HyperIg PL100® is whole egg protein from hens stimulated multiple times with >26 different inactivated bacteria of human-interest including Salmonella, Staphylococcus, Streptococcus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas, Proteus, Propionibacterium acnes, and Hemophilus influenzae.
In vitro, in vivo and human trials suggest that the naturally occurring immune components in hyperimmune egg (HIE) are preferentially selected by the body to help it return to, and/or achieve, inflammatory immune homeostasis.
An independent panel of experts qualified by their scientific training and experience to represent the scientific community at large, conferred self-affirmed GRAS (“generally recognized as safe”) status to hyperimmune egg. The results of the Expert Panel were submitted to the FDA, which then issued a Food Master File. This all-natural ingredient has been on the market for more than a three decades.
Over 100 U.S. and international patents and patent applications protected the technology.
Like all eggs, these eggs have as their dominant, unique immunoglobulin class IgY. Even after exposure to gastrointestinal enzymes, the Fab(2) units of orally-administered immunoglobulins appear to survive intestinal enzymatic activity and are able to neutralize microorganisms against which they were produced.
Although both table eggs and “hyperimmune” eggs contain equivalent levels of IgY and identical immunoregulatory factors, eggs from “hyperimmunized” chickens contain many-fold greater concentrations of their naturally occurring bioactive factors as compared to typical eggs (Unpublished).
Along with the production of specific immunoglobulins, stimulation of the hens results in increases in naturally occurring bioactive molecules with potent pro-, and anti-inflammatory, properties.
The immune system is a tightly regulated network that maintains a balance of immune homeostasis under normal physiological conditions. This balance is disrupted as the body defends itself against pathogens, mutating cells, and during tissue repair. The biological factors in HyperIg PL100 help the body maintain immune homeostasis by partnering to help it appropriately modulate immunological responses, especially those of an autoimmune or inflammatory nature. Thus, hyperimmune egg balances, but does not “boost” immunological responses, unless the body deems it necessary.