Dr. Hellen Greenblatt

Exercise and Inflammation

The function of hundreds of genes and numerous biological pathways are affected by being physically active. Too many individuals, especially health practitioners, fail to appreciate the dominant role exercise plays in maintaining the body’s immune homeostasis, its balance. Being physically active decreases the risk of chronic inflammatory conditions such as diabetes, depression, atherosclerosis, and certain cancers.

CYTOKINE PRODUCTION

Fat cells (adipose tissue) produce pro-inflammatory cytokines, immune messages that increase the levels of inflammation in the body–inflammation which contributes to chronic disease. Upon contraction, muscles release anti-inflammatory cytokines that help the body counteract inflammation. Muscle-generated anti-inflammatory cytokines help the body balance its levels of inflammation. Consistent physical activity also helps increase immune responses to pathogens such as viruses, bacteria and mold. Even modest amount of physical activity changes the ratios of cytokines to healthful numbers.

In formerly sedentary people, 10 months of moderate walking resulted in a 16%-32% decrease in various inflammatory proteins. In another study, using resistance bands resulted in increases in the anti-inflammatory cytokine, IL-10, along with an increase in cognitive functioning. Even light activity (2–4 hours of walking-type activity/week) has been associated with better inflammatory balance.

“BRAIN-IMMUNE-GUT” AXIS

There is a “brain-immune-gut” axis. It can be a vicious cycle during which stress increases inflammation and inflammation results in more stress. Being stressed affects not only one’s emotional well-being but also hormonal, nervous and digestive status.

The microbiome, the community of organisms found on and in the body greatly influences our health. Significant crosstalk between the microbiome and the immune system results in each system affecting the other in both function and composition. Physical activity modifies the gut microbiome which in turn affects muscle, immune and brain function.
The release of anti-inflammatory immune factors not only decreases inflammation throughout the body, but it also promotes the release of brain and gut biochemicals such as dopamine, norepinephrine and serotonin, biochemicals that involved in mood and gut regulation.

Unhealthy Older Individuals

Poor aging is the result of cumulative effects of imbalances of inflammation. These individuals exhibit high levels of inflammatory cytokines which contribute to problems such as muscle weakness, neurological problems including Alzheimer’s Disease. Elderly people that remain physically active, have reduced levels of inflammation and a better quality of life with fewer chronic conditions than individuals that are not active.

Summary:

Regular physical activity suppresses inflammation by increasing the production of anti-inflammatory cytokines and inhibiting inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/26978184 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467003/ https://www.hopkinsmedicine.org/health/conditions-and-diseases/risks-of-physical-inactivity http://eir-isei.de/2019/eir-2019-084-article.pdf https://www.amjmed.com/article/S0002-9343(06)00782-0/fulltext https://www.mayoclinic.org/diseases-conditions/depression/in-depth/depression-and-exercise/art-20046495 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320801/ https://www.health.harvard.edu/mind-and-mood/exercise-is-an-all-natural-treatment-to-fight-depression
https://journals.lww.com/acsm-essr/Fulltext/2019/04000/Exercise_and_the_Gut_Microbiome__A_Review_of_the.4.aspx
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803113/ https://drhellengreenblatt.info/archives/1571

anti-inflammatory, brain function, brain immune gut axis, cytokine, exercise, immune homeostasis, immune system, inflammation, joints, muscle, physical activity

Lyme Disease and Inflammation

According to the Centers for Disease Control (CDC), Lyme disease is the fastest growing vector-borne, infectious disease in the United States with a 25 fold increase in the number of cases since surveillance of the disease began in 1982. World-wide, there are over 300 strains of these bacteria, many of which tolerate antibiotics and are able to evade immune cells.

Tick Borne Infections:
Lyme disease is associated with infected ticks and may be contacted after engaging in outdoor activities. The infected ticks bite through the skin of a person or animal, getting a blood meal and introducing the bacteria into the body. (Typically the tick has to be attached for 36 or more hours before the bacteria is passed to the host.) Symptoms may include: skin rash and painful inflammation of joints (particularly the knees) and be accompanied by flu-like symptoms such as fever, headache, fatigue and chills.

Diagnostic Testing:
Diagnostic tests are only 29-40% accurate in the first three weeks after infection. Once the infection spreads to the nervous system and joints, accuracy increases. After treatment, even when test results are “negative”, live organisms may still be found in organs. Early treatment with antibiotics and anti-inflammatory medications are helpful, but if left untreated, joints, heart, brain, muscles and brain may become involved– sometimes months or years later.

Nervous System Involvement:
About 15 percent of patients with Lyme disease develop nervous system (spine, brain, etc.) inflammation. This event is accompanied by debilitating and painful muscle and joint symptoms and major neurologic changes such as facial nerve palsy, pain radiating along the back into the legs and feet, limb pain, sensory loss and/or muscle weakness.

Inflammation results in injuries to the brain and spinal cord and may result in severe headaches, fatigue, memory loss, learning disability, depression and cognitive problems.

Inflammatory immune factors are increased in the body, recruiting more inflammatory white blood cells into the brain and the spinal cord. The healthy immune cells that protect nerve cells are damaged or destroyed by the inflammation. No longer protected, nerve cells are damaged even more.

Lingering Symptoms:
A major issue with tick-borne infections is that even after treatment; up to 25% of individuals may have persistent painful joint inflammation and other symptoms lasting months or years.

There are two factors that may account for this:
a) Small numbers of bacteria remain which the immune system has not been able to successfully eliminate.
b)Once the infection is over, traces of long-lasting bacterial proteins are found within and around the joints. These proteins trigger inflammatory responses resulting in significant joint, muscle and nerve pain. It is the body’s immune response to these residual proteins, rather than a lingering infection that results in symptoms.

Summary:
As always, the key to an active quality of life is to help the body maintain immune balance– its homeostasis. Exercise (suggested: 2.5 hours a week), maintaining a healthy weight, eating smart, going outdoors for a few minutes a day, and taking an excellent immune support product will make all the difference in one’s health.

Achieving immune homeostasis will make a difference in your life. Contact me, DrHellen@DrHellenGreenblatt.info, use the form or give me a call at 302.265.3870 and let us talk.

http://www.ilads.org/lyme/lyme-quickfacts.php

http://www.cdc.gov/lyme/signs_symptoms/index.html

https://www.statnews.com/2017/06/28/early-lyme-tests/

www.ncbi.nlm.nih.gov/pmc/articles/PMC3474947/

www.hopkinsarthritis.org/arthritis-info/lyme-disease/

ajp.amjpathol.org/article/S0002-9440(15)00123-6/fulltext

news.yale.edu/2012/06/25/even-after-lyme-disease-gone-its-remains-may-perpetuate-inflammation

www.news-medical.net/news/20171214/Study-Living-Lyme-disease-bacteria-found-months-after-antibiotic-treatment.aspx

anti-inflammatory, arthritis, autoimmune, autoinflammatory, fatigue, immune homeostasis, immune system, infection, joint pain, joints, Lyme, nervous system, Tick-borne, Ticks

Out with Inflammation = Out with Gout

An article in a recent trade publication opened with the following: “Charles couldn’t believe the intensity of the pain – and he had been shot during a tour in Iraq with the Marines. “I was lying in my sleeper and my big toe just went on fire. It was like nothing I had ever experienced. I thought I was going to pass out from the pain,” Charles explained. “My big toe was red, swollen and when I touched it, even a little, it hurt like hell”. Charles’ problem is that he suffers from gout.

Gout is a type of arthritis that seems to run in families and results from the presence of crystals that form in the body. For example, during digestion and metabolism, the body produces uric acid which is eliminated via urine. Any uric acid that the body cannot excrete accumulates in the blood. For reasons not understood, about 30% of people with high levels of uric acid in their blood form needle-like, sharp urate crystals that end up in their joints and/or other parts of the body.

Herbert Baraf, MD, Chevy Chase, MD, has a great analogy: “Imagine pouring packets of sugar into a glass of tea; can only hold so much in solution. And sooner or later, the sugar is going to start accumulating on the bottom of the glass.”

People with gout may go weeks or months without an attack, but when it flares up it can be excruciating and last for days. Over time, repeated attacks can eat into bone and cartilage, causing permanent damage to affected joints.

Inflammation

The presence of crystals triggers an intense inflammatory response and painful swelling the result of the body’s attempt to break down the crystals. Typically the crystals end up in joint cartilage, and for unknown reasons, especially the big toe.

In others, crystals settle in kidneys or the urinary tract, impairing their function or forming stones. White blood cells migrate into the joint spaces and fluids and the lubricating membranes that line the joints, the synovial membranes trying to eliminate the crystals. The immune cells attracted to the area release biological factors, cytokines and chemokines, into the surrounding area. This attracts more inflammatory cells with a result of redness, swelling and debilitating pain.

Certain immune factors are typically only in small amount in normal uninflamed joint fluids, but in individuals undergoing a gout attack (flare) the levels of the factors are significantly increased.

Since inflammation is associated with many diseases, such as cancer, diabetes, obesity and cardiovascular health, it is not surprising to find that patients with gout are at higher risk of these diseases when compared to the general population.

Summary:

Gout is caused by an overactive immune system using inflammation unsuccessfully to get rid of the crystals that are causing the discomfort.

Returning the immune system to balance, immune homeostasis, can result in a higher level of quality of life (QOL) for people with gout.

For years I have helped people promote joint, digestive, energy and overall health. Feel free to contact me DrHellen@DrHellenGreenblatt.info, use the form, or give me a call at 302.265.3870 (ET) and let us talk. Let me help you help yourself, it is time!

www.nature.com/icb/journal/v88/n1/full/icb200999a.html
fleetowner.com/driver-management-resource-center/truck-drivers-crosshairs-gout
www.nytimes.com/2013/04/27/booming/why-do-i-have-gout.html
rheumatology.oxfordjournals.org/content/44/9/1090.short
www.hopkinsarthritis.org/ask-the-expert/heredity-and-gout/
www.uptodate.com/contents/gout-beyond-the-basics
www.internationaljournalofcardiology.com/article/S0167-5273(15)30342-9/abstract?cc=y=
www.ncbi.nlm.nih.gov/pubmed/28093417
www.ncbi.nlm.nih.gov/pubmed/25332119
www.hindawi.com/journals/mi/2015/680853/

anti-inflammatory, arthritis, autoimmune, balance, cancer, chronic disease, diabetes, exercise, fat cells, gout, immune homeostasis, immune system, inflammation, inflammatory responses, joints, Obesity, pain, pro-inflammatory

A PERSONAL MESSAGE FROM DR. HELLEN GREENBLATT

| Posted by in Fatigue | Inflammation | Joints | Materials Authored by Dr. Hellen - (0 Comments)

TheseI grew up in a poor neighborhood in Brooklyn, NY. During the summers I spent most of my days sitting on the stoop, the front steps, reading piles of books that I carried home weekly from my local library, and watched people go by.

It hurt me, even at a young age, to see how hard it was for some people to get around. It broke my heart watching them as they struggled to get across the street. It seemed that everyone was in a hurry, beeping their horns, and telling them to “come on already!”. No respect for people who had dedicated their lives to working and bringing up children.

My father was known as the “Mayor” of Hopkinson Avenue, because if anyone needed his help, he was there. He was kind to people and animals. So perhaps this is why watching the older folks, I promised myself that I would make a difference in the lives of others. This goal, of being of service to others, has governed my life.

I was lucky that The College of the City of New York, CCNY, had low tuition rates. Working during school breaks for the money I needed, I became the first person in my family to graduate from College, and staying within public education systems, eventually went on to get a PhD in the sciences from SUNY Downstate Medical Center in Brooklyn, NY.

My reasoning in becoming a scientist, rather than a medical physician, was that as the former, I might only affect the life of a patient one at a time, but as a scientist, my findings might help hundreds or thousands with a single approach. And my hopes panned out, since I have been fortunate to help thousands change their quality of life.

To see comments of some folks for whom I have made a difference, please see http://drhellengreenblatt.info/notes . Some that I am reminded of:

A physician in Manhattan, NY had such significant fatigue and joint discomfort that she was forced to stop her practice and ended up in a wheelchair. Visits to other physicians, physical therapists, massage therapists, and other allopathic and complementary health practitioners did not change her quality of life. After our discussions about a protocol she might follow, she’s back in practice.

There’s Shirley F. who owns a charming restaurant on a scenic part of the Bay. Shirley does most of the preparation and cooking for her guests, but was finding it increasingly difficult to work in the kitchen. Chopping and cutting vegetables, fish, and meats was especially becoming harder and harder. Her fingers had become misshapen as well. Standing and walking around the kitchen and restaurant wasn’t becoming any easier either. After following my suggestions, Shirley found that she no longer had thoughts of giving up on her restaurant .

There’s Candy A. who had suffered from extreme gastrointestinal discomfort for years; nothing she tried made a difference. Within10 days of following my suggestion, Candy found that she was a new person.

These are just a few people who I have helped. You too deserve to feel better. It doesn’t cost you anything to talk with me. My passion is helping people improve their quality of life, naturally, and I would be delighted to help you as well. Feel free to contact me via phone 302.265.3870 (ET) or email me @ DrHellen@DrHellenGreenblatt.info.

gastrointestinal, Greenblatt, joints