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(My initial post on endometriosis can be found at: http://drhellengreenblatt.info/archives/1448)

Endometriosis is a painful, chronic (long-lasting) condition from which over 5 million girls and women suffer. This is a condition in which the lining of the uterus, called the endometrium, overgrows itself, and actually starts to spread and grow outside of the uterus. These endometrial growths or lesions can end up in the abdomen, in other organs, or as part of abdominal scars after surgery.

Follows a Menstrual Cycle/Infertility
Oddly enough, the misplaced tissue continues to follow a menstrual cycle. As these cells are under the influence of female hormones, each month the cell cluster gets larger and sheds blood and tissue and then shrinks again. The shed blood and tissues trigger inflammation resulting in pain, scar tissue, and adhesions, tissues that stick to one another and neighboring organs. Thirty-40% of women who have endometriosis are unable to have children. (This rate is 2-3 times the rate of infertility of the general population.)

Inflammatory Environment
Excruciating pain, sometimes far from the source, is a major issue for women suffering with endometriosis. Endometriosis appears to create an inflammatory environment that stimulates nerve fibers close to the endometrial lesions and other parts of the nervous system.

Genetics
Genetically, there is a seven-fold increased risk of disease in patients with a family history of the disease and the cells in the endometrial growths have damaged chromosomes.

Toxic Chemicals Implicated
The causes of endometriosis have been under study for decades, but one factor may be toxic chemicals. For example, dioxins are a group of highly toxic environmental chemicals that accumulate in the water and the food chain. They are absorbed by fat tissues and stay in the body for decades. Dioxins appear to cause developmental problems for children, interfere with hormone production, and negatively affect the immune system.

In the test tube, dioxin-like chemicals affect the production of inflammatory cytokines, immune cell factors. In one case, 79% of monkeys exposed to dioxin developed endometriosis, and the greater their exposure, the more severe their disease. Further study suggested that these monkeys had similar immune issues as did women with endometriosis.

Immune Homeostasis: A Balanced Immune System
The immune system strives to maintain a fine balance between protecting the body from the damaging consequences of toxic chemicals and “over-reacting” by causing too much of an inflammatory response.

Endometriosis is an inflammatory condition. Women with endometriosis may experience significant quality of life changes when they approach immune homeostasis.

 

On a personal note, (modified from the previous post http://drhellengreenblatt.info/archives/1448):
Over a decade ago, a young female researcher from West Virginia reported that a large number of women in her West Virginia community had been diagnosed with endometriosis. She was researching this problem, and unfortunately, she herself had endometriosis. She reported that her quality of life improved dramatically when she began to return to immune inflammatory homeostasis. [Unfortunately, she lost contact with the scientist.]


Dr. Hellen is available to work with individuals who wish to enhance their quality of life. She can be contacted at: 302.265.3870 (ET), DrHellen@DrHellenGreenblatt.info, or by using the contact form: http://drhellengreenblatt.info/contact-dr-hellen.

www.ncbi.nlm.nih.gov/pubmed/25528731
www.endometriosisassn.org/endo.html
www.cwhn.ca/en/node/39753
genomemedicine.com/content/2/10/75
www.ncbi.nlm.nih.gov/pubmed/25465987
www.ncbi.nlm.nih.gov/pubmed/25433332
www.ncbi.nlm.nih.gov/pubmed/15731321
researchpub.org/journal/bmbn/number/vol1-no2/vol1-no2-2.pdf
www.ncbi.nlm.nih.gov/pubmed/16101534

Endometriosis* is a painful, hormonal and immune system disease in which tissues similar to the mucous membranes lining the uterus (endometrium), end up in “strange” locations, places that these sorts of tissues are not typically found. The pockets of tissue react to monthly surges of estrogen and progesterone just like the uterus. These cells can be found, for example, outside the uterus, around the ovaries, fallopian tubes, the abdominal cavity, bladder, cervix, or bowels, and can become irritated and inflamed during the reproductive cycle. Eventually the condition may result in scarring and adhesions, abnormal tissue that binds organs together like a spider web.

Autoimmune Contribution?
Some scientists suggest that in endometriosis the immune cells of the woman are unable to recognize the presence of these “displaced” tissues and that the cells are not destroyed as they normally would be. Women with endometriosis, besides having greater inflammatory responses, often produce autoantibodies (antibodies against healthy tissue) and immune factors that lead to inflammatory conditions.

Endometriosis is a complex disease in which many factors, including genetic, one’s anatomy, and one’s environment all contribute to the problem. Endometriosis is associated with a disrupted inflammatory and hormonal environment in which growth factors and immune factors, such as cytokines, exist at increased levels. Women with endometriosis may exhibit excessive growth of blood vessels and nerve cells in their pelvis, which may “feed” the pain.

Symptoms
Endometriosis may be accompanied by heavy bleeding at anytime during the menstrual cycle, with severe pain becoming especially acute during menstruation. Pain and cramping may begin before, and extend several days into a women’s menses, and she may experience lower back and abdominal pain, bloating, diarrhea, fatigue, and malaise. Pain may be present during or after sex, and with urination, or bowel movements.

The severity of the pain experienced is an unreliable indicator of the extent of the condition. For example, women with mild endometriosis may have extensive pain, while others with advanced endometriosis may experience little or no pain.
Endometriosis can develop in girls as young as eight, or years after the onset of menstruation. While many women find that symptoms of endometriosis temporarily stop during their pregnancy, and/or completely with menopause, this is not always the case.

The main complication of endometriosis, besides excruciating pain, is infertility. Thirty to fifty percent of women suffering with endometriosis have difficulty getting pregnant.

Inflammation
Endometriosis is associated with an inflammatory environment of the pelvis. Different types of cytokines, immune factors, and growth factors are elevated in these individuals. For example, IL-8 is an inflammatory cytokine associated with inflammatory responses. The amount of Il-8 present in the body is strongly correlated with the severity of the disease, and contributes to the formation of adhesions.

Lean vs. Obese Women
In a study of younger women, the risk of endometriosis later in life was 40% lower in morbidly obese women as compared to lean women. The latter group had a nearly 3-fold greater risk of developing endometriosis than the obese women. This finding is contrary to expectations, since typically, obese women are at greater risk of inflammatory-mediated diseases than leaner women, and therefore would be expected to be at greater risk of developing endometriosis.

 [As an aside, heavy women that engage in regular, moderate to vigorous physical activity, lower their risk for endometrial cancer and other diseases. This result is expected, since every time muscle cells contract, they release potent anti-inflammatory molecules which balance the amount of inflammation generated by fat cells.]

Toxic Chemical Exposure
Dioxin is a toxic byproduct of industrial and consumer processes that involve chlorine or incineration of chlorine-containing substances, such as PVC, polyvinyl chloride, commonly known as “vinyl” plastics.

Exposure to dioxin and dioxin-like compounds have been shown to disrupt immune and hormonal balance and such chemicals have been implicated in the development of endometriosis and other diseases.

Non-Clinical Approaches
Physicians commonly recommend surgery and pharmaceutical approaches for endometriosis, but “alternative” approaches have been found to be helpful to others. For example acupuncture has been shown to be an effective pain treatment for some individuals. Additionally, eating a healthful diet, regular exercise, and certain amino acids may prove helpful.

Personal Note
I would be negligent if I did not mention that over a decade ago, a young researcher from West Virginia reported to me that a large number of women in a West Virginia community had been diagnosed with endometriosis. She was researching this problem, and unfortunately, she herself had endometriosis. I suggested a gradual introduction of a daily administration of 9-12 grams of polyvalent hyperimmune egg, a whole-egg protein from specially treated hens.

After a number of weeks the researcher reported back to me that her quality of life had improved dramatically. Unfortunately, I have lost contact with the investigator, so cannot report further on any changes she may have experienced.

Importance of Immune Homeostasis, Immune Balance
The key to endometriosis, as with most disease, is run-away inflammation. Therefore, achieving immune, inflammatory, homeostasis (balance) in individuals with endometriosis, may result in major differences in their quality of life.

Dr. Hellen can be contacted at: http://drhellengreenblatt.info/contact-dr-hellen/ or 1.302-265.3870 [USA, ET].

*Interested parties may contact support@endometriosisassn.org for a free information packet on endometriosis.

www.nmihi.com/e/endometriosis.htm
www.ncbi.nlm.nih.gov/pubmed/21054165
www.ncbi.nlm.nih.gov/pubmed/11949939
http://humrep.oxfordjournals.org/content/28/7/1783Share
www.endometriosisassn.org/environment.html
http://toxsci.oxfordjournals.org/content/70/2/161.full

 

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