Immune Balance, Homeostasis, and Autism Spectrum Disorders (ASDs)Posted on Wednesday, August, 24th, 2011 by in Autism | Immune Homeostasis (Immune Balance)
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Autism spectrum disorders are poorly understood disorders that affect a child’s communication, thought, and social processes, and often wreck havoc on families.*
Dr. Sally Ozonoff of University of California Davis, just reported on the results of the largest study ever of siblings with and without autism. The investigators of this international, multi-center study concluded that male infants with an autistic older sibling have a 26%increased probability that they too will develop autism. If an infant has more than one older autistic sibling, then there was a 32% probability that they would develop ASD.
Modulating immune responses, for example, maintaining immune
homeostasis or balance, may be a major contributor to getting individuals with ASDs healthy.
The immune system works constantly to maintain immune homeostasis (1). Immune homeostasis is important in the gut as well and to facilitate immune health the digestive tract contains one of the body’s largest immune compartments– gut-associated lymphoid tissue (GALT) (2).
Organisms enter the body primarily through the mouth and end up in the intestinal tract. It is useful that 75-80% of the immune system is represented in the gut, to help defend thebody against infection. More immunoglobulin, antibody, is produced by the cells in the digestive tract, than anywhere else in the body. Embedded plasma cells, B-cells, produce large amounts of IgA, morethan the other antibodies, IgD, IgE, IgG, and IgM, combined (3,4).
Autism spectrum disorders (ASDs) are multi-factorial conditions which involve interactions of the gut (5,6), hormones (7), nervous (7), and immune systems (8). The relationship between some of these pathways is so suggestive that often it is called the immune-brain-gut triangle of autism. Immunological imbalances, such as impaired immune responses to certain pathogens (8) or excessive inflammation and/or responses of an autoimmune nature are often implicated as well (9-11).
Levels of various immune related molecules including proinflammatory and anti-inflammatory cytokines, nitric oxide**, specific antibodies, and antibodies against self, are different from levels found in non-autistic individuals.
Other studies show that inflammatory mediators in autism involve activation of immune brain cells (9) of the brain which are play a role in neuron function and homeostasis.ǂ
Autistic children suffer from intestinal inflammation, colitis, and have large numbers of cells indicative of infection in the gut. When their digestive problems are treated, behavioral issues are positively effected (12,13).
Autistic children and adults that have approached immune homeostasis, have necdotally experienced significant differences in theirbehavior, grades, focus, cognitive function, and social abilities.
Polyvalent hyperimmune egg has been clinically shown to help the body support and modulate immune and digestive homeostasis (14-19). The ingredient is listed in the 2011 Physicians’ Desk Reference. † The technology is based on over 30 years of research and development, and is protected by numerous patents.
Hyperimmune egg has been shown to help the body support immune and digestive function, and modulate autoimmune responses. Consider incorporating hyperimmune egg to change the quality of life of children and adults with ASDs.
1 Crimeen-Irwin B, Scalzo K, Gloster S, Mottram PL, Plebanski
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3 Brandtzaeg P, Baekkevold ES, Farstad IN, Jahnsen FL,Johansen FE, Nilsen EM, et al. Regional specialization in the mucosal immune system: what happens in the microcompartments? Immunol Today. 1999 20:141-51
4 van Egmond M, Damen CA, van Spriel AB, Vidarsson G, van Garderen E, van de Winkel JG. IgA and the IgA Fc receptor. Trends Immunol 2001 22: 205-11
5 Horvath K, Perman JA. Autism and gastrointestinal symptoms. Curr Gastroenterol Rep. 2002 4:251-8
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Pediatr. 2002 14:583-7
7. Hu VW, Nguyen A, Kim KS, Steinberg ME, Sarachana T, Scully MA, Soldin SJ, Luu T, Lee NH. Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis. PLoS One. 2009 3;4:e5775
8 Kawashti MI, Amin OR, Rowehy NG. Possible immunological disorders in autism:
concomitant autoimmunity and immune tolerance. Egypt J Immunol. 2006 13:99-104
9 Cohly HH, Panja A. Immunological findings in autism. Int Rev Neurobiol. 2005 71:317-41
10. Castellani ML, Conti CM, Kempuraj DJ, et al., Autism and immunity: revisited study. Int J Immunopathol Pharmacol. 2009 22:15-9
11. Enstrom AM, Van de Water JA, Ashwood P. Autoimmunity in autism. Curr Opin Investig Drugs 2009 10:463-73
12 Galiatsatos P, Gologan A, Lamoureux E. Autistic enterocolitis: fact or
fiction? Can J Gastroenterol. 2009 23:95-8
13 Horvath K, Perman JA. Autism and gastrointestinal symptoms. Curr Gastroenterol Rep. 2002 4:251-8
15 Trentham D et al. Hyperimmune egg in the collagen-induced arthritis model and
anti-inflammatory assays. Int Soc Rheumatol Ther (ISRT) 1998 [Abstract] p.23
16 Greenblatt HC Adalsteinssön O Kagen L. Administration to arthritis patients of a dietary supplement containing immune egg: an open-label pilot Study J Medicinal Food 1998 1:171-179
17 Jacoby HI Moore G Wnorowski G. Inhibition of diarrhea by immune egg: a castor oil mouse model J Nutraceut Function Med Foods 2001 3:47
18 US Pat # 5,772,999 Method of preventing, countering or reducing NSAID-induced gastrointestinal damage by administering milk or egg products from hyperimmunized animals
19 Kizito FB. Improvements in quality of life for HIV/AIDS patients using hperimmune egg 3rd Int AIDS Soc Conf HIV Pathogenesis and Treatment 2005 Abst #. MoPe11.2C43
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