscles and blood vessels in the airways to become stiff and narrow.

The lungs become overly sensitive to environmental stimuli triggering the production of excessive levels of mucus, perhaps to help dilute and wash antigens out. These fluids can clog the airways of the lungs making it even more difficult to breathe. The hypersensitivity of the lungs results in a vicious cycle of over-active immune reactions, inflammation, and more mucus production.

10.28.15 Ashma PNG grpahic


As always the key to healthy immune support is balance. The body needs to produce enough inflammation to help us heal and protect us from external and internal challenges, but the inflammatory response must be well balanced and controlled.

Dr. Hellen’s major passion in life is helping people get more energy, become more productive, and enjoy life at its fullest. She may be contacted by using this form,, or at: 302.265.3870 (ET, USA).

Nearly every day people tell me that their joints are swollen and stiff, they hurt all over, and that they look and feel older than their chronological age. Most of these individuals have been diagnosed with rheumatoid arthritis.

Arthritis is a sign of a “boosted” immune system with excessive inflammation leading to joint damage. People report pain in areas such as their backs, fingers, hands, wrists, knees, and shoulders.

Rheumatoid arthritis typically affects the joints of the body. However sometimes even before joint symptoms appear, rheumatoid arthritis can involve other parts of the body including the lungs or eyes. Long-term inflammation of the lungs leads to scarring and shortness of breath, fatigue, weakness, and an on-going, chronic dry cough. If the pleura, the tissues around the lungs, become inflamed, fluid buildup may result in fever, pain when taking a breath, and difficulty in breathing.

Inflammation Is Essential for Our Survival:
Clinicians, and most lay people, focus on the harmful aspects of inflammation and try to stop the inflammatory response at all costs. Instead, all that is needed is to control the this immune response. The process of inflammation is normal, protective, and absolutely essential for our survival. Inflammation is the first step to healing after an injury or when the body is gathering its forces to stop an infection. Immune inflammation also helps the body destroy cancer cells before they grow and multiply.

When the body recognizes it has been injured or infected, the immune system releases antibodies and cytokines, smaller proteins that attract different types of immune cells into an area, to help eliminate and destroy threats to the body.

Once healing has started, the amount of inflammation that the body produces must be controlled. The genes that control inflammation have to be “turned off”, down-regulated, so that inflammatory responses are limited.

Arthritis is an Autoimmune Disorder:
Arthritis is one of many autoimmune disorders in which the body mistakenly produces autoantibodies, antibodies against its own tissues that attach to joint linings, and cartilage which acts as a shock absorber. The presence of autoantibodies may trigger immune cells to release inflammatory molecules that cause damage to the joints and other organ systems.

The Effect of Stress and Weight on Arthritis:
There are many factors that contribute to the discomfort experienced by individuals with joint issues. Two of these most recently investigated are: stress and weight.

The body increases the amount of inflammation it produces when it is exposes to constant stress and the stress of pain. It becomes part of a vicious cycle. Stress causes inflammation, and inflammation leads to more stress. There is crosstalk between the nervous, hormonal, and immune systems. Changes in one system effects the other system.

Stressed individuals suffering from rheumatoid arthritis produce much higher levels of most cytokines than people without arthritis. Immunologically they respond differently to stress.

Weight Issues:
Overweight and obese patients with rheumatoid arthritis have more pain and respond less well to medication, as compared to normal weight patients. Obesity is an inflammatory disease during which fat cells, especially those concentrated around the inner organs, pump out large numbers of inflammatory molecules. Certain inflammatory proteins are found in high number in the abdominal fat tissue of overweight and obese individuals.

Importance of Immune Balance/Immune Homeostasis:
Immune inflammation is tightly regulated by the body. It consists of a) triggering and maintaining inflammatory responses, and b) producing immune messages that decrease and/or entirely stop the inflammation. Imbalances between the two phases of inflammation results in unchecked inflammation, loss of immune homeostasis, and may result in cell and tissues damage like that experienced in rheumatoid arthritis.

The key is to incorporate lifestyle changes to help the body maintain immune balance.

 Help your body return to immune balance.  Dr. Hellen may be contacted at: 302.265.3870 ET USA, or use the contact form. Thank you.

Alcoholism is a condition in which individuals drink alcohol in excess despite the fact that their habit causes physical and mental health problems, and social, family, and/or job-related issues. Heavy alcohol consumption results in damage to many parts of the body including the brain, liver, digestive system, and  joints. Alcoholics also suffer with dementia, memory loss, depression, emotional instability, and are at increased risk of cancer of the colon, liver, and esophagus.

Immune System Effects

Prolonged, heavy alcohol consumption negatively affects immune cells and their production of cytokines, immune messages.  Alcoholics have significantly higher rates of bacterial and viral infections and when hospitalized remain hospitalized longer than those that do not abuse alcohol.   Alcohol not only kills key immune cells, but excess amounts of alcohol results in an increased risk of autoimmune responses in which the body’s immune cells mistakenly attack the body’s own healthy cells as foreign.

The body constantly strives to maintain immune inflammatory homeostasis; to balance the amount of inflammation it produces to protect the body from infection.  Imbalances of inflammatory responses, loss of immune homeostasis, result from excessive alcohol consumption. For example, white cells, immune cells, search out and destroy and remove pathogens from the lungs.  After alcohol consumption, fewer immune cells respond to the call for “help”.  Those cells that do enter the lungs are unable to kill microbes as effectively as cells from non-alcoholic animals.

The inefficient immune responses of alcoholics lead them to be more vulnerable to viral infections such as hepatitis C, influenza, and HIV and bacterial infections including tuberculosis and pneumonia. Especially after experiencing trauma, e.g., surgery, alcoholics are more likely than non-alcoholics to get pneumonia.

A mouse study is one of many that demonstrates the decreased ability of alcohol-imbibing animals to fend off infection.  Sixty percent of mice that were exposed to the flu after imbibing alcohol for two months died of the flu as compared to a 15% mortality rate of mice that had not been drinking alcohol prior to exposure.

Hormone Effects:

Cortisol, the “stress-response hormone” affects nervous, immune, circulatory, and metabolic systems of the body.  After surgery, chronic alcoholics have higher cortisol levels compared to non-alcoholic patients.  The increased inflammation that accompanies stress also leads to higher levels of depression, other addictions, and mood disorders.

Other hormones effected by alcohol consumption are those a)that may interfere with the a women’s menstrual cycle, b) the ability for men and women to enjoy sex, or c) control blood sugar.

Nervous System Complications:

Alcohol is neuro-toxic to brain cells interfering with the development, repair, and communication of nerve cells. Consumption of large amounts of alcohol leads to shrinkage of white matter in the brain, adding to depression, confusion, short-term memory loss, “fuzzy” thinking, and a greater risk of getting dementia.  Alcohol also directly affects the nervous system in other ways, causing numbness, tingling, and pain in hands and feet.

Additionally, too great a consumption of alcohol, especially over a long period of time, results in problems with absorption of nutrients, the lack of which can become so severe that certain forms of dementia are triggered.

Bone Loss

Alcohol damages osteoblasts, the cells needed to grow and maintain bone.  Destruction of osteoblasts results in decreased bone mass and susceptibility to fractures and other orthopedic problems.  When a bone fracture occurs,  immune cells rush in to start the healing process. They release immune signals, cytokines that start the inflammatory process that recruits more cells into the area. However, when there is too much inflammation, healing, and bone growth is delayed with the result that bones become brittle, thin, or misshapen.

Vitamin B12, vitamin D,  phosphate, and magnesium are needed to grow bone.  Excessive intake of alcohol is associated with low or subnormal levels of these elements, further inhibiting the growth of and repair of bones.

Skin and Injuries

The cells in the skin help defend the body from pathogens, and keep the skin healthy, youthful, and supple.  The immune cells in the skin interact with the microbes that live on the surface. Although the numbers of bacteria on healthy skin stays constant, the types of bacteria that exist change depending on environmental and immune interactions

Heavy use of alcohol significantly slows the movement of immune cells, upsetting the balance, the homeostasis of the skin. Alcoholics experience a greater number of severe skin infections than individuals that drink responsibly.

Almost half of all patients coming into an emergency room with an injury, trauma cases, have high levels of alcohol in their blood.  Drunken patients have more severe symptoms, and take longer to recover.  They also have higher rates of death as compared to non-intoxicated patients.

Because these patients have imbalances of inflammatory response, it takes them longer to heal, and wounds may become more severe, more quickly. Alcohol damage to the skin continues even after they stop drinking. Alcoholics experience longer hospital stays, especially if they are patients in an intensive care unit.

In a study of two groups of animals with burns, 50% of the animals that had not consumed alcohol survived, compared to 20% of the alcohol-consuming animals.


Although not discussed in this post, moderate intake of alcohol has a beneficial effect on inflammatory markers.  However, heavy drinking results in uncontrolled amounts of inflammation leading to a myriad of health consequences.  Controlling the amount of inflammation the body produces will make a major difference in the quality of life of an individual.

Some steps abusers of alcohol can take to help their body modulate inflammation are:

  •  Limit the number of drinks consumed*
  •  Exercise 30 minutes/day for 5 days a week (150 minute minimum/week)
  •  Have smaller food portion sizes.
  •  Consume more fruits and vegetables.

*It is recommended that women limit their alcohol intake to one drink** per day, and men to two drinks/day. [Women absorb and metabolize alcohol differently from men and are more susceptible to alcohol-related organ damage and trauma than men.]

**One drink is defined as 1.5 fluid ounces of 80-proof distilled spirits, 12 ounces of beer, or 5 ounces of wine (a pinot noir wine glass about 1/4 full).

Dr. Greenblatt  looks forward to assisting you in reaching your goals: or 1.302-265.3870 [USA, ET].




Exposure to chronic constant emotional or physical stress triggers a vicious cycle of inflammation. The stress increases the amount of inflammation that the body generates, and the additional inflammation “feeds” more stress.

Depressed individuals report that they experience high levels of tension and anxiety, fatigue, muscle discomfort, and/or gastrointestinal problems. Often they have a feeling that “something is very wrong”, but they cannot pinpoint what is bothering them.

Individuals suffering from depression often start by visiting physicians that specialize in specific organ systems of the body. For example a neurologist (specialty in the nerves), a gastroenterologist (digestive system), or a psychiatrist (medical doctor) or a psychologist, practitioners specializing in mental disorders. Unfortunately, most of these experts tend to focus on a single part of the body.

Since the human body is a single organism, and all the organ systems are integrated, it might be useful to realize that there is substantial and constant cross talk between all the organ systems of the body. Affect one part of the body and it has a ripple effect on all the other parts of the body.

As an example, when individuals are depressed, their immune cells produce large amounts of inflammatory molecules, pro-inflammatory cytokines, which circulate throughout the body. Since cytokines act in a hormone-like fashion, they affect all parts of the body and the brain.

Treatment Resistant Depression
Over seven million individuals with depression find little or no relief that prescribed antidepressant medications. A significant number of these patients have high levels of inflammatory cytokines, immune messages that result in inflammation. These inflammatory cytokines can interfere with the actions of medications.
Lifestyle Changes.

Too many individuals are convinced that only prescription medications can make a difference in their depression and anxiety. However, there are certain life style changes that may help them, with their clinician’s approval, decrease their medication.*

(*Note: The following lifestyle changes should only be incorporated after consultation with a qualified health practitioner. If you are on prescription medications, especially for depression or anxiety, DO NOT REDUCE OR STOP ANY MEDICATIONS without consulting with the prescribing health practitioner.)

Some naturally oriented steps that one can take are:

Researchers at Duke University Medical Center, Durham, NC, found that a brisk 30-minute walk or jog three times a week may be just as effective in relieving major depression as are antidepressant prescription medications. Patients were assigned to three groups: antidepressant medications only, exercise only, or a combination of both medication and exercise. The scientists found that the exercise by itself was just as effective as medication and “was equally effective in reducing depression…” as were antidepressants.

One reason exercise may be so effective in reducing the inflammatory-depression cycle is that every time a muscle contracts, it releases anti-inflammatory immune cytokines that reduce inflammation and a help to decrease anxiety, and improve mood.
The amount of time subjects are exposed to sunlight is directly related to the amount of a specific inflammatory cytokine they produce, and depressed individuals show differing levels of the cytokine when exposed to light for varying amounts of time.
Moderate exposure to sunshine and fresh air may contribute greatly to feeling less depressed. This may “simply” be because when one is exposed to sunlight, vitamin D is produced by the body.

Vitamin D is more like a “hormone” than a purely nutritional element, since it affects hundreds of genes and is a powerful immune system regulator. Although still not definitively proven, individuals living in temperate areas may find that taking vitamin D3 supplements may prove helpful.

Increase the amount of fresh and colorful fruits and vegetables, beans, fish, and chicken. Limit non-nutritious “foods”, especially fried foods, sweets, sodas (diet or regular!), white rice, and pasta. Eating in a nutritional manner may help the body regulate its daily inflammatory responses.

Fat cells, adipose cells, especially those around abdomen produce a wide range of inflammatory cytokines. As the size of the cells decrease, the amount of inflammation that the body produces decreases. Lowering inflammation helps an individual to return to their natural immune homeostasis, their natural immune balance.

Studies suggest that daily consumption of omega-3 fatty acids from fish makes a difference in depression. In a recent randomized double-blind placebo-controlled study of shift workers, supplementation with omega-3 was associated with a reduction in high sensitivity C-reactive protein (an inflammatory marker) and depression. In another study of women, the highest intake of omega-3 was associated with a 49% decrease in symptoms of depression. In the latter study, investigators suggested that omega-3 was triggering the production of anti-inflammatory compounds.

Inflammation in the body is a normal and desired process that is part of the healing cycle and it is the primary method by which the body defends itself from pathogens. The key to good health is to help the body achieve the right level of inflammation, immune homeostasis. We want the body to produce enough of an inflammatory response to defend itself from pathogens and cancerous cells, but not so much inflammation that healthy tissues are damaged.

Hyperimmune egg has been shown to help the body return to immune homeostasis, immune balance. In a university, double-blind placebo-controlled trial (the gold standard of human trials), subjects consuming hyperimmune egg reported lower levels of moodiness, anger, and hostility. [Med Sci Sports Exer 2009 5:228].

Chronic inflammation, brought about by an over-expression or lack of control of the normal protective mechanisms of the body, has been linked to range of conditions including depression.
Individuals who control inflammatory responses will have a much higher emotional and physical quality of life.

Endometriosis* is a painful, hormonal and immune system disease in which tissues similar to the mucous membranes lining the uterus (endometrium), end up in “strange” locations, places that these sorts of tissues are not typically found. The pockets of tissue react to monthly surges of estrogen and progesterone just like the uterus. These cells can be found, for example, outside the uterus, around the ovaries, fallopian tubes, the abdominal cavity, bladder, cervix, or bowels, and can become irritated and inflamed during the reproductive cycle. Eventually the condition may result in scarring and adhesions, abnormal tissue that binds organs together like a spider web.

Autoimmune Contribution?
Some scientists suggest that in endometriosis the immune cells of the woman are unable to recognize the presence of these “displaced” tissues and that the cells are not destroyed as they normally would be. Women with endometriosis, besides having greater inflammatory responses, often produce autoantibodies (antibodies against healthy tissue) and immune factors that lead to inflammatory conditions.

Endometriosis is a complex disease in which many factors, including genetic, one’s anatomy, and one’s environment all contribute to the problem. Endometriosis is associated with a disrupted inflammatory and hormonal environment in which growth factors and immune factors, such as cytokines, exist at increased levels. Women with endometriosis may exhibit excessive growth of blood vessels and nerve cells in their pelvis, which may “feed” the pain.

Endometriosis may be accompanied by heavy bleeding at anytime during the menstrual cycle, with severe pain becoming especially acute during menstruation. Pain and cramping may begin before, and extend several days into a women’s menses, and she may experience lower back and abdominal pain, bloating, diarrhea, fatigue, and malaise. Pain may be present during or after sex, and with urination, or bowel movements.

The severity of the pain experienced is an unreliable indicator of the extent of the condition. For example, women with mild endometriosis may have extensive pain, while others with advanced endometriosis may experience little or no pain.
Endometriosis can develop in girls as young as eight, or years after the onset of menstruation. While many women find that symptoms of endometriosis temporarily stop during their pregnancy, and/or completely with menopause, this is not always the case.

The main complication of endometriosis, besides excruciating pain, is infertility. Thirty to fifty percent of women suffering with endometriosis have difficulty getting pregnant.

Endometriosis is associated with an inflammatory environment of the pelvis. Different types of cytokines, immune factors, and growth factors are elevated in these individuals. For example, IL-8 is an inflammatory cytokine associated with inflammatory responses. The amount of Il-8 present in the body is strongly correlated with the severity of the disease, and contributes to the formation of adhesions.

Lean vs. Obese Women
In a study of younger women, the risk of endometriosis later in life was 40% lower in morbidly obese women as compared to lean women. The latter group had a nearly 3-fold greater risk of developing endometriosis than the obese women. This finding is contrary to expectations, since typically, obese women are at greater risk of inflammatory-mediated diseases than leaner women, and therefore would be expected to be at greater risk of developing endometriosis.

 [As an aside, heavy women that engage in regular, moderate to vigorous physical activity, lower their risk for endometrial cancer and other diseases. This result is expected, since every time muscle cells contract, they release potent anti-inflammatory molecules which balance the amount of inflammation generated by fat cells.]

Toxic Chemical Exposure
Dioxin is a toxic byproduct of industrial and consumer processes that involve chlorine or incineration of chlorine-containing substances, such as PVC, polyvinyl chloride, commonly known as “vinyl” plastics.

Exposure to dioxin and dioxin-like compounds have been shown to disrupt immune and hormonal balance and such chemicals have been implicated in the development of endometriosis and other diseases.

Non-Clinical Approaches
Physicians commonly recommend surgery and pharmaceutical approaches for endometriosis, but “alternative” approaches have been found to be helpful to others. For example acupuncture has been shown to be an effective pain treatment for some individuals. Additionally, eating a healthful diet, regular exercise, and certain amino acids may prove helpful.

Personal Note
I would be negligent if I did not mention that over a decade ago, a young researcher from West Virginia reported to me that a large number of women in a West Virginia community had been diagnosed with endometriosis. She was researching this problem, and unfortunately, she herself had endometriosis. I suggested a gradual introduction of a daily administration of 9-12 grams of polyvalent hyperimmune egg, a whole-egg protein from specially treated hens.

After a number of weeks the researcher reported back to me that her quality of life had improved dramatically. Unfortunately, I have lost contact with the investigator, so cannot report further on any changes she may have experienced.

Importance of Immune Homeostasis, Immune Balance
The key to endometriosis, as with most disease, is run-away inflammation. Therefore, achieving immune, inflammatory, homeostasis (balance) in individuals with endometriosis, may result in major differences in their quality of life.

Dr. Hellen can be contacted at: or 1.302-265.3870 [USA, ET].

*Interested parties may contact for a free information packet on endometriosis.