Anti-Inflammatory/Anti-Aging Strategies
Header image

Colorectal Cancer, Inflammation, and Immune and Digestive Homeostasis

Posted on Thursday, March, 28th, 2013 by Dr. Hellen in Cancer | Immune Homeostasis (Immune Balance) | Inflammation

Immune inflammation is the body’s way of protecting itself from infection and cancerous cells. It is also necessary for repairing damaged tissues and eliminating dangerous compounds produced internally or to which we are exposed to externally.

In the 1800’s, Dr. Rudolf Virchow, one of the 19th century’s foremost scientists, observed the presence of inflammatory immune cells in cancerous tissues and suggested that there was a connection between cancer and inflammation.

The right balance of inflammatory responses are needed to fight cancer. Too little of an immune response leaves cancer cells unrecognized and unchallenged. Too much inflammation, or going down a different pathway of immune cell stimulation, may cause the immune system to support tumor growth rather than go into an “attack” mode.

Immune and digestive homeostasis, intestinal balance, depends on the right types and numbers of microbiota (bacteria), the health of the cells that make up the intestinal lining, and the immune cells that are embedded in the intestinal walls.

Over 75-80% of the immune system is represented in the gut. The immune cells produce antibodies (immunoglobulins), cytokines, and other immune factors that help protect the digestive system from pathogens that are introduced into the gut when consuming food and drink.

Bacteria and their secretions interact with intestinal immune cells and vice versa. These bacteria play a major role in the health of the digestive tract. An inappropriate level of intestinal immune responsiveness and incorrect types and numbers of microbiota may contribute to difficulty in maintaining intestinal homeostasis, gut balance. Immune imbalances, a breakdown of any of these elements, lead to problems with the intestine such as inflammatory bowel disease or cancer.

Pre-cancerous polyps often precede the development of colorectal cancer. Several naturally occurring substances have been shown to reduce the size and number of polyps, probably by down-regulation of genes that cause inflammation.

Maintaining immune and digestive homeostasis is imperative for good health. I look forward to having you contact me about any questions you might have on limiting inflammation and returning to homeostasis. I can be contacted at: DrHellen@DrHellenGreenblatt.info or click on: http://drhellengreenblatt.info/contact-dr-hellen/. You may also reach me at: 1.302-265.3870 [USA, Eastern Time].

www.nature.com/nature/journal/v454/n7203/abs/nature07201.html
serpins.med.unc.edu/~fcc/Biology134_Folder/Pathology_213/Inflamm-Cancer.pdf
www.ncbi.nlm.nih.gov/pubmed/22893204
www.ncbi.nlm.nih.gov/pmc/articles/PMC2916138/
www.ncbi.nlm.nih.gov/pubmed/21677746

You can follow any responses to this entry through the RSS 2.0 You can leave a response, or trackback.

Leave a Reply

Your email address will not be published.

css.php