Anti-Inflammatory/Anti-Aging Strategies
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Today’s Wall Street Journal* reports on comments by Dr. Barbara Schildkrout, a psychiatrist at Harvard, stating that there are over “100 medical disorders [that] can masquerade as psychological conditions”.  Some of these conditions are lupus, heart disease, thyroid, dementia, Parkinson’s, diabetes, and Lyme Disease. The article goes on to quote Gary Kennedy, Director of Geriatric Psychiatry at Montefiore Medical Center in Bronx, NY : “[d]epression predicts heart disease and heart disease predictsdepression”.

 We know that much of heart disease stems from excessive inflammatory responses by the body.  The science also suggests that excessive inflammation, an immune disorder, leads to depression and vice versa.  People who are depressed have higher levels of specific immune inflammatory molecules (cytokines), than individuals that are more emotionally stable.  Cytokine production results in inflammation that affects and even damage brain cells (which adds to the emotional distress).  That is why immune homeostasis is so essential.

 Unfortunately, too many individuals are convinced that only prescription medications can make a difference in their depression and anxiety.**

 There are however, some powerful life style changes that one can make which will affect emotional health.  For example:

 EXERCISE: Researchers at Duke University Medical Center, Durham, NC, report that a brisk 30-minute walk, or jog three times a week, may be just as effective in relieving major depression as antidepressant prescription medications.  In the study, patients were assigned to
three groups: antidepressant medications only, exercise only, or a combination of both medication and exercise. The scientists found that the exercise by itself was just as effective as medication, and “was equally effective in reducing depression…”. 

One reason exercise may be effective in reducing the inflammation-depression cycle is that every time a muscle contracts, it releases anti-inflammatory immune cytokines that reduce inflammation and at the same time help to decrease anxiety, and improve mood.

SUNSHINE AND FRESH AIR: Moderate  exposure to sunshine and fresh air may contribute greatly to feeling less  depressed.  This may “simply” be due to  the fact that one is exposed to sunlight which then triggers the production of  the vitamin D by the body.

Although controversial, adding  vitamin D to one’s diet may help with moodiness since Vitamin D is more like a  “hormone” than a nutritional element.  Vitamin D affects hundreds of genes, and is a powerful immune system  regulator.

*http://online.wsj.com/article/SB10001424053111904480904576496271983911668.html

 **Note: Do not reduce or stop  ANY prescription medications without consulting with the health practitioner  that prescribed them. You might  however, after consultation with a qualified health  practitioner, wish to discuss incorporating new lifestyle  changes into your daily regimen.

As predicted by microbiologists and immunologists,  the inappropriate use of antibiotics has resulted in the appearance of certain bacteria that are resistant to different types of antibiotics.  Last year an antibiotic resistant strain of E. coli was responsible for a serious outbreak of food poisoning in Europe, especially in Germany.

Now in the US, a food processor, in collaboration with the USDA, has issued a voluntary, nationwide recall of 36 million pounds of ground turkey.According to DNA analysis, the product appears to be contaminated with a multiple-antibiotic-resistant strain of Salmonella.  At least one fatality has been reported, and 38% of the individuals with this illness have required hospitalization.

Our intestines are constantly exposed to microorganisms that are ingested during the course of a meal. Embedded in the walls of the digestive tract is the gut-associated lymphoid tissue (GALT) network.
The immune cells in these clusters mount inflammatory immune responses to protect the digestive tract, and the rest of the body, from being overwhelmed by pathogens.

Two stages make up the immune response. The first is the production of antibodies (immunoglobulins), large protein molecules, which like heat-seeking rockets, specifically bind to the  invading organisms marking them for destruction.  Other immune cells then enter the battle, mounting an inflammatory response that hopefully will be sufficient to destroy the pathogens.

Whereas in chronic (long-acting) illnesses it may be important  to down-regulate (inhibit) inflammatory responses, in acute,  short duration infections (such as food poisoning)  the body must rapidly increase, or boost, its inflammatory immune responses in response to the challenge. (This is termed the pro-inflammatory phase.)

In a healthy person, gastrointestinal distress, such as abdominal cramps, nausea, vomiting, and diarrhea, possibly associated with a headache and fever, typically resolve within a few days.  Once the threat has been met, the body initiates a strong anti-inflammatory response to return the body to its appropriate level of immune homeostasis (immune balance).

A balanced immune response is the only way your body defends itself against infection.  Even if you are infected, you are more likely to quickly resolve the infection if your immune system is functioning optimally.

Read more about food-borne infections:
http://digestive.niddk.nih.gov/ddiseases/pubs/bacteria/
http://www.cdc.gov/foodborneburden/

Aging typically does not occur overnight. Instead, it progresses gradually until you start feeling that you are indeed “aging”. You begin to realize that you cannot work or party as hard as you once did. You don not recover from workouts as quickly and you hurt the day after a hard work out. You are stiff in the morning or after a long drive. Your skin is not as tight as it once was, and winkles appear. You experience less energy, and your sexual drive suffers as well.

I am personally affronted when people share their complaints with doctors who respond that “there is nothing that can be done–you are just getting older”.
People who age poorly, are unable to control the amount of inflammation their bodies generate. Their immune cells are producing and releasing too many pro-inflammatory cytokines (1,2). These sorts of events can result in chronic inflammation, which is associated with heart and neuromuscular disease, diabetes, dementia, Alzheimer’s and autoimmune (3) conditions such as diabetes, arthritis, Crohn’s disease, Parkinson’s Disease, and multiple sclerosis. Chronic inflammatory responses have also been associated with certain types of cancers.

One would expect that if you have a “boosted” immune response, that you would be better prepared to fight infections and cancerous cells. Instead, there is a significant decline in immune responses in people that are not aging in a healthy manner. Their immune cells are not as effective as healthier individuals in recognizing and eliminating pathogens or stopping the spread of cancer cells.

Immune homeostasis, also known as immune balance, is the key to optimum health and healthy aging. The immune system controls the amount of pro-inflammatory molecules it produces by generating the right types and amount of anti-inflammatory molecules (4) to keep excessive levels of inflammation in check.

1 Pro-inflammatory -immune molecules that “up-regulate”(increase) inflammatory responses
2 Cytokines: http://ghr.nlm.nih.gov/glossary=cytokine
3 Autoimmune- http://www.niams.nih.gov/Health_Info/Autoimmune/default.asp
4 Anti-inflammatory–immune molecules that inhibit (“down-regulate”) inflammation

Selected references (others by request):
http://www.infection-research.de/fileadmin/user_upload/Perspectives2009/April2009/INFECTION-RESEARCH_Perspectives–Infectious_Diseases_and_Aging_FINAL_20_04_2009.pdf
http://www.onderzoekinformatie.nl/en/oi/nod/onderzoek/OND1295431

Hi.  If you are time-challenged, and stressed out most of the time, but the fatigue makes it even harder to cope, there are some powerful steps you can take; the most important approach you can take however, is to control immune inflammation.

Inflammation is a yin-yang of influences.  For example, inflammation is the primary way that the body protects us from illnesses initiated by pathogens or cancer cells.  You might want to view a “pro-inflammatory” response as one in which the body is trying to “burn” the infection or cancer cells out (“up-regulate” inflammation).  [A more moderate pro-inflammatory response is also used by the body for healing when we are injured or ill.]

A person who is feeling great, both emotionally and physically, is more likely to be in optimal health. In such an individual, once an immune challenge has been met, a healthy immune system will start to down-regulate (turn-down) immune inflammation (“anti-inflammatory” response).

Both phases of an inflammatory immune response are vital for survival.  The body constantly strives for an exquisite balance of both pro-inflammatory and  anti-inflammatory responses.  This is termed immune homeostasis.

Reducing the amount of excessive inflammation that your body produces will go a long way towards helping the body return to immune homeostasis.

Comments and questions welcomed:  DrHellen@DrHellenGreenblatt.info

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