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“Eczema” is worldwide the most common of chronic (long-lasting) inflammatory skin diseases.  Also called atopic dermatitis [“itis” means inflammation], it is a condition of red, inflamed, burning, itchy patches of skin. In severe cases, people experience blistering, bloody and peeling skin and raw, excruciating pain.

In the United States alone, over 30 million people have been diagnosed with dermatitis, with almost twice as many children having the condition as adults. As with most immune disorders, more females have the condition than males, and hospitalization due to flare-ups of the conditions or associated infections is associated with an 8-year reduction in lifespan.

Individuals with dermatitis are frequently embarrassed when they have an outbreak, and the itching “drives them crazy”. They have tried every approach including medications, acupuncture, herbals, creams, ointments, and different detergents.   Having dermatitis leads to at least 40% of individuals turning down an educational opportunity or job.

 

Caregivers especially report feeling frustrated, helpless, sad and guilty when dermatitis occurs in children, placing the entire family under both emotional and financial stress. There is no medical cure for eczema.

Atopic dermatitis is attributed to a combination of genetic and environmental factors. Foods such as dairy, certain nuts, soy, wheat, and allergens such as dust mites, pets, pollens have all been implicated. Additionally there are more than 80,000 chemicals registered for use today in the USA. The bottom line is that researchers do not know what causes dermatitis.

What is known, is that atopic dermatitis is a sign that the immune system, via its  inflammatory cells, is overreacting to some agent, and in the process of trying to protect itself, damages by-stander skin cells (autoinflammatory).

In moderate to severe atopic dermatitis, high numbers of inflammatory cells are found both in inflamed and unaffected skin, as well as in the blood. Long term, chronic inflammation leads to skin lesions, blisters and the other symptoms with which people with dermatitis suffer.

As Dr. Eric Simpson, a member of The American Academy of Dermatology has said, “We may not have a cure for atopic dermatitis just yet …[but] tackling inflammation is key.”

Suggestion:

There is no medical treatment for eczema however individuals that have been able to achieve immune balance, homeostasis, have found significant differences in their skin health.

Achieve balance by being physically active 4-6 days a week, consume a smart diet, maintain a healthy weight, do not smoke, or drink in excess.  Do take walks outdoors and add a proven immune balancing supplement to your daily diet and see and feel the difference.

Contact Dr. Hellen– she is there for you.  No fee is charged for the first 30 minutes of consultation.  She may be  contacted by using this form or calling:  302.265.3870 (ET-USA).
https://medlineplus.gov/eczema.html
https://www.medicalnewstoday.com/articles/14417.php
https://www.jacionline.org/article/S0091-6749(17)30205-1/pdf
http://www.jiaci.org/summary/vol28-issue6-num1694
https://www.pbs.org/newshour/science/it-could-take-centuries-for-epa-to-test-all-the-unregulated-chemicals-under-a-new-landmark-bill
https://www.ncbi.nlm.nih.gov/pubmed/30576754

It is estimated that over 33 million people in the United States are uncomfortable leaving their homes or meeting with friends because they have an overactive bladder that forces them to be close to a bathroom at all times.

People with an overactive bladder may urinate eight or more times in 24 hours and multiple times during the night. Sixty percent of elderly women and 30% of middle-aged men and women experience symptoms of an overactive bladder, urinary incontinence (leaking urine). Individuals often hesitate to share this problem with their physician.

An overactive bladder, sometimes called a “spastic bladder”, is the name given to a group of urinary symptoms. There are two types of urinary incontinence, although one can have both at once. They are urge and stress incontinence. Urge incontinence is the strong, sudden urge to urinate that cannot be ignored. When one does not get to the bathroom “in time” there may be an involuntary leakage of urine. Stress incontinence happens when people leak urine while sneezing, laughing or being physical.

When it is time to empty the bladder, a signal goes out to the brain which “tells” the muscles of the bladder to contract, pushing urine out and to empty the bladder. In people with overactive bladders, the muscles of the bladder start to contract involuntarily even when the volume of urine in the bladder is low. This involuntary contraction creates the urgent need to urinate.

Several conditions are associated with an overactive bladder. These include diabetes, certain medications, stroke, urinary tract infections, bladder stones, tumors and excessive consumption of alcohol or caffeine. In too many cases the cause is unknown; this is called an idiopathic overactive bladder condition.

Recent studies suggest that individuals with an overactive bladder have higher levels of inflammation. High levels of the inflammatory marker, C-reactive protein, and inflammatory cytokines are found in patients. When analyzing over 1800 men and 1800 women with overactive bladders, and adjusting for other conditions including smoking and alcohol consumption, the higher the C-reactive protein levels, the greater the odds of having urgent episodes and frequency. The clinicians concluded that there may be a role of inflammation in the development of this condition.

Summary.

An overactive bladder is a common condition affecting all ages and has a severe impact on quality of life. Keeping the body and bladder in homeostasis, in balance, may be an important key to reducing the sudden urge to urinate.

Contact Dr. Hellen, she is there for you.  No fee is charged for the first 30 minutes of consultation.  She may be  contacted by using this form or calling:  302.265.3870 (ET-USA).

 

www.nafc.org/overactive-bladder
www.renalandurologynews.com/aua-2010-annual-meeting/overactive-bladder-linked-to-inflammation/article/171323/
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According to the Centers for Disease Control (CDC), Lyme disease is the fastest growing vector-borne, infectious disease in the United States with a 25 fold increase in the number of cases since surveillance of the disease began in 1982. World-wide, there are over 300 strains of these bacteria, many of which tolerate antibiotics and are able to evade immune cells.

Tick Borne Infections:
Lyme disease is associated with infected ticks and may be contacted after engaging in outdoor activities. The infected ticks bite through the skin of a person or animal, getting a blood meal and introducing the bacteria into the body. (Typically the tick has to be attached for 36 or more hours before the bacteria is passed to the host.) Symptoms may include: skin rash and painful inflammation of joints (particularly the knees) and be accompanied by flu-like symptoms such as fever, headache, fatigue and chills.

Diagnostic Testing:
Diagnostic tests are only 29-40% accurate in the first three weeks after infection. Once the infection spreads to the nervous system and joints, accuracy increases. After treatment, even when test results are “negative”, live organisms may still be found in organs. Early treatment with antibiotics and anti-inflammatory medications are helpful, but if left untreated, joints, heart, brain, muscles and brain may become involved– sometimes months or years later.

Nervous System Involvement:
About 15 percent of patients with Lyme disease develop nervous system (spine, brain, etc.) inflammation. This event is accompanied by debilitating and painful muscle and joint symptoms and major neurologic changes such as facial nerve palsy, pain radiating along the back into the legs and feet, limb pain, sensory loss and/or muscle weakness.

Inflammation results in injuries to the brain and spinal cord and may result in severe headaches, fatigue, memory loss, learning disability, depression and cognitive problems.

Inflammatory immune factors are increased in the body, recruiting more inflammatory white blood cells into the brain and the spinal cord. The healthy immune cells that protect nerve cells are damaged or destroyed by the inflammation. No longer protected, nerve cells are damaged even more.

Lingering Symptoms:
A major issue with tick-borne infections is that even after treatment; up to 25% of individuals may have persistent painful joint inflammation and other symptoms lasting months or years.

There are two factors that may account for this:
a) Small numbers of bacteria remain which the immune system has not been able to successfully eliminate.
b)Once the infection is over, traces of long-lasting bacterial proteins are found within and around the joints. These proteins trigger inflammatory responses resulting in significant joint, muscle and nerve pain. It is the body’s immune response to these residual proteins, rather than a lingering infection that results in symptoms.

Summary:
As always, the key to an active quality of life is to help the body maintain immune balance– its homeostasis. Exercise (suggested: 2.5 hours a week), maintaining a healthy weight, eating smart, going outdoors for a few minutes a day, and taking an excellent immune support product will make all the difference in one’s health.

 

Achieving immune homeostasis will make a difference in your life. Contact me, DrHellen@DrHellenGreenblatt.info, use the form or give me a call at 302.265.3870 and let us talk.

http://www.ilads.org/lyme/lyme-quickfacts.php
http://www.cdc.gov/lyme/signs_symptoms/index.html
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www.news-medical.net/news/20171214/Study-Living-Lyme-disease-bacteria-found-months-after-antibiotic-treatment.aspx

What is the Role of Inflammation?
When the body is injured or recognizes the presence of pathogens such as bacteria, viruses, molds, parasites or cancerous cells, its immune system is triggered to respond with inflammation to “burn” the threat out of the body.

Balance is Essential
Once the challenge has been met, a person in immune balance, homeostasis, will reduce the amount of inflammation that they are producing to “normal” levels. Uncontrolled, run-away  inflammation leads to autoimmune diseases (against oneself) in which its own tissues and organs are attacked.

Lupus
Systemic lupus erythematosus (SLE), lupus, is a complicated autoimmune condition affecting virtually every organ in the human body. Because of the wide-range of symptoms experienced, the disease is often difficult to diagnose. Common symptoms are extreme fatigue, swollen and/or painful joints, muscle pain, low-grade fever, thinning or loss of hair, butter-fly shaped rash across the nose and cheeks, chest pain when taking a deep breath, kidney and heart problems.

Butterfly rash

“Butterfly Rash” often associated with SLE
(
emedicine.medscape.com)

 

Females make up 80-90% of people with lupus and despite treatment, many individuals will experience flares and remissions (symptoms come and go) their entire lives.

Lupus and Inflammation
The hallmark of lupus is over-activity of the immune system and inflammation. Imbalances of inflammatory immune factors, cytokines, are significantly higher in lupus patients compared to people without lupus. These immune molecules promote inflammation and damage tissues.  High levels of these inflammatory factors are associated with the severity of disease but decrease as individuals are successfully treated.

Anti-malaria medications originally used to prevent or treat malaria has been used to treat lupus.It was not understood why these medicines were somewhat effective against SLE, but a recent study suggests that these medications inhibit inflammation.

Physical Activity
Every time a muscle contracts, it releases anti-inflammatory molecules that helps the body balance the amount of overall inflammation produced.

As would be predicted, weekly physical activity improves fatigue, depression and increases the quality of life of most individuals. Even moderate exercise, 3 days a week for 20 minutes, has been shown to make a major difference in the amount of energy and feelings of well-being experienced by lupus patients.

If  You Have Lupus
Frequent physical activity, eating in a healthful manner and daily consumption of an excellent immune balancing supplement helps the body control inflammation and achieve immune homeostasis (immune balance).

Dr.Hellen is passionate about helping people enjoy life at its fullest. She may be contacted by using this form, contacting her at: drhellen@drhellengreenblatt.info or feel free to call her at:  302.265.3870 (ET, USA).
www.niams.nih.gov/health_info/lupus/lupus_ff.asp
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The second leading cause of death for people under the age of 44 years is suicide. Overall, it is the the tenth leading cause of death in the United States, with veterans comprising 22.2% of this statistic.  Women are three times more likely to attempt suicide, but for every woman who takes her own life, four men will die from their attempt.

Although older adults make up only 12% of the population in the States, they account for 18% of all suicides. These fatal events in the elderly are probably under-reported by 40% with “silent suicides”, dehydration, “accidents”, medication over doses, etc. ending in death.  Additionally, double suicides involving spouses or partners occur most frequently in this population. Since the elderly are the fastest growing segment of the population, these later-life deaths are predicted to result in suicide becoming a major public health issue in the too-near future.

Inflammation and Suicide

C-reactive protein (CRP) is associated with high levels of inflammation found in people with inflammatory disorders, burn and trauma victims, in obese individuals, in people with infections or with cardiovascular disease. People with suicidal thoughts (known as suicidal ideation) or attempts, also exhibit high levels of C-reactive protein compared to people without such behaviors.

Inflammatory factors are triggered during stress and are associated with depression.

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When compared to patients being treated for psychiatric disorders who are not suicidal, individuals who have contemplated or attempted suicide have increased levels of inflammatory cytokines, immune cell molecules in their blood and/or brain.

The ratio of inflammatory molecules to anti-inflammatory molecules in the body either promotes inflammation or limits it.  A healthy immune system constantly strives to maintain these factors in a delicate balance, in immune homeostasis. 

Importance of Balancing Immune Factors

Imbalances in immune regulators are harmful and lead to disease. Taking the following steps should make a major difference in helping the body and mind return to homeostasis, to its natural, healthy balance:

  • Engage in physical activity at least 30 minutes a day 5 days/week.
  • Add one or more daily servings of a superior immune support supplement to your diet.
  • Maintain a healthy weight.
  • Eat a wide variety of colorful fruits and vegetables.
  • Spend some time outdoors.

For decades I have helped people enhance their quality of life.  I can be contacted at: DrHellen@DrHellenGreenblatt.info, use this form or give me a call at 302.265.3870 (ET USA) and let us talk. Your first 30 minutes are on me!  You’ve tried everyone and everything else, let me help you feel good again, you deserve it!

 
afsp.org/wp-content/uploads/2016/06/2016-National-Facts-Figures.pdf

www.sciencedirect.com/science/article/pii/S1043466615300090

www.ncbi.nlm.nih.gov/pubmed/28211584

www.ncbi.nlm.nih.gov/pubmed/28135675

www.ncbi.nlm.nih.gov/pubmed/27824355

www.biologicalpsychiatryjournal.com/article/S0006-3223(14)00794-X/fulltext

Last week I talked with a young local Asian-American business owner who shared with me that he was “a little fatigued and stressed out”. I suggested that if he took steps to getting his immune system in balance, that since our physical and emotional well-being is dependent on homeostasis, he would feel much better.

He basically replied that, “he spends half the year in Florida, has a lot of friends that are “into” nutrition, he exercises and that he didn’t need any more information, thank you”.

Nothing like a person with an open mind, but unfortunately too many people think in this narrow way.  We all know individuals that eat nutritiously, exercise 5-7 days a week and watch their weight but they still do feel “off”.  Their fingers, elbows or knees hurt, they can’t eat everything they would like, or they have other health issues despite their “great” life style.

Nutritional Recommendations:

The evidence is strong that due to the hundreds of phytonutrients, plant nutrients, in fruits, vegetables, nuts, beans, whole grains and olive oil, that plant-based foods are important for our health. A broad variety of these phytonutrients are suggested since they appear to affect a wide-spectrum of biological functions. The consumption of plant-based foods influences the health of cells, blood pressure, risk of certain cancers, immune, dental, urinary, liver and gut health.

An additional dietary recommendation is to consume fish or fish oil 2-3 times a week for their omega-3 fatty acids. This “good” fat has multiple uses in our body, but the body cannot produced these fats by itself; we need an outside source.

Studies involving hundreds of thousands of people suggest that omega-3s reduce the risk of fatal heart disease, improve the flexibility of blood vessels, lower blood pressure and reduce immune inflammation. [Note: It is controversial whether omega-3 supplements are as beneficial as eating fish; in fact, they may cause certain health issues.]

Role of the Immune System

When the body is threatened by pathogens or cancer cells, or has been injured, the body responds with short-term inflammatory responses, acute inflammation.

Immune cells flood the area to destroy invading foreign organisms or cancer cells, or to start the healing process after trauma. If the body cannot get rid itself of the infection, or if it over-responds with excessive levels of inflammation, the immune response may become chronic, or long-term.

Chronic inflammation is abnormal and damages previously healthy tissues and organs. This sort of unlimited inflammation results in autoimmune diseases, diseases in which the body’s immune system turns on the body.  Conditions such as arthritis, diabetes, lupus, multiple sclerosis, Crohn’s disease, ulcerative colitis, celiac disease, hepatitis and asthma can result from such run-away inflammatory responses.

Knowledgeable individuals know that nutrition plays only an initial role in staying healthy. Good nutrition is the foundation upon which to build health, but it is NOT ENOUGH; it is the immune system that governs one’s health and must be optimized.

The Importance of a Balanced Immune System

Immune balance, immune homeostasis, is tightly regulated by the body. It allows the organism to respond to infection, cancer cells and injury with the right amount of inflammation.  Any imbalances, either too much stimulation, or too little, results in immune disorders and health issues.

The key to good health and healthy aging is keeping the immune system in balance.

    Scales Immune Reponses Partial

Dr.Hellen’s major passion is helping people to enjoy life at its fullest. She may be contacted by using this form, at: drhellen@drhellengreenblatt.info or feel free to call:  302.265.3870 (ET, USA).

  

nutrition.ucdavis.edu/content/infosheets/fact-pro-phytochemical.pdf
www.hsph.harvard.edu/nutritionsource/fish
www.harvardprostateknowledge.org/high-intake-of-omega-3-fats-linked-to-increased-prostate-cancer-risk
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www.ncbi.nlm.nih.gov/pubmed/27357102

 

One of the major complaints that people have is that “they are always tired”. “They just do not care anymore, they are just too tired.” [Kindly view a post that is relevant to this subject: Depression, Anhedonia and Run-Away Inflammation.]

In the past, scientists thought that there was a blood-brain barrier that “isolated” the brain from the actions of the immune system. They labeled the brain “immune privileged”; because studies suggested that a healthy brain had few, if any inflammatory cells in it. Only when there was a brain infection did scientists think that immune cells migrated into the brain.

Researchers failed to take into account that chronic inflammatory diseases are associated the brain. For example conditions such as inflammatory bowel disease, psoriasis, liver disease, and rheumatoid arthritis may result in a lack of social interest, feelings of being unwell and unremitting fatigue—all which are governed by brain function.

Inflammation is activated when the body encounters pathogens and cancerous cells. The inflammatory response is a primary means by which the body will destroy these threats. Inflammation is basically a controlled “burn”.  Firefighters will often have a “controlled burn” in a forest to get rid of dead trees and limbs.  They strive to keep the fire limited to a specific area.  Sometimes however firefighters are unable to control the fire and acres of forest are burned in error.

Similarly, once immune cells have taken care of a threat to the body, for example cancer cells, pathogens, etc., it is essential that the immune system “turn” down the inflammatory “flame”. Chronic, unnecessary inflammation leads to many autoimmune diseases that destroy their own organs, such as diabetes, Crohn’s bowel disease, multiple sclerosis, and lupus

Inflammation is all about location, location, location. If one has inflammation in the insulin-producing cells that control blood sugar, the person may get diabetes. If their intestines are inflamed they may suffer from Crohn’s.  If there is too much destruction and inflammation of nerve cells, they may suffer from multiple sclerosis.

Let us hypothesize that an individual has two trillion immune white blood cells and that half of these cells are out of control and producing too strong an inflammatory response. This inflammation is destroying previously healthy tissues and organs.  Since the body is always striving to balance inflammation, the other half a trillion of cells are working towards lowering the amount of inflammation and destruction that is going on in the body

Each of these cells is expending a trivial amount of energy trying to accomplish its task, but a tiny amount of energy multiplied by two trillion cells is a great deal of “wasted energy”. Is it any wonder why these people complain of being tired?

Individuals who have been diagnosed with autoimmune conditions have higher levels of inflammatory cytokines, immune messages, than people without disease. In heart failure patients, significant fatigue is associated with poor recovery and a higher risk of death. Patients with high levels of anti-inflammatory cytokines, molecules that decrease inflammation, recover more fully and rapidly than patients with high amounts of inflammatory cytokines. When patients are treated for their heart problems, their cytokine levels begin to resemble the cytokine ratios of healthy individuals, and their energy returns.

In mice with liver inflammation, immune cells from the liver travel to the brain and trigger other specialized immune cells called microglia releasing a biochemical that attracts more inflammatory cells into the brain, which in turn produces more inflammation.

In individuals with multiple sclerosis, a nervous system disease with a major inflammatory component, patients had less fatigue when they took anti-inflammatory medications.

The association of appropriate levels of inflammation with a healthy brain and high energy reserves is clear; the key is being in immunological balance. Once individuals balance inflammatory and anti-inflammatory cells they typically regain their energy and focus.

Aren’t you tired of being tired all the time? Don’t wait any longer. Contact Dr. Hellen to talk bout enhancing your quality of life.  There is no fee for consulting with her for the first 30 minutes.  She may be contacted by using this form or at: 302.265.3870 (ET, USA).

http://www.ncbi.nlm.nih.gov/pubmed/25905315
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Without the ability to produce inflammation we die.  The inflammatory response is the main weapon that the immune system uses to protect us from infection, keep cancer cells from growing out of control, and help tissues heal when they are damaged.

However, one has to have the right balance of inflammation to be healthy.  We need enough inflammation to protect us, but  too much of an inflammatory response leads to increased risk of developing diseases such as irritable bowel disease, multiple sclerosis, arthritis, lupus, and diabetes.

The mind as well as the body is negatively affected by run-away inflammation. Emotional problems such as depression, spikes of high or low moods (bipolar disorders), or schizophrenia are accompanied by uncontrolled inflammation.

Genes control the amount of inflammation that the body produces. When “inflammatory” genes are turned on, up-regulated, immune cells produce cytokines, inflammatory immune messengers, along with biological compounds such as C-reactive protein (CRP).

LONELINESS AND ANHEDONIA

Loneliness and feelings of isolation are linked to an increased risk of chronic disease and death and are associated with increased levels of inflammation.

Some depressed individuals experience anhedonia, a condition in which they   lack motivation and do not enjoy  life.  These people find no joy in food,   spending time with their family or friends, concerts, or activities that others find pleasurable.

Individuals with anhedonia experience persistent brain inflammation, among other biological events and typical treatments for depression are often not helpful.

BRAIN REGIONS COMMUNICATE WITH ONE ANOTHER

Different parts of the brain communicate with one another as they control a person’s response to pleasure and rewards such as social interactions, food and sex.  Reacting positively to these stimuli motivates one to repeat them in the future.  The ability of these regions to communicate with one another is called “connectivity”.

Individuals with low connectivity have increased inflammation and deeper feelings of anhedonia.  High CRP (an inflammatory marker) levels were also correlated with the inability to experience pleasure.

One of the medications used for individuals suffering with anhedonia is infliximab.  This medication is prescribed for patients with inflammatory conditions such as bowel disease and arthritis.  Additionally, administrating cytokines, immune messengers of inflammation, changes the reward-related regions of the brain.

DOPAMINE
Dopamine, which is produced brain cells, is strongly associated with the brain’s pleasure/reward regions. Dopamine helps us feel enjoyment and motivates us to participate in or continue to engage in activities that give us pleasure.

Decreased production of dopamine is associated with heighted inflammation and decreased connectivity between the pleasure centers of the brain. Administering inflammatory cytokines over a long period of time may lead to decreases in dopamine production.

THE LINK BETWEEN PHYSICAL ACTIVITY AND DEPRESSION

Every time muscles contract, they release anti-inflammatory molecules that help the body balance the amount of inflammation it produces.  Additionally, exercise activates the brain’s pleasure centers. The evidence shows that there is a strong link between physical activity and mental and physical health.

Regular physical activity decreases one’s risk of depression.  Researchers tracked individuals that experienced their first heart attack and had been physically active for 10 years prior to the event. Heart attack survivors who exercised for years prior to the event had a 20% lower risk of developing depression compared to individuals that had not been physically active.

Also, people who had become physically active before their first heart attack had a better protection against depression compared to those who had been active at one time,  but then became inactive.

SUMMARY

Increased inflammation has been associated with depression and other negative emotional states.  Maintaining the body’s balance of inflammatory and anti-inflammatory responses helps support healthy emotional responses.

Dr. Hellen’s major passion in life is helping people to enjoy life at its fullest. She may be contacted by using this form, at  drhellen@drhellengreenblatt.info, or at:  302.265.3870 (ET, USA).

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Idiopathic pulmonary fibrosis (IPF) is a disease in which the tiny air sacs or “alveoli” that make up the lungs become inflamed and are gradually replaced by scar tissue (fibrosis).  As the amount of scar tissue increases, the lungs stiffen and are unable to transfer oxygen from the lungs to the blood stream. This results in the brain and other organs becoming oxygen deprived.

As  IPF progresses, day-to-day activities such as walking short distances, climbing stairs, dressing, or even talking on the phone become a problem because the person cannot catch their breath (dyspnea).  The person feels as if they are suffocating and may require supplemental oxygen.

Advanced idiopathic pulmonary fibrosis makes people more susceptible to getting and fighting infections.

The term “ idiopathic” suggests that clinicians do not know what causes the disease.  Lung inflammation may be triggered by infection with pathogens, airborne hazards, or certain types of medical treatments.  Exposed to these types of challenges, the immune system boosts its inflammatory response to attack the pathogens and remove hazards or damaged tissues.  In a vicious cycle, the uncontrolled inflammation results in greater lung damage.

Idiopathic pulmonary fibrosis may be considered an inflammatory autoimmune disease.  Autoimmune (meaning against oneself) conditions result from the body’s overactive, defensive, inflammatory reactions to an immune challenge.  The  body’s own immune cells mistakenly attack and destroy previously healthy by-stander tissues or organs, very much like a forest fire damages healthy trees.

The body responds to injury by forming scar tissue, made mainly of the key protein collagen. Pulmonary fibrosis results in inflammation and scarring that occurs again and again.  It is an imbalance between the build-up of scars, and the breakdown of collagen that is needed for tissue repair.  In IPF, lungs with old scar tissue is found layered over old damage, while fresh scarring is seen over more recent damage.

 Lung damage in IPF patients is due to imbalances between inflammatory and anti-inflammatory cytokines, immune messengers generated in response to substances or circumstances that initiated the lung damage in the first place.  Imbalances of cytokines results in more and more fibrosis.

Individuals with IPF may find that if they are able to control the amount of inflammation produced by their immune systems, if they can stay in homeostasis, balance,  their quality of life may change for the better.

Please contact Dr. Hellen if you wish her assistance in changing your quality of life. There is no fee for her services.  She may be contacted by using this form or at: 302.265.3870 (ET, USA).

 

www.coalitionforpf.org/cytokine-functions/
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www.ncbi.nlm.nih.gov/pubmed/26132817
www.immuneworks.com/autoimmune-lung-diseases/idiopathic-pulmonary-fibrosis-ipf-treatments
www.ncbi.nlm.nih.gov/pubmed/26150910
faculty.ksu.edu.sa/hadilalotair/Chests%20Library/IPF.pdf

 

 

Mutating cells and invasion by pathogens triggers inflammatory responses in the body.  Inflammation consists of a series of events involving cytokines (immune messages), other immune factors, and circulating white blood cells. Uncontrolled levels of inflammation damages healthy tissues and organs.

Excessive inflammation of the eyes may result in sight-threatening condition.

Uveitis
Uveitis describes a group of eye inflammatory diseases.  Symptoms can develop gradually over a few days, or occur suddenly. Symptoms may include: photophobia (sensitivity to light), cloudy or blurred vision, increased floaters, difficulty in vision focus, headaches, “red eye” with pain ranging from a mild ache to intense pain, and loss of peripheral vision (ability to see objects at the side of one’s field of vision). Severe uveitis may lead to permanent damage to vision.

Many cases of eye tissue inflammation are “idiopathic”, i.e., without a known trigger.  Some clinicians suggest that uveitis is caused by:  a) autoimmune responses in which the body’s immune system mistakenly targets and attacks its own eye tissues, b) infections or cancer, c) trauma to the eye, or d) exposure to toxins.  Uveitis is more likely to occur in individuals that have other immune and inflammatory conditions.

Ebola and Uveitis
Two months after an American physician was treated for Ebola, and despite the fact that the virus was no longer detectable in his blood, there were high levels of Ebola virus in his eye. His eye infection was accompanied by an intense inflammatory reaction, uveitis. After much effort, the physician was successfully treated and thankfully  did not lose his sight.

In a study of 85 Ebola Virus Disease survivors in Sierra Leone, 40% reported that they had some sort of “eye problem”. (It is not known whether they also had uveitits.)

Retinitis Pigmentosa
Retinitis pigmentosa is a genetic disorder in which the light-sensitive retina, the “screen” at the back of the eye that captures images, becomes damaged .  Its photoreceptors,  rods and cones, begin to die off resulting in a  loss of vision.  This condition may end in blindness.

There are conflicting opinions as to whether inflammation plays a major role in this disease.

One study that support the contention that immune responses are involved in retinitis pigmentosa measured the levels of TNF-alpha.  TNF-alpha is a cytokine, that among other functions, helps regulate immunological responses. Depending on when and how much of the cytokine is produced , TNF-alpha may be pro-inflammatory (initiate inflammation), or anti-inflammatory (inhibit inflammation).   In animals with uveitis-like conditions, the levels of TNF-alpha in the eye are  increased between 5-10 fold over control animals.

Also,  in retinitis pigmentosa, immune white blood cells are attracted to the retina, perhaps to clean up debris from dying cells. Some investigators suggest that when these immune cells are overly stimulated, they initiate an autoimmune response, destroying other light-sensing centers in the retina.

Immune Homeostasis, Immune Balance
Immune inflammation is essential to defend the body against cancerous cells and invading microorganisms.  However, the appropriate levels of  “protective” cytokines are needed to balance the “destructive” cytokines produced in the eye so that it can maintain immune homeostasis, immune balance. Unchecked inflammation results in tissue damage and an inability of the body to mount stable and proper immune responses in the face of various challenges.

Dr. Hellen is available at 302.265.3870 for discussion on the role of inflammation and immune homeostasis in one’s health.  There is no charge to speak with her.  She may be contacted at: drhellen@drhellengreenblatt.info, or use the contact form.  Thank you.

 www.sciencedirect.com/science/article/pii/S0014483502003329
www.ncbi.nlm.nih.gov/pubmed/24174679
www.ncbi.nlm.nih.gov/pubmed/24639355
www.ncbi.nlm.nih.gov/pubmed/23608634
eyewiki.aao.org/Retinitis_Pigmentosa
www.ncbi.nlm.nih.gov/pubmed/22986109
www.ncbi.nlm.nih.gov/pubmed/21787221
www.nhs.uk/conditions/Uveitis/Pages/Introduction.aspx
www.nei.nih.gov/health/uveitis
www.nejm.org/doi/full/10.1056/NEJMoa1500306#t=article
www.nytimes.com/2015/05/08/health/weeks-after-his-recovery-ebola-lurked-in-a-doctors-eye.html?smid=tw-nytimes&_r=0

 

Parkinson’s is a disease of the nervous system that affects mobility, memory, and cognition.  Individuals may eventually experience rigid muscles, tremors of the limbs and head, loss of muscle control, monotonous speech levels, and a slow, shuffling gait.

Individuals tend to develop the disease as they age. Having a close relative with Parkinson’s disease (PD) increases the likelihood of developing Parkinson’s, with men more than 1.5 times more likely to develop the disease than females.

Although the causes of Parkinson’s disease are not clear, a recent study suggests that individuals with a specific gene are at a higher risk of getting Parkinson’s disease if they were exposed to pyrethroids, a class of chemicals found in the majority of household insecticides.  Exposure of individuals to these pesticides may result in brain tissue inflammation.

Inflammation and Autoimmune Responses

In Parkinson’s disease, the body mounts an inflammatory response against its own brain cells, its dopaminergic neurons. (An immune response against oneself is called an autoimmune response.)

These specialized brain cells produce a biochemical called dopamine with many functions including controlling bodily movements, memory, ability to think, mood, and learning.  The body’s long-lasting inflammatory response against its own nervous cells gradually destroys the dopaminergic neurons resulting in abnormal dopamine levels and brain activity, symptoms associated with Parkinson’s disease.

Microglial cells are specialized immune cells located in the brain. They are considered the “canary in the mine”.  When microglial cells sense a threat, they become “activated” and release immune factors that may, depending on the types and amounts of these molecules, be beneficial or cause damage to nerve cells.

Activated microglial cells are found in large numbers in the brains of Parkinson’s patients, along with high levels of cytokines, biochemical molecules responsible for inflammation.

The brain and spine of the nervous system are cushioned by cerebrospinal fluid. This fluid helps to provide nutrients to the nervous system and removes waste products from the brain.

Individuals with Parkinson’s disease have high levels of immune inflammatory molecules in their spinal fluid.  The more concentrated the molecules, the more likely the person is to severe fatigue, depression, and cognitive impairment.

Summary

Certain genes that control immune system responses are also strongly linked with the development of Parkinson’s disease.

Increasingly, scientific studies suggest that inflammation and autoimmune responses result in Parkinson’s disease.

Helping the body limit out-of-control inflammation, and achieving a more homeostatic, more balanced immune response, may go a long way towards changing the quality of life in individuals with Parkinson’s.

Feel free to contact Dr. Hellen. There is no fee for speaking with her. Dr. Hellen may be contacted by using this form or at: 302.265.3870 (ET).

 www.nature.com/npjparkd/
www.sciencedirect.com/science/article/pii/S1357272504003711
physrev.physiology.org/content/91/2/461
www.ncbi.nlm.nih.gov/pubmed/25757798
www.ncbi.nlm.nih.gov/pubmed/25769314
www.ncbi.nlm.nih.gov/pubmed/22166438
www.ncbi.nlm.nih.gov/pubmed/25215472
www.ncbi.nlm.nih.gov/pubmed/22814707
www.medicalnewstoday.com/articles/265378.php

(My initial post on endometriosis can be found at: http://drhellengreenblatt.info/archives/1448)

Endometriosis is a painful, chronic (long-lasting) condition from which over 5 million girls and women suffer. This is a condition in which the lining of the uterus, called the endometrium, overgrows itself, and actually starts to spread and grow outside of the uterus. These endometrial growths or lesions can end up in the abdomen, in other organs, or as part of abdominal scars after surgery.

Follows a Menstrual Cycle/Infertility
Oddly enough, the misplaced tissue continues to follow a menstrual cycle. As these cells are under the influence of female hormones, each month the cell cluster gets larger and sheds blood and tissue and then shrinks again. The shed blood and tissues trigger inflammation resulting in pain, scar tissue, and adhesions, tissues that stick to one another and neighboring organs. Thirty-40% of women who have endometriosis are unable to have children. (This rate is 2-3 times the rate of infertility of the general population.)

Inflammatory Environment
Excruciating pain, sometimes far from the source, is a major issue for women suffering with endometriosis. Endometriosis appears to create an inflammatory environment that stimulates nerve fibers close to the endometrial lesions and other parts of the nervous system.

Genetics
Genetically, there is a seven-fold increased risk of disease in patients with a family history of the disease and the cells in the endometrial growths have damaged chromosomes.

Toxic Chemicals Implicated
The causes of endometriosis have been under study for decades, but one factor may be toxic chemicals. For example, dioxins are a group of highly toxic environmental chemicals that accumulate in the water and the food chain. They are absorbed by fat tissues and stay in the body for decades. Dioxins appear to cause developmental problems for children, interfere with hormone production, and negatively affect the immune system.

In the test tube, dioxin-like chemicals affect the production of inflammatory cytokines, immune cell factors. In one case, 79% of monkeys exposed to dioxin developed endometriosis, and the greater their exposure, the more severe their disease. Further study suggested that these monkeys had similar immune issues as did women with endometriosis.

Immune Homeostasis: A Balanced Immune System
The immune system strives to maintain a fine balance between protecting the body from the damaging consequences of toxic chemicals and “over-reacting” by causing too much of an inflammatory response.

Endometriosis is an inflammatory condition. Women with endometriosis may experience significant quality of life changes when they approach immune homeostasis.

 

On a personal note, (modified from the previous post http://drhellengreenblatt.info/archives/1448):
Over a decade ago, a young female researcher from West Virginia reported that a large number of women in her West Virginia community had been diagnosed with endometriosis. She was researching this problem, and unfortunately, she herself had endometriosis. She reported that her quality of life improved dramatically when she began to return to immune inflammatory homeostasis. [Unfortunately, she lost contact with the scientist.]


Dr. Hellen is available to work with individuals who wish to enhance their quality of life. She can be contacted at: 302.265.3870 (ET), DrHellen@DrHellenGreenblatt.info, or by using the contact form: http://drhellengreenblatt.info/contact-dr-hellen.

www.ncbi.nlm.nih.gov/pubmed/25528731
www.endometriosisassn.org/endo.html
www.cwhn.ca/en/node/39753
genomemedicine.com/content/2/10/75
www.ncbi.nlm.nih.gov/pubmed/25465987
www.ncbi.nlm.nih.gov/pubmed/25433332
www.ncbi.nlm.nih.gov/pubmed/15731321
researchpub.org/journal/bmbn/number/vol1-no2/vol1-no2-2.pdf
www.ncbi.nlm.nih.gov/pubmed/16101534

Ebola virus disease (EVD), formerly known as Ebola hemorrhagic fever, is a severe, often fatal illness in humans. As of this post, the virus has spread through many African nations, and is the worst Ebola outbreak every recorded. The virus has infected over 1200 people and abuot 60% of these individuals have died from the disease.

Health practitioners have put themselves at great risk caring for those who have become infected. According to the BBC, one hundred health workers have been affected and half of them have died. At least three high-profile physicians in the forefront of care have succumbed to the virus, and three nurses who worked in the same treatment center as one of the physicians, are believed to have died from the virus.

Two Americans working to battle Ebola in Liberia, one a physician, have tested positive for the virus and are undergoing intensive treatment and workers from Doctors without Borders and the Red Cross are “overwhelmed” for the virus that has no cure.

Depending on the type of Ebola virus, up to 90% of those infected can die a rapid and difficult death. The onset of symptoms may be characterized by a sudden spiking fever, headache, joint, muscle, and stomach pain, diarrhea, vomiting, and in some cases, uncontrolled internal and external bleeding. Infected individuals die from failure of multiple organs in the body such as the nervous system, liver, and kidneys.

The disease is characterized by abnormal immune responses in which the Ebola viruses appear to evade attack of immune cells; dramatic immune imbalances occur in response to infection. There is evidence that the immune system responds with a “cytokine” storm during which certain immune cells “dump” large amounts of pro-inflammatory molecules, cytokines, into the body. Other biological compounds are released as well that contribute to the confused immune response.

Additionally, specialized cells produce insufficient amount of anti-viral cytokines, while at the same time, there is a significant increase in death of other types of immune cells. Scientists at the National Institute of Allergy and Infectious Diseases call this “a mixed anti-inflammatory response syndrome (MARS)”, and suggest that this “catastrophic uncontrolled immunological status contributes to the development of fatal hemorrhagic fever”.

Perhaps some of the symptoms that patients experience are due to autoimmune responses against individual classes of lymphocytes. This would account for the loss of certain immune cells, such as CD4 and CD8 cells. If they were available in higher numbers, they might be able to help the body fight the infection.

Many immunological factors contribute to Ebola virus fatalities. It is my contention that if  individuals were able to achieve immune homeostasis, immune balance, they would be better equipped to mount  controlled inflammatory responses which might help control the course of the disease.

 www.cdc.gov/vhf/ebola/pdf/fact-sheet.pdf
www.cdc.gov/media/releases/2014/t0728-ebola.html
www.who.int/mediacentre/factsheets/fs103/en/
www.nasw.org/users/mslong/2010/2010_09/Ebola.htm
www.vox.com/2014/7/23/5930311/ebola-virus-disease-outbreak-africa-facts-guinea?utm_medium=social&utm_source=facebook&utm_campaign=voxdotcom&utm_content=Sunday
www.ncbi.nlm.nih.gov/pubmed/20957152
www.ncbi.nlm.nih.gov/pubmed/21987781
www.ncbi.nlm.nih.gov/pmc/articles/PMC368745/

Over the last 18 months, at least 25 children have been affected in the California area by a “polio-like” illness resulting in partial paralysis of five of the children.  As of this week, two out of five of these children have tested positive for enterovirus.  According to the news media, Australia and Asia have also report similar cases.

A commonly found virus, enteroviruses typically result in only mild symptoms such as runny nose, coughing, muscle aches, and sneezing. However, there are 60 different varieties of enteroviruses, and infection with certain types of these viruses results in spontaneous abortion, stillbirth, and congenital anomalies.  Infection with other varieties of enteroviruses can lead to damage of various tissues including skin, muscles, brain, spine, nerve cells, liver, and heart.

Some enteroviruses appear to specifically target the brain and the nervous system, leading to short- or long-term paralysis affecting mobility. So for example, polio enteroviruses attack the nervous system triggering an inflammatory response to destroy the viruses.  The resulting inflammation may lead to mild paralysis, or to an individual becoming completely paralyzed within hours.

Some persistent enteroviruses survive in the body for a prolonged time with continued inflammation and damage to tissues.   So for example, polio patients that initially recover from their disease may continue to experience damage of nerve and muscle cells by inflammatory processes.  This resurgence of symptoms can result in a post-polio syndrome (PPS) years after their original exposure to the virus.

Individuals with post-polio syndrome have high levels of inflammatory cytokines, immune factors, in the spinal fluids between the thin layers of tissues that protect the spinal cord.  Other conditions resulting from enterovirus infection are often associated with the production of inflammatory molecules. Even patients with relatively mild symptoms and no nervous system complications may show increased blood levels of inflammatory immune factors.  This suggests that excessive inflammatory responses are occurring throughout the body.

A delicate balance exists between inflammatory and anti-inflammatory responses of the body.  The immune system is always on alert defending itself against infection.  However, once the process is triggered, the inflammation must be a measured, controlled response that does not destroy healthy tissue.

www.decodedscience.com/polio-like-virus-california-enterovirus-68-paralyzing-kids/43034
www.ncbi.nlm.nih.gov/pubmed/18219253
www.ninds.nih.gov/disorders/post_polio/detail_post_polio.htm
www.ncbi.nlm.nih.gov/pubmed/24367714
www.enterovirusfoundation.org/associations.shtml
www.ncbi.nlm.nih.gov/pubmed/22776106
 

Gut-associated lymphoid tissues are found in the walls of the intestine and contain billions of immune cells.  The white blood cells control the levels and types of bacteria that naturally populate the intestines.  The bacteria help to digest food that provides energy to the body,  and are part of the immune/bacterial ecosystem of the intestine.

 Interestingly, both immune cells and bacteria, protect the intestines from attack by pathogenic microorganisms, and cancer cells, and help heal the intestines when they are damaged.  Cross talk between the bacteria, and immune cells help the intestines maintain homeostasis, balance.  Each keeps the other in check.

 CELIAC DISEASE
Celiac disease is an intestinal, inflammatory, autoimmune (against oneself) disorder.  Individuals with celiac disease suffer from a wide-range of symptoms including diarrhea, fatigue, weight loss, inability to focus, skin and neurological issues, constipation, a feeling of being “bloated”, gas, anemia, headaches, osteoporosis (loss of bone density), and depression. 

 Ingesting grains, such as wheat, rye, and barley, which contain a component of protein called gluten, reportedly stimulate celiac disease.

 The presence of gluten stimulates sensitive immune cells to produce proinflammatory cytokines.  These immune messages drive inflammation, resulting in the destruction of the intestinal wall and symptoms.   Genetic, environmental, dietary, neuroendocrine, and immunological factors all contribute to disease progression.

 Currently, the primary guidance that celiacs get, is to go on a “gluten-free” diet.  Although it may be effective for some people,  such diets are restrictive, expensive, and do not work well for everyone.  In one study, every patient, 100% of those surveyed, in a cohort of 300 individuals, hoped for another option.

 OTHER APPROACHES
I often hear from people with autoimmune challenges such as celiac disease, “it’s genetic”.  Fine, so your genes are partially to blame. Meanwhile, what will you do? Continue to be uncomfortable?  So I ask those with inflammatory issues, why not consider short-term approaches until researchers discover longer-term solutions?  In three words: limit excessive inflammation.

 I like to describe inflammation as a way that the body “burns” out pathogenic microorganisms and cancer cells. The body must produce enough inflammation to protect itself from disease, and help the healing process, but not so much that healthy tissue, for example the intestinal lining, is damaged.

 Nutritional Approaches
Vitamin C and omega-3 fatty acids, from fish oil, inhibit the production of proinflammatory cytokines. (There is however,  evidence that vitamin A increases inflammatory processes.).

 Medical Approaches
Antibodies against specific inflammatory cytokines reduce intestinal injury in celiac disease, and the administration of corticosteroids, along with a gluten-free diet, was reported, in a small clinical trial, to provide benefit to celiac patients.

 Immunological Homeostasis/Balance
Hyperimmune egg, an ingredient that helps the body return to immunological balance, helps to support gastrointestinal health.  Many individuals with digestive issues report daily consumption of hyperimmune egg leads to major differences in their quality of life.

 LIMIT INFLAMMATION FOR BETTER HEALTH
The key to a higher level of quality of life in celiac and other autoimmune and autoinflammatory conditions, is to help the body limit its excessive inflammatory responses.  Removing gluten from one’s diet, using vitamin C, omega-3, corticosteroids, and hyperimmune egg, may contribute to helping the body regulate run-away inflammation.

Feel free to contact Dr. Hellen at DrHellen@DrHellenGreenblatt.info with questions or to consult with her. A message may also be left at: 1.302-265.3870 or click on: http://drhellengreenblatt.info/contact-dr-hellen/.


www.cell.com/cell-host-microbe/retrieve/pii/S1931312812000662

 www.medscape.com
 www.nature.com/nature/journal/v471/n7337/full/nature09849.html
www.nature.com/nature/journal/v471/n7337/full/nature09849.html
www.nature.com/nature/journal/v474/n7351/full/nature10208.html
www.ncbi.nlm.nih.gov/pubmed/18667914
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www.ncbi.nlm.nih.gov/pubmed/22109896
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 www.sciencedaily.com/releases/2008/11/081114185942.htm
www.sciencedaily.com/releases/2012/04/120426105654.htm

 

Recently, a professional networking site directed me to a short note by Lisa Moreno-Dickinson, President of the stopcaidnow.org. The title of her article was “When Doctors Don’t Know How to Help From Misdiagnosis to No diagnosis … What Can a Parent Do?”.

CAID refers to Childhood Auto Inflammatory Diseases. These genetic disorders usually start in infancy or childhood and are reported to be the result of gene mutations. The periodic attacks of these conditions affect many different organ systems. They are characterized by sudden inflammation and fever onset, and symptoms such as rashes, headache, abdominal, chest, muscle, and joint pains, swollen joints and scrotum.

Much of the science suggests that these conditions are not autoimmune in nature. These individuals have no any significant elevations of autoantibodies, immunoglobulins, large immune molecules that are directed against self, nor activation of specific white blood cells.

Our knowledge of the complexities of the immune system, especially its inflammatory pathways, are still in their infancy as supported by the fact that cancer, colds, infectious, and chronic diseases are rampant.

I respectfully suggest that perhaps autoinflammatory investigators have not used the appropriate assay to find autoimmune responses because a) it does not exist yet, or b) it is difficult to “test for everything”.

A recent report suggests that there is an association between autoinflammatory conditions and mitochondrial health. Mitochondria are the power stations of a cell that provides it with the energy it needs to grow, divide, and “do its job”. They play major roles in healthy aging, degenerative diseases, cancer, and ultimately, cell death. The greater its metabolic or energy requirements, the more mitochondria a cell appears to have. As an example, a muscle cell may have thousands of mitochondria and a skin cell only a few hundred.

Antibodies to mitochondrial proteins have been reported in autism spectrum disorders, which are attributed to inflammatory conditions of the nervous system. Additionally children with severe autism have higher levels of inflammatory cytokines and certain immune molecules than controls.

In Blau’s syndrome, an autoinflammatory disease, symptoms are associated with the skin, joints, and eyes. It is often mistaken for sarcoidosis, a known autoimmune disease of the skin and other organs. Crohn’s disease is an inflammatory autoimmune bowel disease in which the immune system attacks its own digestive lining.

There are two genes, NOD1 and NOD2 that help regulate the production pro-inflammatory cytokines, immune molecules that cause inflammation. Mutations of these genes are found in a number of inflammatory disorders including Blau’s syndrome, sarcoidosis, and inflammatory bowel diseases.

Investigations of the pivotal role of gene regulation of inflammatory responses are underway; however, ways to neutralize the effects of such mutations may be years away.

Parents and clinicians do not have the luxury of just waiting. We know that inappropriate inflammatory responses are occurring in many, so why not determine whether the re-introduction of immune homeostasis, immune balance would make a difference in their quality of life?

 

www.parentsociety.com/parenting/when-doctors-dont-know-what-to-do-or-how-to-help/?goback=%2Egde_151241_member_74525704

www.ncbi.nlm.nih.gov/pmc/articles/PMC2735099/

www.ncbi.nlm.nih.gov/pubmed/16466630

www.ncbi.nlm.nih.gov/pubmed/21453638

www.ncbi.nlm.nih.gov/pubmed/21083929

www.ncbi.nlm.nih.gov/pubmed/21735170

www.ncbi.nlm.nih.gov/pubmed/18368292

www.ncbi.nlm.nih.gov/pubmed/21521652

www.ncbi.nlm.nih.gov/pubmed/21433392

 

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